ABSTRACT
Butyl hydroxy toluene reduced gastric erosion due to acetylsalicylic acid in the rat, but not the antiinflammatory, anti-pyretic and analgesic activity. By itself, BHT exhibited activity only in the test on analgesia.
Subject(s)
Aspirin/antagonists & inhibitors , Butylated Hydroxytoluene/pharmacology , Stomach/drug effects , Analgesia , Animals , Aspirin/therapeutic use , Aspirin/toxicity , Carrageenan , Edema/drug therapy , Fever/drug therapy , Male , Rats , Rats, Inbred StrainsABSTRACT
Prostaglandin E2 (PGE2) and PGF2 beta decreased the gastric erosive activity of orally administered indomethacin in a dose-dependent manner, when given as a continuous intravenous infusion in the conscious rat. PGE2 protected both during the initial stage of erosion induction and during the later outgrowth to larger erosions. Moreover PGE2 was able to stop the eroding process at any stage as long as the infusion continued. Both PGs were protective only in doses which also reduced the histamine-stimulated acid secretion. PGE2 protected the stomach against indomethacin-induced erosions even in the presence of exogenously administered acid. An infusion of PGE2 stimulated the secretion of bicarbonate in the stomach during some minutes but had no effect during prolonged infusion. These results suggest that, although effects on secretion of acid and bicarbonate were found, these effects cannot be the (only) explanation for the cytoprotective effects observed. Furthermore the protective effect of PGE2 is not confined to any specific stage of the development of indomethacin-induced gastric injury.
Subject(s)
Bicarbonates/metabolism , Gastric Acid/metabolism , Gastric Mucosa/drug effects , Indomethacin/antagonists & inhibitors , Prostaglandins E/pharmacology , Prostaglandins F/pharmacology , Animals , Dinoprost , Dinoprostone , Gastric Juice/metabolism , Gastric Mucosa/metabolism , Gastric Mucosa/pathology , Indomethacin/toxicity , Infusions, Parenteral , Male , Rats , Rats, Inbred StrainsABSTRACT
Interactions between indomethacin (INDO) and paracetamol (PAR) with regard to their anti-inflammatory, anti-pyretic and analgesic activities were studied in rats. The anti-inflammatory and anti-pyretic effects of INDO and PAR were additive. Although antagonism was observed in the analgesic test, the effect of the combination was not inferior to that of PAR alone.
Subject(s)
Acetaminophen/pharmacology , Indomethacin/pharmacology , Animals , Dose-Response Relationship, Drug , Drug Combinations , Drug Interactions , Male , Pain/physiopathology , Rats , Rats, Inbred Strains , Sensory Thresholds/drug effectsABSTRACT
Using ex vivo incubation of mucosal strips the production of prostaglandins (I2- and E-like PGs) in the rat stomach was demonstrated by bioassay. Indomethacin inhibited this PG synthesis 1 and 4 h after oral drug administration. Paracetamol stimulated the production of PGs when given by itself but could not prevent the inhibitory action of indomethacin. Protection of the stomach by paracetamol against the injuring effect of indomethacin is therefore not due to preservation of the production of protective PGs.
