[Control of parturition in swine. 2. Study results of parturition synchronization in swine with the prostaglandin analog cloprostenol (I.C.I. 80.996: Estrumate)]. / Zur Beeinflussung der Geburt beim Schwein. 2. Mitteilung: Ergebnisse von Untersuchungen zur Partussynchronisation beim Schwein mittels des Prostaglandinanalogons Cloprostenol (I.C.I. 80.996: Estrumate).

Premature parturition was induced in 115 of 121 sows (95%) that had been given injections of 150 microgram or 200 microgram of "Estrumate", a prostaglandin analogues, on the 112th and 113th days of gestation. The average time that elapsed between injection and parturition of those 115 animals was 27.2 +/- 7.7 hours, with no difference being observed between gilts, on the one hand, and old sows, on the other. The time of gestation of the treated animals was shortened with significance from 114.6 +/- 1.6 days for the controls to 113.2 +/- 0.4 days. The average duration of parturition proper was 3.7 +/- 2.2 hours, the average litter being 11.2 +/- 3.3 piglets. The total number of piglets born was 1,320, with stillbirths accounting for 4.17%. The average weight at birth, 1,330 +/- 210 g, and the weight at weaning did not differ from weight figures recorded from the controls. The courses of parturition and puerperium were in agreement with normal biological standards. The sows treated were tested for their blood counts close to full term and for their endometrial histomorphology after weaning, with no side effects of "Estrumate" treatment being established. The behaviours of progesterone, 17-beta oestradiol, and cortisol in serum of "Estrumate"-treated sows were investigated, and congruence was established between spontaneous and prostaglandin-induced parturitions, which was in agreement with international literature. The conclusion is that 150 micrograms of 'Estrumate", administered to swine, after the 11th day of gestation has very good labour-inducing effects and ensures normal physiological parturition and piglet development.

[Trials of rut induction with prostaglandin F2alpha in gilts]. / Versuche zur Brunstinduktion mit Prostaglandin F2alpha bei Jungasauen.

The possibility of oestrus induction by means of F-2-alpha prostaglandin was checked on nine gilts. The animals received intramuscular injections of 7.5 mg of 10 mg of PG F2alpha on the tenth or twelfth day of cycle. The sexual behaviours of the animals was followed up, and after slaughter followed macroscopic assessment of the ovaries as well as histomorphological and histochemical examinations of the uterus wall. The results have shown that no oestrus or ovulation could be induced by such injection on the tenth or twelfth day of cycle. Regression of corpora lutea and follicle growth five days following application on the twelfth day of cycle were somewhat faster than the same phenomena when observed following injection on the tenth day. However, oestrus and ovulation failed throughout to occur earlier than they would have occurred any way without any treatment. The cycle was not shortened by application of F-2-alpha prostaglandin.

[Control of swine parturition. 1. Results of clinical, histological and hematological studies of parturition induction in swine using prostaglandin F2 alpha]. / Zur Beeinflussung der Geburt beim Schwein. 1. Mitteilung: Ergebnisse klinischer, histologischer und hämatologischer Untersuchungen zur Partusinduktion beim Schwein mittels Prostaglandin F2 alpha.

Parturition was induced to 23 sows on the 112th day of pregnancy by intramuscular injection of 7.5 mg PGF2 alpha (Dinoprost-Upjohn Co.). Onset of parturition was achieved within 27 hours and 52 minutes +/- four hours and 54 minutes in 21 animals (91.3 per cent). Average litter size was 11.33 piglets, with parturition time per litter having been five hours and 45 minutes +/- two hours and 39 minutes. Stillbirths accounted for 6.3 per cent. The average birth weight, 1.245 g +/- 264 g did not differ with significance from that of the controls. The physiological process accompanying parturition is described in greater detail. Unobstructed re-intergration with further reproduction of animals which had received PGF2 alpha treatment is established with hard evidence on the basis of clinical examination of oestrus, ovulation, conception, and farrowing rates as well as by histological examination of the endometrium. Alterations in the blood state recorded from animals with PGF2 alpha treatment close to full term were identical with those recorded from untreated animals.

[Results of experimental studies to control birth in swine]. / Ergebnisse experimenteller Untersuchungen zur Beeinflussung der Geburt beim Schwein.

An experiment was applied to ovulation-synchronised gilts and old sows. Mean values of pregnancy time were almost one and the same. Variations between the 111th and 117th days were exhibited within the control group. The test animals, however, farrowed on the 109th, 110th, and 111th days within spans of three days (113th to 115th day of pregnancy), following intramuscular injection of 75 mg DXMS. Intramuscular injection of 5 mg prostaglandin F2alpha on the 112th day of pregnancy triggered parturition within 25-36 hours in ten of 13 treated sows, whereas 19 of 20 sows gave birth within 27.7 +/- 5.1 hours in response to injection of 7.5 mg PGF2alpha.