Perioperative complications after surgical treatment in degenerative adult de novo scoliosis.

BACKGROUND: Degenerative adult de novo (DAD) scoliosis appears characteristically in the sixth or seventh decade with symptoms of severe back pain and radiculopathy or spinal claudication. The aim of this study was to enhance the knowledge of perioperative complications and detect possible risk factors in this selective DAD scoliosis surgery. METHODS: This retrospective study included only patients with DAD scoliosis undergone correction spondylodesis with previous failure of conservative treatment. Excluded were patients with other types of scoliosis and previous fusion surgeries. Patient epidemiological data, medical comorbidities and treatments were included. Intraoperative data and perioperative complications were documented. Analyses regarding early, late and no complications were undertaken. RESULTS: A total of 92 patients with a mean age of 67.29 ± 7.93 years and clinical follow-up visits of minimum 12 months were included. On average, 5.26 ± 2.24 segments were fused. Early complications (e.g. wound healing defects, paresis, screw loosing) occurred in 23 patients and often required a re-operation. Cardiac arrhythmias, pacemaker and coumarin derivative therapies were associated with increased perioperative complications. The transforaminal lumbar interbody fusion technique was associated with early complications. Adjacent segment failure occurred in 36% and was the major late complication. Twenty patients did not have any complications in the minimum follow-up. CONCLUSIONS: This study analysed a selective DAD scoliosis collective and its' surgical treatment outcomes. It identified numerous perioperative complications (adjacent segment failure, postoperative paresis and epidural hematoma) and multiple possible predisposing risk factors (e.g. operative techniques and anti-coagulation therapies). This here gained information raises awareness in preoperative patient selection and preparation. Further studies in DAD scoliosis and a risk-adjusted patient selection/preparation are needed to improve treatment quality and outcomes.

Two-year follow-up after decompressive surgery with and without implantation of an interspinous device for lumbar spinal stenosis: a prospective controlled study.

STUDY DESIGN: Two-arm prospective controlled study. OBJECTIVE: The aim of our study was to prospectively assess the outcome of symptomatic lumbar spinal stenosis (LSS) treated with decompressive surgery alone in comparison with additional implantation of the Coflex interspinous device. SUMMARY OF BACKROUND DATA: In symptomatic LSS, decompression surgery is an established treatment. Recently, a number of interspinous devices have been introduced as an alternative to conventional surgical procedures. The theoretical aim of the Coflex device is to unload the facet joints, restore foraminal height, and provide stability to improve the clinical outcome. Published information is limited, and there are no data that prove the superiority of the implant in comparison with traditional surgical approaches. METHODS: Sixty-two patients with symptomatic LSS were treated with decompressive surgery; 31 of these patients received an additional Coflex device. Preoperatively and postoperatively, disability and pain scores were measured using the Oswestry Disability Index, the Roland-Morris Disability Questionnaire, the Visual Analog Scale, and the pain-free walking distance. Patients underwent postoperative assessments at 3, 6, 12, and 24 month including the above-mentioned scores and patient satisfaction. RESULTS: There was a significant improvement (P<0.001) in the clinical outcome assessed in the Oswestry Disability Index, the Roland-Morris Disability Questionnaire, the Visual Analog Scale, and the pain-free walking distance at all times of reinvestigation compared with the base line in both groups. Up to 2 years after surgery, there were no significant differences between both groups in all ascertained parameters, including the patient satisfaction and subjective operation decision. CONCLUSIONS: The results of this first prospective controlled study indicate that the additional placement of a Coflex interspinous device does not improve the already good clinical outcome after decompressive surgery for LSS in the 24-month follow-up interval.

Long-term follow-up after en bloc resection and reconstruction of a solitary paraganglioma metastasis in the first lumbar vertebral body: a case report.

INTRODUCTION: Paragangliomas are rare tumors that originate from the autonomic nervous system-associated paraganglia. They metastasize infrequently. Malignancy can only be demonstrated by the presence of chromaffin tissue at sites where it usually is not present, such as bone, lung or liver, or local recurrence after total resection of a primary mass. Paragangliomas within the central nervous system are usually intradural near the conus medullaris. The metastatic spread of a retroperitoneal paraganglioma to a vertebral body is extremely rare, and there are only a few cases reported in the literature. CASE PRESENTATION: We report the case of a 16-year-old Caucasian girl who had undergone resection of a retroperitoneal paraganglioma that measured 15 × 11.5 × 9.5 cm. After further staging, a solitary metastatic paraganglioma was detected in the first lumbar vertebral body. After initial chemotherapy, marginal en bloc resection and reconstruction were performed followed by radiotherapy. Histologic examination of the specimen revealed that the tumor cells did not show any response to preoperative chemotherapy, which is in line with a few other reports in the literature. Ten years after operative treatment, the patient is free of complaints, very satisfied with the result and without signs of local recurrence or distant metastases. CONCLUSION: We recommend en bloc spondylectomy and local radiotherapy in the treatment of solitary spinal metastatic paragangliomas.

Validity and reliability of an adapted german version of scoliosis research society-22 questionnaire.

STUDY DESIGN: Study to determine the internal consistency and validity of adapted German version of Scoliosis Research Society-22 (SRS-22) questionnaire. OBJECTIVE: To evaluate the validity and reliability of adapted German version of SRS-22 questionnaire. SUMMARY OF BACKGROUND DATA: The SRS-22 questionnaire was developed to assess the health-related quality of life for English-speaking patients with idiopathic scoliosis. For scientific purpose and standardized comparison of outcome studies for the treatment of idiopathic scoliosis its adaptation into German is necessary to respect cultural and lingual differences. METHODS: Translation/retranslation of the English version of the SRS-22 was conducted, and all steps for cross-cultural adaptation process were performed. Thus, SRS-22 questionnaire and previously validated Roland-Morris score were mailed to 222 patients who had been treated surgically or conservatively for idiopathic scoliosis. Seventy-eight patients (35%) responded to the first set of questionnaires and 54 of the first time responder returned their second survey. The median age of all patients who joined the study was 19 years. Measures of reliability namely, selectivity, internal consistency, and reproducibility were determined by Cronbach's alpha statistics and intraclass correlation coefficient, respectively. Concurrent validity was measured by comparing with an already validated questionnaire (Roland-Morris score). Measurement was made using the Spearman correlation coefficient. RESULTS: The study demonstrated satisfactory internal consistency with high Cronbach's alpha values for 4 of the corresponding domains (pain, 0.75; self-image, 0.84; mental health, 0.88; and satisfaction, 0.61). However, the Cronbach's alpha value for function/activity domain (0.67) was considerably lower than the original English questionnaire. For the same domains intraclass correlation coefficient demonstrating satisfactory test/retest reproducibility. CONCLUSION: The adapted German version of the SRS-22 questionnaire can be used to assess the outcome of treatment for German-speaking patients with idiopathic scoliosis.

Interobserver and intraobserver agreement of Lenke and King classifications for idiopathic scoliosis and the influence of level of professional training.

STUDY DESIGN: This is a blinded study of radiographs by observers with different levels of professional training. OBJECTIVES: To determine whether the level of professional training on nonmeasured and premeasured radiographs would affect reliability of Lenke's and King's classifications for adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Both classification systems have been studied for their reliability, mainly by observers with a high level of experience in orthopedics and scoliosis surgery using premeasured radiographs. METHODS: Examination of radiographs of 60 operative cases of adolescent idiopathic scoliosis was performed. On 5 occasions, 3 observers with a completely different degree of professional training measured and classified preoperative radiographs according to Lenke's or King's criteria. The results were determined by calculating the interobserver and intraobserver agreement and were quantified using two-rater and multirater kappa statistics. RESULTS: The Lenke and King classifications demonstrated poor to fair interobserver and good intraobserver agreement on nonmeasured radiographs. Both classifications demonstrated good to excellent interobserver agreement on premeasured radiographs. CONCLUSIONS: The results confirm that both classifications have a good reliability. On nonmeasured radiographs, the degree of professional training and the measurement process seem to influence the outcome. On premeasured radiographs, the interobserver agreement does not seem to be influenced by the level of professional training.

Anterior dual rod instrumentation in idiopathic thoracic scoliosis.

For anterior correction and instrumentation of thoracic curves single rod techniques are widely used. Disadvantages of this technique include screw pullouts, rod fractures and limited control of kyphosis. This is a prospective study of 23 consecutive patients with idiopathic thoracic scoliosis treated with a new anterior dual rod system. Aim of the study was to evaluate the safety and efficacy of this new technique in the surgical treatment of idiopathic thoracic scoliosis. To the best knowledge of the authors, this is the largest series on dual rod dual screw instrumentation over the entire fusion length in thoracic scoliosis. Twenty-three patients with an average age of 15 years were surgically treated with a new anterior dual rod system through a standard open double thoracotomy approach. Average clinical and radiological follow-up was 28 months (24-46 months). Fusion was carried out mostly from end-to-end vertebra. The primary curve was corrected from 66.6 degrees to 28.3 degrees (57.5% correction) with an average loss of correction of 2.0 degrees at Cobb levels and of 1.3 degrees at fusion levels. Spontaneous correction of the secondary lumbar curve averaged 43.2% (preoperative Cobb angle 41.2 degrees ). The apical vertebral rotation was corrected by 41.1% with a consecutive correction of the rib hump of clinically 66.7%. The thoracic kyphosis measured 29.2 degrees preoperatively and 33.6 degrees at follow-up. In seven patients with a preoperative hyperkyphosis of on average 47.3 degrees thoracic kyphosis was corrected to 41.0 degrees . This new instrumentation enables an entire dual rod instrumentation over the whole thoracic fusion length. It offers primary stability without the need of postoperative bracing. Dual screw dual rod instrumentation offers the advantages of a high screw pullout resistance, an increased overall stability and satisfactory sagittal plane control.

Spontaneous correction and derotation of secondary curves after selective anterior fusion of idiopathic scoliosis.

STUDY DESIGN: Clinical, rasterstereographic, and radiographic evaluation of spontaneous vertebral derotation of secondary curves in idiopathic scoliosis following selective anterior correction and fusion of the primary curve. OBJECTIVE: To quantify spontaneous vertebral derotation in secondary curves after selective anterior correction with attention to cosmetic outcome. SUMMARY OF BACKGROUND DATA: While the derotational effect of anterior instrumentation techniques on the instrumented curve is well understood, there is a paucity on data of the rotational behavior of the noninstrumented secondary curves. METHODS: A total of 43 patients with idiopathic scoliosis (16 with thoracic curves in group 1 and 27 with thoracolumbar/lumbar curves in group 2) underwent selective anterior instrumentation. Vertebral rotation was analyzed before surgery and, on average, 20 months after surgery using digital radiometric rotation analysis, back shape analysis with rasterstereography, and scoliometer measurement. RESULTS: In Group 1, there was a significant spontaneous vertebral derotation of the secondary lumbar curves by 14.2% (range from 12.7 degrees to 10.9 degrees) in the digital radiometric rotation analysis, surface derotation amounted to 49% (range from 9.6 degrees to 4.9 degrees) in the rasterstereography, and to 70% in the clinical scoliometer measurement (range from 8.0 degrees to 2.4 degrees ). In group 2, there was an increase of rotation of the noninstrumented secondary thoracic curves by 30% (range from 5.0 degrees to 6.5 degrees ) in digital radiometry, by 32.9% in the rasterstereography (range from 8.5 degrees to 11.3 degrees), and a 28.3% increase in scoliometer measurement (range from 6.0 degrees to 7.7 degrees). CONCLUSION: Selective anterior instrumentation and fusion of primary thoracic curves results in satisfactory spontaneous vertebral and high surface derotation of the secondary lumbar curves. However, in primary thoracolumbar or lumbar curves, an increase of both vertebral and surface rotation of the secondary thoracic curve was noted. This increase can impair cosmetic outcome.

Combined anterior and posterior instrumentation in severe and rigid idiopathic scoliosis.

A prospective clinical and radiographic evaluation of 33 consecutive patients with severe and rigid idiopathic scoliosis (average Cobb angle 93 degrees, flexibility on bending films 23%) were treated with combined anterior and posterior instrumentation with a minimum follow-up of 2 years. All patients underwent anterior release and VDS-Zielke Instrumentation of the primary curve. In highly rigid scoliosis, this was preceded by a posterior release. Finally, posterior correction and fusion with a multiple hook and pedicle screw construct was performed. Thirty patients were operated in one stage, three patients in two stages. Preoperative curves ranged from 80 to 122 degrees Cobb angle. Frontal plane correction of the primary curve averaged 67% with an average loss of correction of 2 degrees . The apical vertebral rotation of the primary curve was corrected by 49%. In all but three patients, sagittal alignment was restored. There were no neurological complications, deep wound infections or pseudarthrosis. Combined anterior and posterior instrumentation is safe and enables an effective three-dimensional curve correction in severe and rigid idiopathic scoliosis.

Dual-rod correction and instrumentation of idiopathic scoliosis with the Halm-Zielke instrumentation.

STUDY DESIGN: A prospective clinical and radiographic evaluation of 45 consecutive patients with idiopathic adolescent and adult scoliosis treated with anterior dual-rod Halm-Zielke instrumentation. OBJECTIVES: Clinical and radiographic evaluation with a minimum follow-up of 2 years. SUMMARY OF BACKGROUND DATA: Halm-Zielke instrumentation was developed to eliminate the disadvantages of Zielke instrumentation in terms of lack of primary stability and a kyphogenic effect. METHODS: All patients underwent an identical anterior surgical technique with the Halm-Zielke instrumentation of the primary curve. The system is composed of a lid-plate, which is fixed to the lateral aspect of the vertebral body with two screws: a sunk screw anteriorly and a ventral derotation spondylodesis (VDS) screw posteriorly. The lid-plate design provides the lowest possible implant profile. The longitudinal components consist of a threaded rod and a solid, fluted rod. Correction is performed with both the threaded and the solid rod. The solid rod allows derotation and correction of the sagittal plane and provides primary stability. RESULTS: Preoperative curves ranged from 35 degrees to 92 degrees Cobb angle. Final correction of the frontal plane averaged 67% within the instrumented levels and 59% for the total primary curve. The apical vertebral rotation of the primary curve was corrected by 52% on average without loss of correction during follow-up. Thoracolumbar kyphosis was present in 11 patients and corrected in all cases from an average of 20 degrees to 2 degrees after surgery and to 8 degrees at follow-up. We observed two cases of implant failure with one resulting in a pseudarthrosis. CONCLUSION: Halm-Zielke instrumentation proved to be a major improvement of the original VDS-Zielke. It eliminates the kyphogenic effect and provides primary stability.

Analysis of vertebral morphology in idiopathic scoliosis with use of magnetic resonance imaging and multiplanar reconstruction.

BACKGROUND: Several studies have provided data on the vertebral morphology of normal spines, but there is a paucity of data on the vertebral morphology in patients with idiopathic scoliosis. METHODS: The morphology of the pedicles and bodies of 307 vertebrae as well as the distance between the pedicles and the dural sac (the epidural space) in twenty-six patients with right-sided thoracic idiopathic scoliosis were analyzed with use of magnetic resonance imaging and multiplanar reconstruction. RESULTS: A distinct vertebral asymmetry was found at the apical region of the thoracic curves, with significantly thinner pedicles on the concave side than on the convex side (p < 0.05). The degree of intravertebral deformity diminished farther away from the apex, with vertebral symmetry restored at the neutral level. In the thoracic spine, the transverse endosteal width of the apical pedicles measured between 2.3 mm and 3.2 mm on the concave side and between 3.9 mm and 4.4 mm on the convex side (p < 0.05). In the lumbar spine, the pedicle width measured between 4.6 mm at the cephalad part of the curve and 7.9 mm at the caudad part of the curve. The chord length and the pedicle length gradually increased from 34 mm and 18 mm, respectively, at the fourth thoracic vertebra to 51 mm and 25 mm, respectively, at the third lumbar vertebra. The transverse pedicle angle measured 15 in the cephalad aspect of the thoracic spine, decreased to 7 at the twelfth thoracic vertebra, and increased again to 16 at the fourth lumbar vertebra. The width of the epidural space was <1 mm at the thoracic apical vertebral levels and averaged 1 mm at the lumbar apical vertebral levels on the concave side, whereas it was between 3 mm and 5 mm on the convex side (p < 0.05). CONCLUSION: Idiopathic scoliosis is associated with distinctive intravertebral deformity, with smaller pedicles on the concave side and a shift of the dural sac toward the concavity.