ABSTRACT
We describe a patient who suffered from chronic progressive granulomatous lung disease. He had no clinical or microbiological evidence of infection. After failure of treatment with interferon-gamma and trimethoprim-sulfamethoxazole, he responded dramatically to corticosteroids.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Antiviral Agents/pharmacology , Granulomatous Disease, Chronic/drug therapy , Interferon-gamma/pharmacology , Lung Diseases/congenital , Lung Diseases/drug therapy , Adrenal Cortex Hormones/pharmacology , Anti-Infective Agents/pharmacology , Child , Disease Progression , Drug Resistance , Granulomatous Disease, Chronic/immunology , Humans , Lung Diseases/pathology , Male , Treatment Outcome , Trimethoprim, Sulfamethoxazole Drug Combination/pharmacologyABSTRACT
We report 13 patients with 16 episodes of acute lobar nephronia diagnosed in a prospective study that was conducted among 210 hospitalized children with urinary tract infection. In 30 episodes of urinary tract infection, a hypoechogenic or hyperechogenic lesion was found. Twenty patients underwent computed tomography, and in 16 of them acute lobar nephronia was diagnosed. Evolution to renal abscess occurred in 25%. Prolonged intravenous antibiotic treatment was sufficient in all cases.
