1.
Org Lett
; 23(10): 4078-4082, 2021 May 21.
Article
in English
| MEDLINE
| ID: mdl-33929868
ABSTRACT
We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.