Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Sci Rep ; 7: 45625, 2017 03 31.
Article in English | MEDLINE | ID: mdl-28361992

ABSTRACT

Diabetes Mellitus is associated with severe cardiovascular disorders involving the renin-angiotensin system, mainly through activation of the angiotensin II type 1 receptor (AT1R). Although the type 2 receptor (AT2R) opposes the effects of AT1R, with vasodilator and anti-trophic properties, its role in diabetes is debatable. Thus we investigated AT2R-mediated dilatation in a model of type 1 diabetes induced by streptozotocin in 5-month-old male mice lacking AT2R (AT2R-/y). Glucose tolerance was reduced and markers of inflammation and oxidative stress (cyclooxygenase-2, gp91phox p22phox and p67phox) were increased in AT2R-/y mice compared to wild-type (WT) animals. Streptozotocin-induced hyperglycaemia was higher in AT2R-/y than in WT mice. Arterial gp91phox and MnSOD expression levels in addition to blood 8-isoprostane and creatinine were further increased in diabetic AT2R-/y mice compared to diabetic WT mice. AT2R-dependent dilatation in both isolated mesenteric resistance arteries and perfused kidneys was greater in diabetic mice than in non-diabetic animals. Thus, in type 1 diabetes, AT2R may reduce glycaemia and display anti-oxidant and/or anti-inflammatory properties in association with greater vasodilatation in mesenteric arteries and in the renal vasculature, a major target of diabetes. Therefore AT2R might represent a new therapeutic target in diabetes.


Subject(s)
Diabetes Mellitus, Type 1/physiopathology , Dilatation, Pathologic/physiopathology , Microvessels/physiopathology , Receptor, Angiotensin, Type 2/physiology , Animals , Diabetes Mellitus, Experimental/physiopathology , Disease Models, Animal , Inflammation/metabolism , Kidney/blood supply , Kidney/physiopathology , Male , Mesenteric Arteries/physiopathology , Mice, Transgenic , Oxidative Stress , Receptor, Angiotensin, Type 1/metabolism , Vascular Resistance
SELECTION OF CITATIONS
SEARCH DETAIL
...