ABSTRACT
Inflammatory foci induced by murine cytomegalovirus infection in normocholesterolemic mice were present temporarily in the aortic wall, but some of these foci developed into advanced lesions that persisted late after infection. The early foci induced by virus infection were significantly exacerbated following a single inoculation with Chlamydia pneumoniae.
Subject(s)
Aortitis/virology , Chlamydophila Infections/immunology , Chlamydophila pneumoniae , Cytomegalovirus Infections/immunology , Pneumonia, Bacterial/immunology , Animals , Aortitis/microbiology , Aortitis/pathology , Arteriosclerosis/immunology , Arteriosclerosis/pathology , Chlamydophila Infections/pathology , Chlamydophila Infections/virology , Cholesterol/blood , Cytomegalovirus Infections/microbiology , Cytomegalovirus Infections/pathology , Male , Mice , Mice, Inbred BALB C , Pneumonia, Bacterial/pathology , Pneumonia, Bacterial/virologyABSTRACT
The authors report a case of collagenous sprue. This condition is characterized by coeliac type small bowel malabsorption, resistant to gluten free diet and other therapeutic efforts, associated with poor prognosis. The diagnosis depends on the histological demonstration of extensive collagenization of the lamina propria in the flat jejunal mucosa. This disease must be kept in mind at differential diagnosis of chronic diarrhea with progressive malabsorption, especially if it is resistant to gluten withdrawal in contrast to conventional coeliac disease.
Subject(s)
Celiac Disease/pathology , Collagen/metabolism , Intestinal Mucosa/pathology , Biopsy , Celiac Disease/therapy , Humans , Ileum/pathology , Jejunum/pathology , Male , Microscopy, Electron , Middle AgedABSTRACT
The authors report the first case of collagenous sprue in Hungary. This condition is characterized by coeliac type small bowel malabsorption, resistant to gluten free diet and other therapeutic efforts, associated with poor prognosis. The diagnosis depends on the histological demonstration of extensive collagenization of the lamina propria in the flat jejunal mucosa. This disease must be kept in mind at differential diagnosis of chronic diarrhoea with progressive malabsorption, especially if it is resistant to gluten withdrawal than conventional coeliac disease.
Subject(s)
Celiac Disease/metabolism , Age Factors , Celiac Disease/physiopathology , Collagen/metabolism , Humans , Male , Middle AgedABSTRACT
Thirty-two cases of malignant Müllerian tumours of the uterus of the mixed mesodermal type were investigated. Histological examinations were performed on tissue obtained during curettage or biopsy and/or surgical removal of the uterus; in 4 cases postmortem examination was also carried out. The biphasic tumours of the uterus were classified into four groups and comprised 44% of alle uterine sarcomas. In 10 of the 28 cases in which uterine curettage or cervical biopsy was carried out, the final diagnosis was clarified when the tumorous uterus was removed. The prognosis was poorer for heterologous than for homologous tumours. In the heterologous group, the prognosis was better for the form with chondrosarcomatous features (2 patients are still alive after more than 5 years) than for the form containing striated muscle tissue (all 5 patients died within 1 year). Attention is drawn to the fact that the adenosarcoma should be considered a separate type; its prognosis was relatively good (2 such patients are still alive after more than 5 years).
