Condylomata acuminata in a boy.

BACKGROUND: Human papillomaviruses, or HPV, are etiologic agents of all types of warts, including those associated with sexual transmission. Although previously rare in children, condylomata acuminata in the mouth have been reported for the past 10 to 15 years, and the possibility of sexual abuse needs to be considered. CASE DESCRIPTION: A 4-year-old boy with poor dental health presented with a wartlike mass on his upper lip, as well as two similar penile lesions. The lesions, cauliflowerlike and pedunculated in appearance, were excised, underwent biopsies and were subtyped via in situ hybridization. All of the lesions tested positive for HPV subtypes 6 and 11, which are the subtypes most often associated with anogenital warts (condylomata acuminata). Although both parents reported having genital warts, the specific mode of transmission to the child was not determined. CLINICAL IMPLICATIONS: Cases of oral condylomata acuminata in children need to be treated as possible instances of sexual abuse, and it is incumbent on the dentist to alert the appropriate community agency for follow-up.

Oral melanoacanthoma: a report of 10 cases, review of the literature, and immunohistochemical analysis for HMB-45 reactivity.

Oral melanoacanthoma (MA) is rare reactive mucosal lesion that, like cutaneous MA, demonstrates hyperplasia of spinous keratinocytes and melanocytes. Unlike MA of the skin, oral MA is unrelated to seborrheic keratosis. This series adds 10 cases to the limited number of previous reports of oral MA. The clinicopathologic features of the cases in this series are generally consistent with those previously reported in the literature; that is, although documented in various intraoral locations in patients of differing ethnicity, oral melanoacanthoma most often presents as an enlarging flat or slightly raised area of hyperpigmentation on the buccal mucosa of adult black women. The current series provides evidence of occurrence over a wider age range (5-77 years) than previously reported. Additionally, the reactivity of oral melanoacanthoma to HMB-45 was investigated. Strong HMB-45 reactivity was present in all cases, thus demonstrating its limited utility in distinguishing oral MA from malignant melanoma.