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Rev Med Interne ; 36(12): 843-7, 2015 Dec.
Article in French | MEDLINE | ID: mdl-25613810

ABSTRACT

INTRODUCTION: Paraneoplastic Cushing's syndrome is a rare cause of endogenous hypercortisolism attributable to ectopic ACTH secretion by non-pituitary tumors. Imaging and biochemical results are often inconclusive and differential diagnosis with Cushing's disease can then be challenging. Moreover, these tumors may be occult and difficult to find and thus the need of new imaging tools such as (18)FDG-PET scan and (18)DOPA-PET scan. CASE REPORT: We report a 50-year-old man who presented with very aggressive clinical features related to Cushing's syndrome. Biological work-up confirmed the hypercortisolism and was consistent with an ectopic ACTH secretion. Conventional localization techniques failed to show any tumor and bilateral adrenalectomy was performed because of life-threatening complications. Two years later, thoracic computed tomography reveals an 11 mm mass in the left lower pulmonary lobe, (18)FDG-PET scan found a non-specific mild hypermetabolism of the lung nodule, and the (18)DOPA-PET scan confirmed the high uptake of this nodule suggesting an endocrine carcinoma. Histology confirmed a typical carcinoid tumor. The tumor cells stained positive for ACTH, CD56, chromogranin and synaptophysin. CONCLUSION: This case illustrates the dilemma between the need for morphological diagnosis of the ectopic ACTH source and control of the life-threatening hypercortisolism. (18)FDG-PET scan and (18)DOPA-PET scan should be considered early as a secondary diagnostic tool when conventional imagery fails to show any tumor.


Subject(s)
ACTH Syndrome, Ectopic/etiology , Carcinoid Tumor/complications , Cushing Syndrome/etiology , Lung Neoplasms/complications , Paraneoplastic Syndromes/etiology , ACTH Syndrome, Ectopic/diagnosis , ACTH Syndrome, Ectopic/therapy , Cushing Syndrome/diagnosis , Cushing Syndrome/therapy , Humans , Male , Middle Aged , Paraneoplastic Syndromes/diagnosis , Paraneoplastic Syndromes/therapy
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