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1.
Plasma carnitine in HIV-associated neuropathy.
Simpson, D M; Katzenstein, D; Haidich, B; Millington, D; Yiannoutsos, C; Schifitto, G; McArthur, J.
AIDS ; 15(16): 2207-8, 2001 Nov 09.
Article in English | MEDLINE | ID: mdl-11684949

Subject(s)
Carnitine/blood , HIV Infections/complications , Nerve Growth Factor/therapeutic use , Peripheral Nervous System Diseases/drug therapy , Anti-HIV Agents/adverse effects , Dideoxynucleosides/adverse effects , HIV Infections/drug therapy , Humans , Nerve Growth Factor/genetics , Peripheral Nervous System Diseases/chemically induced , Reverse Transcriptase Inhibitors/adverse effects
2.
Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy.
Schifitto, G; Yiannoutsos, C; Simpson, D M; Adornato, B T; Singer, E J; Hollander, H; Marra, C M; Rubin, M; Cohen, B A; Tucker, T; Koralnik, I J; Katzenstein, D; Haidich, B; Smith, M E; Shriver, S; Millar, L; Clifford, D B; McArthur, J C.
Neurology ; 57(7): 1313-6, 2001 Oct 09.
Article in English | MEDLINE | ID: mdl-11591856

ABSTRACT

HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.


Subject(s)
Acquired Immunodeficiency Syndrome/complications , Nerve Growth Factor/administration & dosage , Peripheral Nervous System Diseases/drug therapy , Humans , Pain Measurement , Peripheral Nervous System Diseases/virology , Recombinant Proteins/administration & dosage
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