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Bioorg Med Chem Lett
; 17(5): 1206-10, 2007 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-17188860
ABSTRACT
Aminoglycoside antibiotics target an internal RNA loop within the bacterial ribosomal decoding site. Here, we describe the synthesis and SAR of novel 3,5-diamino-piperidine derivatives as aminoglycoside mimetics, and show they act as inhibitors of bacterial translation and growth.