ABSTRACT
Distribution and retention of mercury and selenium was studied in rats exposed repeatedly to HgCl2 injections (0.5 mg Hg/kg to the tail vein every other day) and intragastrically to Na2SeO3 (0.5 mg Se/kg every day), applying combined and separate administration of these metals for 2 weeks. Whole-body retention of mercury in the presence of selenium was augmented by 20% and that of selenium in the presence of mercury by 4% with respect to the administered dose. Combined administration of mercuric chloride and sodium selenite brought about damage to the epithelial cells of renal proximal convolutions and formation of protein casts in their lumen. These changes had the same pattern as those induced by administration of mercuric chloride alone, but the intensity was lower. Submicroscopic studies revealed that repeated combined administration of sodium selenite and mercuric chloride did not completely abolish the mercury-induced mitochondrial swelling and contributed to chromatin destruction in the hepatocyte nuclei.
Subject(s)
Kidney/pathology , Liver/pathology , Mercury/metabolism , Selenium/metabolism , Animals , Female , Mercury Poisoning/pathology , Organ Size/drug effects , Rats , Selenium/poisoningABSTRACT
The authors report a case in which the last cranial nerves were damaged with development of the Collet-Sicard-Villaret syndrome. The cause was metastasis of clear cell renal carcinoma. The syndrome is extremely rare. The fairly long, intermittent course in this case deserves attention.
Subject(s)
Cranial Nerves/pathology , Horner Syndrome/pathology , Kidney Neoplasms/pathology , Mesonephroma/pathology , Paralysis , Aged , Humans , Male , Neoplasm Metastasis , Syndrome , Vocal Cord ParalysisABSTRACT
Two cases of hemangiosarcoma of the liver and spleen are described. In the first case, a great number of cavernous blood vessels has been found and this, according to the authors, may support the idea that the tumour aroses within the benign hemangioma. In the other case a thrombocytopenia, a rare complication of the liver hemangioblastoma, has been found. It should be stressed that in spite of a malignant nature of these tumours, neoplastic foci were limited only to the liver and the spleen.