Subject(s)
ATPases Associated with Diverse Cellular Activities/genetics , Metalloendopeptidases/genetics , Mutation/genetics , Paraplegia/diagnostic imaging , Paraplegia/genetics , Spastic Paraplegia, Hereditary/diagnostic imaging , Spastic Paraplegia, Hereditary/genetics , Heterozygote , Humans , Male , Middle AgedSubject(s)
Antibodies, Monoclonal, Humanized/adverse effects , Posterior Leukoencephalopathy Syndrome/chemically induced , Anti-Inflammatory Agents/therapeutic use , Antibodies, Monoclonal, Humanized/therapeutic use , Electroencephalography , Female , Humans , Immune Reconstitution Inflammatory Syndrome/complications , Interferon-beta/therapeutic use , JC Virus/immunology , Magnetic Resonance Imaging , Methylprednisolone/therapeutic use , Middle Aged , Multiple Sclerosis, Relapsing-Remitting/complications , Multiple Sclerosis, Relapsing-Remitting/drug therapy , NatalizumabABSTRACT
Seventy-five consecutive patients with clinical symptoms and signs of meralgia paresthetica underwent bilateral somatosensory evoked potential (SEP) studies involving stimulation of skin areas innervated by the lateral and anterior femoral cutaneous nerves of the thighs. The most common abnormality was an absolute lateral femoral cutaneous SEP latency > 40 ms in 35 patients (47%), followed by an absent response in 14 patients (19%), an absolute latency < 40 ms but amplitude reduction > 50% compared with the contralateral response in 8 patients (11%), and an absolute latency < 40 ms but > 5 ms interside latency difference in 5 patients (7%). Anterior femoral cutaneous SEPs were of value in distinguishing meralgia paresthetica from a proximal lumbar radiculopathy in an additional 4 patients and confirming bilateral meralgia paresthetica in 10 patients.
