ABSTRACT
Fifty-four (54) unrelated patients with Mediterranean Kaposi's sarcoma (MKS) and 8 patients members of 4 unrelated families with familial MKS were serotyped for HLA-A,B and DR antigens. The diagnosis was histologically confirmed and all patients were negative for anti-HIV antibodies. An increased frequency of HLA-B18 (44.4% vs 14.2% in the controls, p < 0.001, RR = 4.8) and HLA-DR5 (57.6% vs 37.2% in the controls, p < 0.025, RR = 2.29) was observed in the group of patients with MKS. Seven (7) of the 8 family members with FMKS possessed HLA-DR5, and the affected members in the 3 families shared a common haplotype which included HLA-DR5. These findings support the hypothesis that genetic factors linked to HLA-DR5 antigen may contribute to the pathogenesis of MKS.
Subject(s)
HLA Antigens/analysis , Sarcoma, Kaposi/genetics , Adult , Aged , Aged, 80 and over , Disease Susceptibility/immunology , Female , Genetic Predisposition to Disease , Greece/epidemiology , HLA Antigens/genetics , HLA-DR5 Antigen/analysis , HLA-DR5 Antigen/genetics , Humans , Incidence , Male , Middle Aged , Prospective Studies , Sarcoma, Kaposi/classification , Sarcoma, Kaposi/epidemiology , Sarcoma, Kaposi/immunologyABSTRACT
In an epidemiologic study in 17 villages from different areas of Greece, 2898 persons were examined in order to find possible relations between HBSAg prevalence, altitude and endemic goitre morbidity. A lower prevalence with a significant difference was found in areas with a high altitude as compared with those with a low one, in endemic goitre than non-endemic areas, and in low altitude endemic than in low altitude non-endemic areas. Goitrous subjects had a lower HBSAg prevalence than non-goitrous subjects, but the difference was of borderline significance. The results can probably be explained by the presence of an environmental factor associated with altitude acting together with a host factor predisposing to endemic goitre and favouring the immunity to HBV infection.
