1.
Angew Chem Int Ed Engl
; 55(5): 1894-8, 2016 Jan 26.
Article
in English
| MEDLINE
| ID: mdl-26732351
ABSTRACT
Reported is a versatile new oxidative method for the arylation of activated methylene species. Under mild reaction conditions (RT to 40 °C), Cu(OTf)2 mediates the selective coupling of functionalized aryl boron species with a variety of stabilized sp(3) -nucleophiles. Tertiary malonates and amido esters can be employed as substrates to generate quaternary centers. Complementing either traditional cross-coupling or SN Ar protocols, the transformation is chemoselective in the presence of halogen electrophiles, including aryl bromides and iodides. Substrates bearing amide, sulfonyl, and phosphonyl groups, which are not amenable to coupling under mild Hurtley-type conditions, are suitable reaction partners.