1.
Pediatr Hematol Oncol
; 23(8): 649-60, 2006 Dec.
Article
in English
| MEDLINE
| ID: mdl-17065141
ABSTRACT
The aim of the study was to evaluate whether IFN-alpha/beta-inducible MxA protein expression in children receiving anticancer treatment can be used as an indicator for virus infections during the febrile episodes. Twenty-six children with mainly hematological malignancies entered the study. Children with laboratory-confirmed virus infections had clearly elevated MxA protein levels compared to their counterparts with bacterial or unknown etiology. MxA protein expression increased moderately following the administration of cytostatic agents, even though these children had no clinical signs of infection.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Bacterial Infections/blood , GTP-Binding Proteins/blood , Lymphocytes/chemistry , Neoplasms/blood , Virus Diseases/blood , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bacterial Infections/complications , Bacterial Infections/diagnosis , Biomarkers , Child , Child, Preschool , Diagnosis, Differential , Disease Susceptibility , Female , Fever/blood , Fever/etiology , Hematologic Neoplasms/blood , Hematologic Neoplasms/complications , Hematologic Neoplasms/drug therapy , Humans , Immunocompromised Host , Interferon-alpha/physiology , Male , Myxovirus Resistance Proteins , Neoplasms/complications , Neoplasms/drug therapy , Predictive Value of Tests , Virus Diseases/complications , Virus Diseases/diagnosis
2.
Methods Mol Biol
; 193: 117-27, 2002.
Article
in English
| MEDLINE
| ID: mdl-12325503
