The effects of alcohol and marijuana co-use patterns on intimate partner aggression perpetration.

Alcohol and marijuana are two of the most widely used substances in the U.S, with rates of alcohol and marijuana co-use increasing in recent years. Despite this increase, little is known about the effects of alcohol and marijuana co-use patterns (e.g., simultaneous, concurrent) on intimate partner aggression (IPA) perpetration. The purpose of the current study was to examine differences in IPA among simultaneous and concurrent alcohol and marijuana use groups and an alcohol-only group. Participants were 496 individuals (57% identifying as a woman) recruited nationally in April 2020 via Qualtrics Research Services who reported being in a current relationship and recently consuming alcohol. Individuals completed an online survey that included demographics, measures of COVID-19 stress, alcohol and marijuana use, and physical and psychological IPA perpetration. Based on survey responses, individuals were categorized as belonging to the alcohol use only group (n = 300), the concurrent alcohol and marijuana use group (n = 129), or the regular simultaneous alcohol and marijuana use group (n = 67). Due to inclusion criteria, there was no marijuana use only group. Individuals with regular simultaneous or concurrent alcohol and marijuana co-use reported more frequent physical and psychological IPA perpetration compared to those who only used alcohol. Neither physical nor psychological IPA perpetration frequency differed between individuals who reported regular simultaneous versus concurrent alcohol and marijuana co-use. Results suggest that alcohol and marijuana co-use in general, and not the specific pattern of use, is associated with an increased likelihood of IPA perpetration.

COVID Stress, socioeconomic deprivation, and intimate partner aggression during the COVID-19 pandemic.

BACKGROUND: Intimate partner aggression (IPA) is a prevalent public health concern that is associated with multiple negative consequences. Rates of IPA in the U.S. have increased since the onset of the Coronavirus Disease 2019 (COVID-19) pandemic, likely due to stress associated with the pandemic. Socioeconomic deprivation is associated with COVID-19 outcomes as well as IPA. However, whether socioeconomic deprivation interacts with COVID-19 stress in predicting IPA remains unclear. METHODS: Using a sample of 510 individuals recruited via Qualtrics Research Services in April 2020, the present study tested whether socioeconomic deprivation moderates the association between COVID-19 stress and IPA perpetration and victimization. Participants completed a questionnaire battery that included measures of COVID-19 stressors and physical and psychological IPA perpetration and victimization. In addition, participants reported their residential zip codes, which were subsequently matched with scores on the Social Deprivation Index, a composite measure of seven demographic variables from the 5-year American Community Survey. RESULTS: Sequential generalized linear models in Mplus Version 8.7 showed that the effects of COVID-19 stress on physical IPA perpetration and psychological IPA victimization can be best understood through its interactive effects with socioeconomic deprivation. Higher COVID-19 stress was associated with higher levels of physical IPA perpetration and psychological IPA victimization when socioeconomic deprivation was low but not when socioeconomic deprivation was high. Importantly, however, overall rates of IPA were higher among individuals with higher socioeconomic deprivation than among individuals with lower socioeconomic deprivation, regardless of the amount of COVID-19 stress they experienced. CONCLUSIONS: The present analyses implicate COVID-19 stress as a critical correlate of IPA and show that the association between this stress and physical IPA perpetration and psychological IPA victimization may be particularly salient among individuals who live in areas of lower socioeconomic deprivation. Furthermore, our results clearly pinpoint the detrimental effects of socioeconomic deprivation more broadly, showing that individuals who live in more deprived areas tend to have high levels of IPA regardless of their level of COVID-19 stress. These findings call for public health policies at the community and societal level that target not only COVID-related stress but also the impacts of socioeconomic inequality.

Zolpidem Profoundly Augments Spared Tonic GABAAR Signaling in Dentate Granule Cells Ipsilateral to Controlled Cortical Impact Brain Injury in Mice.

Type A GABA receptors (GABAARs) are pentameric combinations of protein subunits that give rise to tonic (ITonicGABA) and phasic (i.e., synaptic; ISynapticGABA) forms of inhibitory GABAAR signaling in the central nervous system. Remodeling and regulation of GABAAR protein subunits are implicated in a wide variety of healthy and injury-dependent states, including epilepsy. The present study undertook a detailed analysis of GABAAR signaling using whole-cell patch clamp recordings from mouse dentate granule cells (DGCs) in coronal slices containing dorsal hippocampus at 1-2 or 8-13 weeks after a focal, controlled cortical impact (CCI) or sham brain injury. Zolpidem, a benzodiazepine-like positive modulator of GABAARs, was used to test for changes in GABAAR signaling of DGCs due to its selectivity for α1 subunit-containing GABAARs. Electric charge transfer and statistical percent change were analyzed in order to directly compare tonic and phasic GABAAR signaling and to account for zolpidem's ability to modify multiple parameters of GABAAR kinetics. We observed that baseline ITonicGABA is preserved at both time-points tested in DGCs ipsilateral to injury (Ipsi-DGCs) compared to DGCs contralateral to injury (Contra-DGCs) or after sham injury (Sham-DGCs). Interestingly, application of zolpidem resulted in modulation of ITonicGABA across groups, with Ipsi-DGCs exhibiting the greatest responsiveness to zolpidem. We also report that the combination of CCI and acute application of zolpidem profoundly augments the proportion of GABAAR charge transfer mediated by tonic vs. synaptic currents at both time-points tested, whereas gene expression of GABAAR α1, α2, α3, and γ2 subunits is unchanged at 8-13 weeks post-injury. Overall, this work highlights the shift toward elevated influence of tonic inhibition in Ipsi-DGCs, the impact of zolpidem on all components of inhibitory control of DGCs, and the sustained nature of these changes in inhibitory tone after CCI injury.

Intimate Partner Aggression During the COVID-19 Pandemic: Associations With Stress and Heavy Drinking.

Objective: This study aimed to test empirically whether (1) the local impact of the COVID-19 pandemic was associated with increases in intimate partner aggression (IPA) and heavy drinking, and (2) heavy drinking moderated the association between COVID-19 stress and IPA perpetration. Method: Participants were 510 individuals (approximately 50% who endorsed a sexual or gender minority identity) recruited via Qualtrics Research Services in April 2020, during the height of shelter-in-place (SiP) restrictions across the United States. They completed a questionnaire battery that included measures of COVID-19 stressors, physical and psychological IPA perpetration, and heavy drinking. Results: Rates of physical and psychological IPA perpetration significantly increased after implementation of SiP restrictions which aimed to mitigate the transmission of COVID-19. COVID-19 stress was significantly and positively associated with physical and psychological IPA perpetration; however, COVID-19 stress was positively associated with physical IPA perpetration among non-heavy drinking, but not heavy drinking, participants. Conclusions: Drawn from a large sample of participants of diverse sexual identities, findings tentatively implicate COVID-19 stress as a critical correlate of IPA perpetration and suggest that "low risk" individuals (i.e., non-heavy drinkers) should not be overlooked. These data provide preliminary support for the usefulness of public health polices and individual-level interventions that target stress, heavy drinking, and their antecedents.

Relationship Dissatisfaction, Emotion Regulation, and Physical Intimate Partner Aggression in Heavy-Drinking, Conflict-Prone Couples: A Dyadic Analysis.

Relationship dissatisfaction is a known risk factor for intimate partner aggression (IPA). However, the possible effect of weak emotion regulation skills on this association is unclear, particularly in couples at risk for violence who drink alcohol heavily. This study examined the moderating effect of emotion regulation on the association between relationship dissatisfaction and physical IPA perpetration within a dyadic framework. Participants were 583 heavy drinking couples (N = 1,166) with a recent history of psychological and/or physical IPA recruited from two metropolitan cities in the United States. Multilevel models were used to examine effects within an actor-partner interdependence framework. Gender, Actor dissatisfaction, and Actor and Partner emotion regulation were associated with greater physical IPA perpetration. Actor relationship dissatisfaction predicted significantly greater physical IPA perpetration in Actors characterized by weak versus strong emotion regulation. Furthermore, partner relationship dissatisfaction predicted significantly increased physical IPA perpetration in Actors reporting weak, versus strong, emotion regulation. Gender did not significantly interact with model variables. Utilizing the I3 metatheoretical model of IPA within a dyadic framework, results provide insight into the interactive effects of relationship dissatisfaction and emotion regulation deficits on physical IPA perpetration, particularly in those individuals already at risk for perpetration.

The structure of aggression in conflict-prone couples: Validation of a measure of the Forms and Functions of Intimate Partner Aggression (FFIPA).

Intimate partner aggression (IPA) is a complex construct composed of the means and the motivations by which a person harms his or her intimate partner. Existing measures only assess forms of IPA perpetration while neglecting to measure the motivations for aggressing. The present study sought to fill this lacuna by adapting and validating an existing measure of the forms and functions of adolescent peer aggression to assess IPA perpetration in adults. This new measure-the Forms and Functions of Intimate Partner Aggression (FFIPA)-comprises 4 latent dimensions of IPA (i.e., overt, relational, proactive, and reactive). Participants were 341 heavy-drinking heterosexual couples (N = 682) with a recent history of psychological and/or physical IPA recruited from 2 metropolitan cities in the United States. The FFIPA demonstrated good model fit and internal validity. Unique patterns of convergent and criterion-related validity supported the 4 dimensions of the FFIPA. Results also indicated women perpetrated significantly more overt and relational aggression than men. Findings support the FFIPA as a valid measure of the forms and functions of IPA perpetration. More important, as the only instrument that parses the forms and functions of IPA perpetration, the FFIPA delineates the unique motivations of an aggressive partner separately from the form of his or her aggressive behavior(s). Further replication is needed to generalize this measure to nonconflictual and other types of intimate relationships. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Testosterone modulates spatial recognition memory in male rats.

A growing body of research indicates that testosterone influences spatial cognition in male rats; however, the overwhelming majority of studies have been conducted on tasks motivated by either food deprivation or water escape. The hippocampus-dependent version of the Y-maze task, which characterizes spatial recognition memory, capitalizes on the propensity of rats to gravitate toward novel spatial environments and is not contingent upon either appetite or the stress associated with water escape, two factors also affected by testosterone. Accordingly, the aim of the current study was to examine the effects of orchidectomy and subsequent testosterone treatment on spatial recognition memory. Orchidectomy did not impact spatial recognition memory when the delay between the information and retention trials of the Y-maze task was 24h. Alternatively, on the second Y-maze task, which featured a 48-h delay between trials, orchidectomy reduced, and treatments that produced higher levels of testosterone restored, preference for the arm associated with the novel spatial environment. Importantly, there were no differences in activity levels as a function of orchidectomy or testosterone treatment on either of the two tasks. Consistent with previous findings, orchidectomy attenuated, and testosterone treatment restored, both body weight gain and the relative weight of the androgen-sensitive ischiocavernosus muscle, which confirmed the efficacy of orchidectomy and testosterone treatments on physiological outcomes. Therefore, testosterone influenced spatial cognition on a task that minimized the influence of non-mnemonic factors and took advantage of the innate preference of rodents to seek out novel spatial environments.