ABSTRACT
Since the publication of the above article it has been noted that the author S O'Brien should have been listed as CS O'Brien. The authors should therefore appear as follows: R Dutia, M Embrey, CS O'Brien, RA Haeusler, KK Agénor, P Homel, J McGinty, RP Vincent, J Alaghband-Zadeh, B Staels, CW le Roux, J Yu and B Laferrère The corrected article html and online pdf versions have been amended. The authors wish to apologise for any inconvenience caused.
ABSTRACT
INTRODUCTION: Gastric bypass surgery (GBP) leads to sustained weight loss and significant improvement in type 2 diabetes (T2DM). Bile acids (BAs), signaling molecules which influence glucose metabolism, are a potential mediator for the improvement in T2DM after GBP. This study sought to investigate the effect of GBP on BA levels and composition in individuals with T2DM. METHODS: Plasma BA levels and composition and fibroblast growth factor (FGF)-19 levels were measured during fasting and in response to an oral glucose load before and at 1 month and 2 years post GBP in 13 severely obese women with T2DM. RESULTS: A striking temporal change in BA levels and composition was observed after GBP. During the fasted state, BA concentrations were generally reduced at 1 month, but increased 2 years post GBP. Postprandial BA levels were unchanged 1 month post GBP, but an exaggerated postprandial peak was observed 2 years after the surgery. A significant increase in the 12α-hydroxylated/non12α-hydroxylated BA ratio during fasting and postprandially at 2 years, but not 1 month, post GBP was observed. Significant correlations between BAs vs FGF-19, body weight, the incretin effect and peptide YY (PYY) were also found. CONCLUSIONS: This study provides evidence that GBP temporally modifies the concentration and composition of circulating BAs in individuals with T2DM, and suggests that BAs may be linked to the improvement in T2DM after GBP.
Subject(s)
Bile Acids and Salts/metabolism , Diabetes Mellitus, Type 2/metabolism , Gastric Bypass , Hydroxylation , Obesity, Morbid/surgery , Weight Loss , Adult , Fasting/metabolism , Female , Humans , Middle Aged , Obesity, Morbid/metabolism , Peptide YY/metabolism , Postoperative Period , Postprandial Period , Prospective Studies , Time Factors , Treatment OutcomeABSTRACT
Surgical plugging and resurfacing are well established treatments of superior semicircular canal dehiscence, while capping with hydroxyapatite cement has been little discussed in literature. The aim of this study was to prove the efficacy of the capping technique. Charts of patients diagnosed with superior semicircular canal dehiscence were reviewed retrospectively. All patients answered the dizziness handicap inventory, a survey analyzing the impact of their symptoms on their quality of life. Capping of the dehiscent canal was performed via the middle fossa approach in all cases. Ten out of 22 patients diagnosed with superior semicircular canal dehiscence were treated with surgical capping, nine of which were included in this study. No major perioperative complications occurred. In 8 out of 9 (89%) patients, capping led to a satisfying reduction of the main symptoms. One patient underwent revision surgery 1 year after the initial intervention. Scores in the dizziness handicap inventory were lower in the surgically treated group than in the non-surgically treated group, but results were not statistically significant (P = 0.45). Overall, capping is a safe and efficient alternative to plugging and resurfacing of superior semicircular canal dehiscence.
Subject(s)
Evoked Potentials, Auditory, Brain Stem , Hydroxyapatites/therapeutic use , Hyperacusis/surgery , Labyrinth Diseases/surgery , Semicircular Canals/surgery , Vertigo/surgery , Adult , Audiometry, Pure-Tone , Cohort Studies , Female , Humans , Hyperacusis/etiology , Labyrinth Diseases/complications , Labyrinth Diseases/diagnostic imaging , Male , Middle Aged , Retrospective Studies , Semicircular Canals/diagnostic imaging , Tomography, X-Ray Computed , Treatment Outcome , Vertigo/etiology , Vestibular Evoked Myogenic Potentials , Young AdultABSTRACT
The greatest immediate opportunity in automobile safety lies in utilization of what is already available to the motorist-equipment he may already have on hand, belts specifically. Without any further expenditure of money and without any further delay, the motorist can reduce the risk of facial injury.
