Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Isr Med Assoc J ; 9(6): 439-42, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17642390

ABSTRACT

BACKGROUND: Mucositis and dermatitis are frequently encountered in patients treated with radiochemotherapy. Dead Sea products that contain minerals and other properties have proven effective in treating various skin diseases. OBJECTIVES: To evaluate the effectiveness of Dead Sea products in reducing acute radiochemotherapy-induced side effects in patients with head and neck cancer. METHODS: In this phase 2 study we compared the outcomes in 24 treated patients and 30 conventionally treated patients matched for age, tumor site, and type of treatment. The Dead Sea products comprised a mouthwash solution (Lenom) and a skin cream (Solaris) used three times daily for 1 week before, during, and up to 2 weeks after completion of radiotherapy. Mucositis and dermatitis were evaluated using common toxicity criteria. RESULTS: Thirteen treated patients (54%) had grade 1-2 and none had 3-4 mucositis, while 17 controls (57%) had grade 1-2 and 4 (13%) had grade 3-4 mucositis. Thirteen treated patients (54%) had grade 1-2 dermatitis; there was no instance of grade 3-4 dermatitis, while 11 patients in the control group (37%) had grade 1-2 and 5 (17%) had grade 3-4 dermatitis. More patients in the control arm needed a break than did patients in the treatment the control arm needed a break than did patients in the treatment arm (P = 0.034). CONCLUSIONS: The two Dead Sea products tested decreased skin and mucosal toxicity in head and neck cancer patients receiving radiochemotherapy.


Subject(s)
Dermatitis/prevention & control , Emollients/therapeutic use , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/radiotherapy , Mouthwashes/therapeutic use , Mucositis/prevention & control , Treatment Outcome , Acute Disease , Adult , Aged , Aged, 80 and over , Chemoprevention , Dermatitis/etiology , Female , Humans , Israel , Male , Middle Aged , Mineral Waters , Mucositis/etiology , Mucous Membrane/drug effects , Mucous Membrane/radiation effects , Oceans and Seas , Skin/drug effects , Skin/radiation effects
SELECTION OF CITATIONS
SEARCH DETAIL
...