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1.
Synthesis and immunofluorescence assay of a new biotinylated paclitaxel.
Sambaiah, Thota; King, Ke Yung; Tsay, Shwu Chen; Mei, Nai Wen; Hakimclahi, Sharcon; Lai, Yiu Kay; Lieu, Chien Hui; Hwu, Jih Ru.
Eur J Med Chem ; 37(4): 349-53, 2002 Apr.
Article in English | MEDLINE | ID: mdl-11960670

ABSTRACT

7-(5'-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods; its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G(2)M phase only.


Subject(s)
Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/metabolism , Paclitaxel/chemical synthesis , Paclitaxel/metabolism , Taxoids , Fluorescent Antibody Technique , Fluorescent Dyes/chemistry , Humans , Microtubules/metabolism , Paclitaxel/analogs & derivatives , Tumor Cells, Cultured , U937 Cells
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