Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 38
Filter
Add more filters










Publication year range
1.
J Clin Pathol ; 59(11): 1221-2, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17071811

ABSTRACT

Primary effusion lymphoma (PEL) was once defined as a body cavity-based lymphoma without identifiable contiguous tumour mass, but is now recognised as an independent clinicopathological entity. The case of a 67-year-old Japanese woman with PEL is reported, in which the clinical findings showed a pericardial effusion and multiple erythema on the hypogastrium and inguinal region. The histopathological findings showed a diffuse infiltration of large neoplastic B cells from the dermis to the subcutis. After the disappearance of pericardial effusion without any treatment, she received several rounds of chemotherapy to resolve the skin eruption, but she finally died from multiple organ failure. No tumour mass was observed during the course of her disease.


Subject(s)
Lymphoma, B-Cell/pathology , Skin Neoplasms/pathology , Aged , Fatal Outcome , Female , Humans , Lymphoma, B-Cell/complications , Pericardial Effusion/etiology , Skin Neoplasms/complications
2.
J Clin Pathol ; 58(7): 757-61, 2005 Jul.
Article in English | MEDLINE | ID: mdl-15976347

ABSTRACT

BACKGROUND: Apocrine carcinoma is rare and often occurs in the axilla. This is the second apocrine carcinoma arising in bilateral axillae with associated apocrine hyperplasia to be reported. AIMS/METHODS: Because benign apocrine tumours may be precursors of cancer, this case was investigated immunohistochemically and histologically, and a literature (English and Japanese) review undertaken of cases with coexistent malignant and benign apocrine tumours in the axilla to elucidate the relation between apocrine carcinoma and benign apocrine tumours. RESULTS: Only four cases of axillary apocrine carcinoma with benign apocrine tumours were identified in the literature. In each case, benign apocrine hyperplasia was situated within and surrounding the adenocarcinomatous nests. Staining for epithelial membrane antigen revealed three patterns: (1) poorly differentiated tumour cells showing strong cytoplasmic staining; (2) combined luminal surface and cytoplasmic staining of glandular cells; and (3) a strongly positive lineal staining pattern at the luminal membrane surface, comprising one or two apocrine hyperplastic secretory cells. The basal lesions of apocrine hyperplasia were strongly positive for alpha smooth muscle actin, whereas the periphery of adenomatous lesions showed weaker positive staining, even though the periphery of adenocarcinomatous lesions was negative. CONCLUSIONS: All five apocrine carcinomas with benign apocrine tumours occurred in elderly Japanese men who had bilateral benign apocrine tumours even if affected by unilateral axillary apocrine carcinoma. The immunohistochemical results support the notion that apocrine hyperplasia is a precursor of cancer and that apocrine carcinoma, adenoma, and hyperplasia may be successive steps in the linear progression to carcinoma.


Subject(s)
Adenocarcinoma, Papillary/pathology , Apocrine Glands/pathology , Precancerous Conditions/pathology , Sweat Gland Neoplasms/pathology , Adenoma, Sweat Gland/pathology , Aged , Aged, 80 and over , Axilla , Humans , Hyperplasia , Male
4.
J Clin Pathol ; 56(10): 795-7, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14514790

ABSTRACT

This report describes the case of a 76 year old man who suffered from febrile ulceronecrotic Mucha-Habermann disease (FUMHD). Despite this patient's typical clinical and histological findings, the fulminating course led to death. Polymerase chain reaction (PCR) analysis of the skin lesions showed that the infiltrating cells were monoclonal in origin and were from an aberrant clone. FUMHD is a very rare, febrile variant type of pityriasis lichenoides et varioliformis acuta, and is characterised by necrotic cutaneous ulcerations associated with high fever and systemic manifestations. Including this present case, only 18 cases of FUMHD have been reported. FUMHD can occur in both adults and children, although there are several differences between the manifestations of the disease in the two groups. One major difference is prognosis: all cases resulting in fatality are of the adult type, whereas no fatal cases have been reported among children. The aberrant clone detected by PCR may be responsible for host responses, resulting in the severe symptoms observed in this disorder.


Subject(s)
Pityriasis Lichenoides/pathology , Skin Ulcer/pathology , Aged , Clone Cells , Fatal Outcome , Fever/immunology , Fever/pathology , Gene Rearrangement, T-Lymphocyte , Humans , Male , Necrosis , Pityriasis Lichenoides/complications , Pityriasis Lichenoides/immunology , Polymerase Chain Reaction/methods , Shock/complications , Skin Ulcer/immunology , T-Lymphocytes/immunology
6.
Dermatology ; 203(3): 233-7, 2001.
Article in English | MEDLINE | ID: mdl-11701977

ABSTRACT

BACKGROUND: Rhabdomyolysis has been described most commonly after muscle injury but may also result from coma due to alcohol intake or drug abuse. Its clinical findings usually occur as muscular pain and swelling, but these symptoms are also seen in as many as 60% of patients with nontraumatic rhabdomyolysis. The diagnosis of slight nontraumatic rhabdomyolysis is often difficult to establish clinically. Few previous studies have reported cutaneous symptoms in nontraumatic rhabdomyolysis. OBJECTIVE: We attempted to elucidate a relationship between nontraumatic rhabdomyolysis and cutaneous eruption. METHODS: We studied 7 patients who were diagnosed as having massive to slight nontraumatic rhabdomyolysis with a cutaneous eruption in pressure areas at the first visit to our hospital between March 28, 1988, and June 27, 1998. RESULTS: They revealed wine-red-colored urine and elevated serum myogenic enzyme. Two patients complained of muscle pain. In all patients, cutaneous eruptions including well-demarcated erythema, bullae and deep ulcers were observed in areas of pressure. The pathological findings of 5 cutaneous eruptions revealed necrosis of sweat ducts and glands in the dermis. CONCLUSIONS: The pathogenesis of nontraumatic rhabdomyolysis and the cutaneous eruptions in coma patients has not been elucidated, but these conditions are due to similar factors; pressure and hypoxia are considered to be important causative factors for both. Cutaneous eruptions in the coma patient may be an important clinical symptom of nontraumatic rhabdomyolysis.


Subject(s)
Blister/etiology , Coma/complications , Erythema/etiology , Purpura/etiology , Rhabdomyolysis/complications , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged
7.
Acta Derm Venereol ; 81(5): 360-3, 2001.
Article in English | MEDLINE | ID: mdl-11800146

ABSTRACT

We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-encoded small ribonucleic acids and by polymerase chain reaction to Epstein-Barr virus DNA. The inflammatory cells in the ulcers were positive for T-cell marker. Our results suggest that the Epstein-Barr virus infection in T cells may participate in the pathogenesis of exaggerated mosquito hypersensitivity and in delayed healing of ulcers on the sites of mosquito-bite.


Subject(s)
Culicidae , Epstein-Barr Virus Infections/complications , Herpesvirus 4, Human/isolation & purification , Insect Bites and Stings/complications , Leg Ulcer/etiology , T-Lymphocytes/virology , Adolescent , Animals , DNA, Viral/isolation & purification , Epstein-Barr Virus Infections/immunology , Epstein-Barr Virus Infections/pathology , Herpesvirus 4, Human/genetics , Humans , In Situ Hybridization , Insect Bites and Stings/immunology , Insect Bites and Stings/pathology , Leg Ulcer/pathology , Leg Ulcer/virology , Male , Severity of Illness Index
8.
J Clin Pathol ; 52(6): 464-7, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10562817

ABSTRACT

AIMS: To investigate the relation between localised amyloidosis and immunocytic dyscrasia. METHODS: Open lung biopsy specimens from a 72 year old man with multiple nodules in the right middle and lower lung were stained with haematoxylin-eosin, Congo red, and antibodies against IgG, IgA, IgM, and kappa and lambda light chains. Semi-nested PCR amplification for the immunoglobulin heavy chain (IgH) gene was performed using consensus primers for the VDJ region of the IgH gene, FR3A, LJH, and VLJH. RESULTS: The biopsy specimens contained eosinophilic amorphous material stained with Congro red and anti-kappa light chain, and surrounded by inflammatory cells intermingled with plasma cells. Plasma cells in the adjacent amorphous material showed cytoplasmic staining with anti-kappa. Polymerase chain reaction revealed a discrete amplified band of apparently uniform size with background smear. CONCLUSIONS: Primary AL type localised amyloidosis involves local accumulation of monoclonal plasma cells and their secreted products, as in nodular cutaneous amyloidosis. Localised AL type nodular amyloidosis is a separate entity in amyloidosis.


Subject(s)
Amyloidosis/pathology , Lung Diseases/pathology , Lung/pathology , Plasma Cells/pathology , Polymerase Chain Reaction , Aged , Amyloidosis/immunology , Clone Cells , Humans , Immunoglobulin kappa-Chains/analysis , Immunohistochemistry , Lung/immunology , Lung Diseases/immunology , Male , Plasma Cells/immunology
10.
Br J Dermatol ; 139(3): 481-7, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9767295

ABSTRACT

Epstein-Barr virus (EBV)-associated T/natural killer (NK) cell lymphoma mainly shows nasal lesions, and has recently been shown to be associated with cutaneous T-cell lymphoma (CTCL). The detailed features of CTCL nasal metastasis have yet to be elucidated. We report clinicopathological findings for four cases of cutaneous T/NK cell lymphoma with metastasis to the nose. The four patients presented progressive involvement of nasal lesions of CTCL, an aggressive course and poor outcome. Their pathological and immunohistological findings were consistent with peripheral T/NK cell neoplasm and, in three of four cases, EBER-1 were apparently detected in lymphoma cells by in situ hybridization, and two of four cases were also positive for TIA-1. The polymerase chain reaction (PCR) results showed the identical band from the skin and nasal lesions of the two patients. We also reviewed the cases of similar clinical course and attempted to elucidate clinical, pathological, immunological and genotypic features. The 10 reported cutaneous T/NK cell lymphomas with nasal metastasis revealed a poor prognosis (nine of 10 died at 3-108 months). Six cases of nine showed a positive reaction to EBV, and six cases revealed T-cell receptor beta or -gamma rearrangement. These findings suggest that most cutaneous T/NK cell lymphoma with nasal metastasis are similar to nasal T-cell lymphoma associated with EBV infection. This type of cutaneous T/NK cell lymphoma likely to involve nasal lesions and skin cases seemed to have a poor prognosis.


Subject(s)
Lymphoma, T-Cell, Cutaneous/pathology , Nose Neoplasms/secondary , Skin Neoplasms/pathology , Adult , Aged , Fatal Outcome , Female , Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor , Humans , Male , Middle Aged , Nasal Cavity , Polymerase Chain Reaction
12.
Br J Dermatol ; 138(4): 652-4, 1998 Apr.
Article in English | MEDLINE | ID: mdl-9640373

ABSTRACT

Nodular localized cutaneous amyloidosis (NLCA) is a disorder characterized by deposition of amyloid derived from immunoglobulin light chains. We used semi-nested polymerase chain reaction (PCR) to analyse archival paraffin-embedded sections from a previous patient and from four additional, previously reported patients with NLCA to determine whether involvement of monoclonal plasma cells is a universal feature of this condition. The semi-nested PCR analysis revealed one or two amplified bands, around 100-120 bp, for all five cases of NLCA, although the yields varied from case to case. These results suggest that clonal expansion of plasma cells in NLCA may occur locally.


Subject(s)
Amyloidosis/pathology , Plasma Cells/pathology , Skin Diseases/pathology , Adult , Aged , Clone Cells/pathology , Female , Humans , Male , Middle Aged , Paraffin Embedding , Polymerase Chain Reaction
13.
Cutis ; 60(5): 246-8; quiz 250, 1997 Nov.
Article in English | MEDLINE | ID: mdl-9403243

ABSTRACT

We report the case of a 73-year-old woman with linear focal elastosis (LFE) associated with striae distensae. Yellow palpable striae were found extending horizontally in the lumbar region. The yellow striae appeared to be joined to striae distensae in the lateral sides of the yellow striae. Striae distensae were also present in regions other than the back but were not associated with yellow striae. Histologic examination of a yellow stria revealed a focal increase in elastic fibers in the dermis. Although there have been some unusual cases of LFE arising in women or in young persons, this disorder still predominantly affects aged men. A fairly uniform feature of LFE is its occurrence on the dorsal skin, suggesting involvement of this specific anatomical site in its pathogenesis. We suspect that LFE usually arises de novo in the skin, although striae distensae may also be a cause of it.


Subject(s)
Skin Diseases/pathology , Aged , Female , Humans , Male , Skin/pathology
14.
J Dermatol ; 24(9): 606-10, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9350109

ABSTRACT

A rudimentary meningocele, a variant of primary cutaneous meningioma, was seen on the scalp of a 9-month-old Japanese boy. Clinically, the lesion on the left parietal area was round, about 1.6 cm in diameter, alopecic, and slightly elevated. Histologically, the lesion, located from the dermis to the subcutis, consisted of scattered foci of meningothelial cells, an anastomosing network of empty spaces with psammoma bodies and collagen bodies, and small vessels. Immunohistochemically, the meningothelial cells were positive for vimentin and desmin. Ultrastructurally, they had elongated cytoplasmic processes, intermediate filaments in the cytoplasm, and desmosomal junctions.


Subject(s)
Meningocele/pathology , Humans , Infant , Magnetic Resonance Imaging , Male , Meningioma/pathology , Microscopy, Electron , Scalp , Skin Neoplasms/pathology
15.
Br J Dermatol ; 137(3): 418-21, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9349341

ABSTRACT

We report a 79-year-old woman with primary cutaneous plasmacytoma in whom polymerase chain reaction (PCR) was used to demonstrate the monoclonality of the tumour. Four years after presentation, further skin lesions occurred and PCR again showed evidence of monoclonality despite the histology being non-specific. The reported frequency of multiple primary cutaneous plasmacytoma is increasing, and the mortality rate of patients with multiple lesions is three times that of those with a solitary lesion. PCR may be a useful technique for assessing such patients at presentation.


Subject(s)
Plasmacytoma/genetics , Skin Neoplasms/genetics , Aged , Female , Gene Rearrangement , Genotype , Humans , Plasmacytoma/pathology , Polymerase Chain Reaction , Skin Neoplasms/pathology
17.
Br J Dermatol ; 135(4): 630-3, 1996 Oct.
Article in English | MEDLINE | ID: mdl-8915162

ABSTRACT

We report nodular localized cutaneous amyloidosis arising in a 74-year-old woman as a single nodule at the left angle of the mouth. Histological examination revealed eosinophilic material deposited in the dermis, identified as amyloid by staining with Dylon stain, and antiamyloid P component, and by electron microscopy. The amyloid material was further determined immunohistochemically to be of AL fibril protein type derived from lambda light chains. Infiltrating plasma cells, around blood vessels in the dermis, stained monotypically with anti-lambda antibody, suggesting plasma cell monoclonality. Semi-nested polymerase chain reaction (PCR), for rearrangement of immunoglobulin heavy chain gene using paraffin-embedded sections, yielded two distinct amplified bands, indicating monoclonality of the infiltrating plasma cells. These findings support the hypothesis that primary localized nodular amyloidosis involves local accumulation of monoclonal plasma cells and their secreted products. The two amplified bands observed on PCR may, in the present case, reflect abnormal secretion of immunoglobulin light chains.


Subject(s)
Amyloidosis/immunology , Facial Dermatoses/immunology , Plasma Cells/immunology , Aged , Amyloidosis/pathology , Base Sequence , Facial Dermatoses/pathology , Female , Genes, Immunoglobulin , Humans , Molecular Sequence Data , Polymerase Chain Reaction
19.
J Dermatol ; 22(8): 611-9, 1995 Aug.
Article in English | MEDLINE | ID: mdl-7560462

ABSTRACT

Primary cutaneous meningioma (PCM) is a rare tumor whose pathogenesis is quite obscure. We reported PCMs occurring on almost the same occipital region of two siblings studied by histology, immunohistochemistry, and electron microscopy. Both lesions were attached to duras, but extracranial. One lesion was histologically diagnosed as meningothelial meningioma; its tumor cells showed electron microscopically interdigitating cytoplasmic processes with junctional complexes. The other was interpreted as fibroblastic meningioma; its tumor cells were arranged linearly in a stepping-stone arrangement and had small dense bodies in the cytoplasm. The tumor cells stained positively with anti-vimentin antibody. Both lesions had adenomatous hyperplasia of the eccrine glands. Although the histologic and electron microscopic features of these two lesions slightly differed from each other, their pathogenesis was essentially considered to be acoelic or rudimentary meningocele.


Subject(s)
Meningioma/genetics , Scalp/pathology , Skin Neoplasms/genetics , Adolescent , Cytoplasm/ultrastructure , Dura Mater/pathology , Eccrine Glands/pathology , Female , Humans , Hyperplasia , Immunohistochemistry , Male , Meningocele/pathology , Microscopy, Electron , Vimentin/analysis
20.
J Invest Dermatol ; 104(4): 526-9, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7706771

ABSTRACT

The objective of this study was to test the hypothesis that spontaneous regression of Shope papillomas involves tumor necrosis factor-alpha and apoptotic cell death of the papilloma cells. In situ hybridization using RNA probes of rabbit tumor necrosis factor-alpha revealed tumor necrosis factor-alpha mRNA in most of the numerous mononuclear cells infiltrating the upper dermis of regressing papillomas and at the dermoepidermal junction. Such cells in progressing papillomas were much fewer in number and were located in the deeper dermis. In situ terminal deoxynucleotidyl transferase assay demonstrated DNA strand breaks in many scattered epidermal keratinocytes of regressing papillomas but in only a few thin layers just beneath the horny layer in progressing papillomas. Electron microscopy demonstrated that regressing papillomas contained many apoptotic bodies and keratinocytes showing apoptotic changes such as chromatin condensation, degradation of condensed nuclei, surface protuberances, and a filamentous degeneration, as well as infiltrating lymphocytes and macrophages. We propose that tumor necrosis factor-alpha produced by infiltrating mononuclear cells probably plays a role in the papilloma regression.


Subject(s)
Apoptosis , Cottontail rabbit papillomavirus , Neoplasm Regression, Spontaneous , Papilloma/pathology , Papillomavirus Infections/pathology , Tumor Necrosis Factor-alpha/genetics , Tumor Virus Infections/pathology , Animals , DNA Nucleotidylexotransferase/analysis , In Situ Hybridization , Microscopy, Electron , Papilloma/metabolism , Papilloma/ultrastructure , RNA, Messenger/analysis , Rabbits
SELECTION OF CITATIONS
SEARCH DETAIL
...