Subject(s)
Hemangiopericytoma/congenital , Maxillary Neoplasms/congenital , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cisplatin/administration & dosage , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Female , Hemangiopericytoma/drug therapy , Humans , Infant, Newborn , Maxillary Neoplasms/drug therapy , Vincristine/administration & dosageABSTRACT
We report a case of botryoid Wilms' tumor that occupied the renal pelvis and extended into the bladder. A 3-year-old boy was referred to us with a chief complaint of gross hematuria and micturition pain. Computed tomography showed tumor occupying the right renal pelvis and ureter and extending into the bladder. Right radical nephroureterectomy was performed. The resected specimen showed a botryoid sarcoma-like appearance, occupied the right renal pelvis and ureter, and protruded into the bladder. Histologic findings showed typical triphasic Wilms' tumor. Botryoid Wilms' tumor has been reported in only 16 cases in the literature and in only 3 cases extended into the bladder.
Subject(s)
Kidney Neoplasms/pathology , Kidney Pelvis , Urinary Bladder Neoplasms/pathology , Wilms Tumor/pathology , Child, Preschool , Humans , Kidney Neoplasms/surgery , Male , Neoplasm Invasiveness , Urinary Bladder Neoplasms/surgery , Wilms Tumor/surgeryABSTRACT
We describe the clinical course and autopsy findings of a female fetus with hydrops fetalis due to a huge pericardial rhabdomyoma. Fetal echocardiography at 21 weeks gestation demonstrated a huge tumor in the left ventricle. The fetus died of hydrops fetalis due to cardiac dysfunction at 24 weeks gestation. Autopsy demonstrated that the tumor protruded from the epicardial region of the apex into the pericardial cavity and induced a hypoplastic left ventricle and lung. Microscopically, the cardiac tumor showed characteristics of rhabdomyoma. This localization of cardiac rhabdomyoma is rare, but we remain aware of the possibility of an unusual and rapid progression of cardiac rhabdomyoma.
Subject(s)
Fetal Heart/abnormalities , Heart Neoplasms/diagnostic imaging , Lung/abnormalities , Rhabdomyoma/diagnostic imaging , Abnormalities, Multiple/diagnostic imaging , Abnormalities, Multiple/pathology , Adult , Autopsy , Biopsy, Needle , Echocardiography/methods , Female , Fetal Death , Fetal Diseases/diagnostic imaging , Fetal Diseases/pathology , Gestational Age , Heart Neoplasms/embryology , Heart Neoplasms/pathology , Heart Ventricles/abnormalities , Humans , Immunohistochemistry , Maternal Age , Pericardium/pathology , Pregnancy , Rhabdomyoma/embryology , Rhabdomyoma/pathology , Ultrasonography, PrenatalABSTRACT
BACKGROUND: It has been reported that serum KL-6 increases in babies with progressing chronic lung disease (CLD). However, there have been few reports assessing KL-6 in meconium aspiration syndrome (MAS). KL-6 was measured in neonates with respiratory diseases including MAS. METHODS: Thirty-eight neonates with respiratory disease were enrolled in the study. These patients were classified into three groups, 14 patients with respiratory distress syndrome (RDS), 14 with MAS, and 10 with transient tachypnea of the newborn (TTN). The control group consisted of 12 healthy neonates. KL-6 levels were measured 1 day (median) after the birth. In the RDS group, measurement was repeated just prior to 36 weeks' postmenstrual age. RESULTS: The levels of KL-6 were 116 +/- 40 U/mL in the RDS, 281 +/- 138 U/mL in the MAS, and 106 +/- 41 U/mL in the TTN groups. KL-6 levels were significantly higher in the MAS group than in the control group (134 +/- 71 U/mL; P < 0.01). In addition, the levels were significantly higher in those with severe MAS than those with mild MAS (P < 0.05). In patients with RDS, KL-6 increased in patients who developed CLD (P < 0.05), while KL-6 levels did not change in those who did not develop CLD. CONCLUSION: These data confirm the high level of KL-6 in CLD, and suggest that KL-6 is increased in MAS.
