ABSTRACT
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity anti-rubella IgG and were regarded as cases of reinfection.
Subject(s)
Antibodies, Viral/immunology , Immunoenzyme Techniques/methods , Immunoglobulin G/immunology , Pregnancy Complications, Infectious/epidemiology , Rubella Vaccine/adverse effects , Rubella virus/immunology , Rubella/epidemiology , Adolescent , Adult , Antibodies, Viral/blood , Antibody Affinity/immunology , Chi-Square Distribution , Female , Humans , Immunoenzyme Techniques/standards , Immunoglobulin G/blood , Iran/epidemiology , Mass Vaccination/adverse effects , Mass Vaccination/methods , Medical Errors/statistics & numerical data , Predictive Value of Tests , Pregnancy , Pregnancy Complications, Infectious/blood , Pregnancy Complications, Infectious/immunology , Pregnancy Complications, Infectious/virology , Rubella/blood , Rubella/immunology , Rubella/virology , Rubella Vaccine/immunology , Seroepidemiologic Studies , Statistics, NonparametricABSTRACT
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity antirubella IgG and were regarded as cases of reinfection