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1.
J Stomatol Oral Maxillofac Surg ; : 101935, 2024 May 31.
Article in English | MEDLINE | ID: mdl-38825236

ABSTRACT

To answer the increased demand for augmentation rhinoplasty, particularly in Asian demographics, a shift from autogenous materials to synthetic implants like silicone and expanded polytetrafluoroethylene has been witnessed. These materials present an increased risk of complications like infection, extrusion, capsular contracture, and dissatisfaction. This study focuses on a case of revision rhinoplasty in a 48-year-old patient with a previous silicone implant and propose an innovative approach in managing the implant capsule. The use of the existing capsule as a mechanical and biological support structure for the diced cartilage graft in dorsal reconstruction showcases a promising method to mitigate risks and improve outcomes in revision surgeries. The capsule around the silicone is biologically active and provides a good environment for the cartilage graft to survive and improve the healing process. This approach tends to minimize the dissection to avoid potential revision complications like skin necrosis, fibrotic tissue, and infections.

2.
Future Oncol ; 15(3): 331-343, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30523696

ABSTRACT

Targeted anticancer therapies are an important weapon in the fight against cancer. Targeted therapies interfere with specific molecules necessary for tumor growth and cancer progression. They are divided mainly to either monoclonal antibodies or small molecules inhibitors. Their primary objective is to target directly and precisely the cancer cells leading to a minimal side-effects profile. The dermatologic adverse reactions of these targeted therapies is different from those seen with classical cytotoxic chemotherapy. Rashes, xerosis, hand-foot-skin reaction and mucositis are the most frequent side effects. In this paper, we aim to present a comprehensive review of the dermatologic side effects of targeted therapies including, specific side effects related to recently, approved targeted therapies.


Subject(s)
Antibodies, Monoclonal/adverse effects , Neoplasms/drug therapy , Skin Diseases/physiopathology , Small Molecule Libraries/adverse effects , Antibodies, Monoclonal/therapeutic use , Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Exanthema/chemically induced , Exanthema/physiopathology , Hand-Foot Syndrome/etiology , Hand-Foot Syndrome/physiopathology , Humans , Mucositis/chemically induced , Mucositis/physiopathology , Neoplasms/complications , Skin Diseases/chemically induced , Skin Diseases/classification , Small Molecule Libraries/therapeutic use
3.
Immunotherapy ; 8(12): 1437-1446, 2016 12.
Article in English | MEDLINE | ID: mdl-28000535

ABSTRACT

Immune checkpoint inhibitors (ICI) represent a new revolutionary weapon in the armamentarium of anti-cancer therapies. The side effects of these new agents represent a new challenge for oncologists; they are usually unpredictable and sometimes life threatening, if not managed rapidly and adequately. The most frequent side effects are the dermatologic, but they are usually low grade side effects and consequently easily manageable. Rash, pruritus and vitiligo are the most frequent dermatologic side effects. We aimed in this review to describe first all the dermatologic side effects of ICI according to the subtype of ICI and combination therapies in the clinical trials, then to report all the rare case reports dermatologic side effects, and finally to present the management algorithm of these side effects.


Subject(s)
Antineoplastic Agents/therapeutic use , Costimulatory and Inhibitory T-Cell Receptors/antagonists & inhibitors , Drug-Related Side Effects and Adverse Reactions/therapy , Exanthema/therapy , Immunotherapy/methods , Neoplasms/therapy , Pruritus/therapy , Algorithms , Animals , Antineoplastic Agents/adverse effects , Clinical Trials as Topic , Disease Management , Exanthema/etiology , Humans , Immunotherapy/adverse effects , Neoplasms/complications , Neoplasms/immunology , Pruritus/etiology , Vitiligo/etiology , Vitiligo/therapy
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