Analysis of Minerals and Toxic Elements in Commonly Consumed Herbal Medicines in Zahedan, Iran, and Associated Human Health Risk Assessment.

ABSTRACT: Herbal medicines (HMDs) are widely used in some countries. However, a consumer's health may be threatened when pollutants are present in HMDs and a high quantity of these medications is consumed. This work was conducted to evaluate the accumulation of toxic elements and the potential human health risks associated with high consumption of HMDs in Zahedan, Iran. In this study, 15 brands of popular HMDs were selected from five pharmacies. In each pharmacy, three HMD samples were randomly chosen, for a total of 225 samples, and evaluated for 11 elements. Inductively coupled plasma-optical emission spectrometry was used to analyze cadmium (Cd), lead (Pb), nickel (Ni), chromium (Cr), copper (Cu), iron (Fe), zinc (Zn), manganese (Mn), and aluminum (Al) in each sample. Total arsenic (As) and mercury (Hg) were measured by atomic absorption spectrometry. The human health risk of each element from ingestion of each HMD was estimated. The mean concentrations of these elements in different types of HMDs were highly variable and significantly different within the same type of HMD (P < 0.001). All samples contained detectable concentrations of target elements. However, the mean concentrations of each element in all HMDs were significantly lower than the legal limit published by the World Health Organization. The outcomes of this work indicated that for both children and adults, the target hazard quotient (THQ) for each metal and the hazard index (HI) for all metals in all types of HMDs were significantly lower than the acceptable limit (THQ and HI = 1). The incremental lifetime cancer risk (ILCR) for each carcinogenic metal and the total carcinogenic risk (TCR) for all carcinogenic metals also were lower than the acceptable limit (ILCR and TCR = 10-4).

Extraction and determination of heavy metals in soil and vegetables irrigated with treated municipal wastewater using new mode of dispersive liquid-liquid microextraction based on the solidified deep eutectic solvent followed by GFAAS.

BACKGROUND: In this research, a new extraction method based on dispersive liquid-liquid microextraction and the solidification of deep eutectic solvent has been developed for the determination of heavy metals in soil and vegetables prior to their analysis by graphite furnace atomic absorption spectrometry (GFAAS). In this method, a green solvent consisting of 1-decyl-3-methylimidazolium chloride and 1-undecanol was used as an extraction solvent, yielding the advantages of material stability, low density and a suitable freezing point near room temperature. RESULTS: Under optimal conditions, enrichment factors are in the range of 114-172. The calibration graphs are linear in the range of 0.02-200 µg kg-1 and limits of detection are in the range of 0.01-0.03 µg kg-1 . Repeatability and reproducibility of the method based on seven replicate measurements of 0.80 µg kg-1 of Hg and 0.20 µg kg-1 of Pb and Cd in analyzed samples were in the range of 2.3-4.1% and 3.7-6.6%, respectively. CONCLUSION: A new deep eutectic solvent consists of two parts: 1-decyl-3-methylimidazolium chloride and 1-undecanol in a molar ratio of 1:2. The accuracy of the proposed procedure was also assessed by determining the concentration of the studied metal ions in a polluted farmland soil standard reference material. © 2018 Society of Chemical Industry.