ABSTRACT
Cryostorage of reproductive potential, in the form of ovarian cortex, for young women about to undergo cytotoxic therapies has been offered clinically for some time. However, the prospects of re-establishing reproductive function using this tissue remain unclear. We now report reproducible follicular development, oocyte retrieval and embryo development following heterotopic grafting of cryopreserved ovarian cortex which had been stored for over 10 years.
Subject(s)
Cryopreservation , Ovary/physiology , Ovary/transplantation , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Australia , Chorionic Gonadotropin, beta Subunit, Human/blood , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Estradiol/therapeutic use , Female , Follicle Stimulating Hormone/blood , Humans , Luteinizing Hormone/blood , Lymphoma, Large-Cell, Anaplastic/drug therapy , Prednisone/therapeutic use , Progesterone/blood , Sperm Injections, Intracytoplasmic , Transplantation, Autologous , Treatment Outcome , Vincristine/therapeutic useABSTRACT
We describe the case of a woman with some features of the MURCS (Müllerian duct aplasia, renal aplasia, and cervicothoracic somite dysplasia) association, along with a radial ray anomaly. She had fusion of two cervical vertebrae, and a unicornuate uterus as MURCS components; and thenar muscle hypoplasia and absent radial pulses reflecting radial ray elements. We review two similar cases from the literature. We discuss whether our case might represent an incomplete and variant form of the MURCS association, or an example of an overlap between the MURCS and VATER (vertebral, anal, tracheo-esophageal, radial) associations.
