ABSTRACT
With the emergence of new biomaterials and elastography imaging techniques, there is a need for innovative instruments dedicated to viscoelasticity measurements. In this work, we introduce a novel hyper-frequency viscoelastic spectroscopy (HFVS) technique dedicated to characterize soft media subjected to mid-to-very-high frequency stress ranges (or, equivalently, to probe short-to-very-short relaxation times). HFVS, which has been implemented in an analytical instrument performing non-contact measurements in less than 1 s between 10 and 1000 Hz, is a suitable tool to study viscoelasticity for bio-applications. In this context, HFVS has been compared to classical oscillatory rheometry on several classes of soft materials currently encountered in tissue repair, bioengineering and elastography imaging on a frequency range between 10 and 100 Hz. After having demonstrated the good correspondence between HFVS and rheometry, this study has been completed by exploring the sensitivity of HFVS to physicochemically induced variations of viscoelasticity. HFVS opens promising perspectives in the challenging field of biomaterial science and for viscoelasticity-based quality control of materials.
Subject(s)
Elasticity , Materials Testing/instrumentation , Spectrum Analysis , Agar/chemistry , Bioengineering , Gelatin/chemistry , Rheology , Stress, Mechanical , ViscosityABSTRACT
Rheological properties of concentrated chitosan aqueous solutions and gels in the presence of different organic and inorganic acids were investigated. Viscosities of the solutions increased with polymer concentration and degree of ionization. Strong gels were obtained at pH around 2 with oxalic, phosphoric and sulfuric acids. Gelation was favored by simple and short chain length acids and was governed by ionic interactions. The gels could be distinguished from solutions by the frequency independence of their dynamic moduli and their high apparent activation energy for flow.