1.
Cancer Genet Cytogenet
; 81(1): 38-41, 1995 May.
Article
in English
| MEDLINE
| ID: mdl-7773958
ABSTRACT
We describe a newborn with acute monocytic leukemia who underwent spontaneous remission. Chromosomal analysis of this patient's leukemic blasts identified a translocation between 5q31 and 6q21. Chromosome 5 has been implicated in adult leukemogenesis but only rarely in childhood leukemia. Several hematopoietic growth factors and growth factor receptors have been mapped to the long arm of chromosome 5. This report discusses the possible role of these gene products in inducing leukemia in our index case.
Subject(s)
Chromosomes, Human, Pair 5 , Chromosomes, Human, Pair 6 , Leukemia, Monocytic, Acute/congenital , Leukemia, Monocytic, Acute/genetics , Translocation, Genetic/genetics , Bone Marrow/pathology , Female , Humans , Infant, Newborn , Karyotyping , Leukemia, Monocytic, Acute/pathology , Remission, Spontaneous
2.
J Pediatr
; 125(3): 490-2, 1994 Sep.
Article
in English
| MEDLINE
| ID: mdl-7520935
ABSTRACT
Three adult patients with beta-thalassemia intermedia were treated with hydroxyurea. Each had a significant but transient rise in total hemoglobin level associated with a variable increase in hemoglobin F.
Subject(s)
Hydroxyurea/therapeutic use , beta-Thalassemia/drug therapy , Administration, Oral , Adult , Erythrocyte Indices/drug effects , Female , Fetal Hemoglobin/analysis , Hemoglobins/analysis , Humans , Hydroxyurea/administration & dosage , Male , beta-Thalassemia/blood
3.
Semin Perinatol
; 14(5): 374-83, 1990 Oct.
Article
in English
| MEDLINE
| ID: mdl-2287953
