ABSTRACT
BACKGROUND: Alloimmune-mediated refractoriness to platelet transfusion is most commonly due to antibody to HLA antigens in multiply transfused or multiparous patients. Published reports of poor transfusion response due to antibodies to platelet-specific antigens are rare and often confounded by the presence of coexistent antibodies against HLA antigens. CASE REPORT: A case is presented of a multiparous woman with acute myelogenous leukemia whose sole cause of transfusion refractoriness was antibody to platelet antigen HPA-1a. She responded dramatically to HPA-1a-negative platelet transfusion. CONCLUSION: This case provides strong serologic and clinical evidence that platelet transfusion refractoriness may result from antibodies to platelet-specific antigens.
Subject(s)
Antigens, Human Platelet/immunology , HLA Antigens/immunology , Isoantibodies/adverse effects , Platelet Transfusion/methods , Female , Humans , Integrin beta3 , Isoantibodies/blood , Leukemia, Myeloid, Acute/blood , Leukemia, Myeloid, Acute/therapy , Middle Aged , Platelet Count , Platelet Transfusion/standards , Treatment FailureABSTRACT
Medical and hospital facilities, including hospital blood banks, may be involved in various aspects of tissue banking. A key issue in running a successful tissue bank is understanding the scope of activity performed. The steps involved in collection, processing, storage, and distribution are reviewed, and potentially applicable rules and regulations and practical issues of tissue banking are discussed. In addition, "industry" standards that focus on storage and distribution of tissue for transplantation are summarized.
