Dopamine, religiosity, and utilitarian moral judgment.

Our goal was to examine the relationship between biological and sociocultural factors that predict utilitarian moral judgment. Utilitarian moral judgments occur when a specific action is based on the outcome rather than its consistency with social norms. We predicted that (1) individuals with higher levels of dopamine will make more utilitarian decisions and (2) individuals who express greater religiosity will make less utilitarian judgments. We measured dopamine using spontaneous eyeblink rate, an indirect measure associated with striatal dopaminergic transmission. A total of 96 participants completed a utilitarian moral judgment task where they made judgments regarding nonmoral, impersonal, personal low-conflict, and personal high-conflict moral dilemmas. Then, participants completed a questionnaire measuring religiosity. We found a negative relationship between religiosity and the proportion of "yes" judgments participants made in the high-conflict personal dilemmas, which was consistent with our second hypothesis. None of our other hypotheses were supported. Understanding biological and cultural factors that relate to utilitarian moral judgment may also help in developing artificial intelligence that more closely mimic human behavior.

Neural correlates of cognitive reappraisal of positive and negative affect in older adults.

OBJECTIVES: Compromised regulation of negative and positive emotions is a common feature of psychopathology. Healthy aging relates to changes in affective processing, but older adults' regulation of positive affect is less well understood than regulation of negative affect. We examined the cognitive reappraisal of positive and negative affect in healthy younger and older adults, and the neural correlates of reappraisal among older adults. METHOD: Participants viewed negative, positive, and neutral IAPS images and were instructed to attend or reappraise their affective response. Younger and older adults (N = 31) in the behavioral pilot were asked to report on their affect after each image. Another group of older adults (N = 19) completed the same task while undergoing functional magnetic resonance imaging. RESULTS: Behaviorally, older adults were less effective than young adults at downregulating negative and positive affect. Older adults showed engagement of cognitive control regions when regulating negative affect, but not positive affect. Older adults showed increased, rather than decreased, activation in emotion appraisal regions when reappraising negative affect. DISCUSSION: These results may suggest that older adults are less engaged with negative stimuli ; however, future work is needed to address several limitations such as a limited sample size. In addition, we recommend future researchers expand on this work examining regulation of both positive and negative affect among older adults.

The Role of the Ventromedial Prefrontal Cortex in Purchase Intent Among Older Adults.

Older adults are frequently the targets of scams and deception, with millions of individuals being affected each year in the United States alone. Previous research has shown that the ventromedial prefrontal cortex (vmPFC) may play a role in vulnerability to fraud. The current study examined brain activation patterns in relation to susceptibility to scams and fraud using functional magnetic resonance imaging (fMRI). Twenty-eight healthy, community-dwelling older adults were subdivided into groups of impaired and unimpaired decision makers as determined by their performance on the Iowa Gambling Task (IGT). While in the scanner, the participants viewed advertisements that were created directly from cases deemed deceptive by the Federal Trade Commission (FTC). We then obtained behavioral measures involving comprehension of claims and purchase intention of the product in each advertisement. Contrasts show brain activity in the vmPFC was less correlated with purchase intention in impaired vs. unimpaired older adult decision makers. Our results have important implications for both future research and recognizing the possible causes of fraud susceptibility among older adults.

Individual differences in the neural signature of subjective value among older adults.

Some healthy older adults show departures from standard decision-making patterns exhibited by younger adults. We asked if such departures are uniform or if heterogeneous aging processes can designate which older adults show differing decision patterns. Thirty-three healthy older adults with varying decision-making patterns on a complex decision task (the Iowa Gambling Task) completed an intertemporal choice task while undergoing functional magnetic resonance imaging. We examined whether value representation in the canonical valuation network differed across older adults based on complex decision-making ability. Older adults with advantageous decision patterns showed increased activity in the valuation network, including the ventromedial prefrontal cortex (VMPFC) and striatum. In contrast, older adults with disadvantageous decision patterns showed reduced or absent activation in the VMPFC and striatum, and these older adults also showed greater blood oxygen level dependent signal temporal variability in the striatum. Our results suggest that a reduced representation of value in the brain, possibly driven by increased neural noise, relates to suboptimal decision-making in a subset of older adults, which could translate to poor decision-making in many aspects of life, including finance, health and long-term care. Understanding the connection between suboptimal decision-making and neural value signals is a step toward mitigating age-related decision-making impairments.

Functional neuroimaging of the Iowa Gambling Task in older adults.

OBJECTIVE: The neural systems most susceptible to age-related decline mirror the systems linked to decision making. Yet, the neural processes underlying decision-making disparities among older adults are not well understood. We sought to identify neural response patterns that distinguish 2 groups of older adults who exhibit divergent decision-making patterns. METHOD: Participants were 31 healthy older adults (ages 59-88, 53% female), defined as advantageous or disadvantageous decision-makers based on Iowa Gambling Task (IGT) performance, who completed an alternate version of the IGT while undergoing functional MRI. The groups were indistinguishable on neuropsychological testing. We contrasted the BOLD signal between groups during 3 phases of the decision-making process: Prechoice (preselection), Prefeedback (postselection), and Feedback (receipt of gains/losses). We further examined whether BOLD signal varied as a function of age in each group. RESULTS: We observed greater activation among the IGT-Disadvantageous relative to -Advantageous older adults in the prefrontal cortex during the early phases of the decision-making process (Prechoice), and in posterior brain regions (e.g., the precuneus) during the later phases (Prefeedback and Feedback). We also found that with increasing age, IGT-Advantageous older adults showed increasing activation in the prefrontal cortex during all phases and increasing activation in the posterior cingulate during earlier phases of the decision process. By contrast, the IGT-Disadvantageous older adults exhibited a reduced or reversed trend. CONCLUSIONS: These functional differences may be a consequence of altered reward processing or differing compensatory strategies between IGT-Disadvantageous and -Advantageous older adults. This supports the notion that divergent neurobiological aging trajectories underlie disparate decision-making patterns.