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Chemistry ; 21(25): 9034-8, 2015 Jun 15.
Article in English | MEDLINE | ID: mdl-25965348

ABSTRACT

Herein a new (11) C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, (11) CS2 , is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [(11) C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with (11) CS2 , which has potential applications as a positron emission tomography radioligand for cancer imaging.


Subject(s)
Benzoxazines/chemistry , Carbon Radioisotopes/chemistry , Parietal Lobe/chemistry , Radiopharmaceuticals/chemistry , Receptors, Progesterone/chemistry , Thiones/chemistry , Thiourea/chemical synthesis , Breast Neoplasms , Humans , Positron-Emission Tomography , Receptors, Progesterone/antagonists & inhibitors , Thiourea/chemistry
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