ABSTRACT
Biochemical estimation of alkaline phosphatase (AP) in livers of mice experimentally infected with the Egyptian strain of S. mansoni before and after oltipraz treatment was carried out. The drug was given in a single oral dose of 500 mg/kg body weight. The results revealed that the drug led to gradual reduction in the AP mean level after 20 and 30 days from treatment. This was then followed by rise in the enzyme mean level, after 60 days. The drug also caused significant reduction in the AP mean level in livers of the drug control group of mice after 5 and 20 days from oltipraz administration in comparison normal uninfected controls. These findings might be attributed to a hepatocytotoxic effect of the drug.
Subject(s)
Alkaline Phosphatase/analysis , Liver/enzymology , Pyrazines/therapeutic use , Schistosomiasis mansoni/drug therapy , Schistosomicides/therapeutic use , Animals , Male , Mice , Pyrazines/adverse effects , Schistosomicides/adverse effects , Thiones , ThiophenesABSTRACT
Extraction of alkaline phosphatase (AP) from the tissues of small intestines of mice experimentally infected with the Egyptian strain of S. mansoni before and after oltipraz treatment was carried out. The drug was given in a single oral dose of 500 mg/kg body weight. The results obtained revealed that the drug led to significant reduction in the AP mean level after 30 and 60 days from therapy in comparison to the infected untreated controls. Oltipraz also caused significant reduction in the intestinal AP mean level of the drug control group of mice after 5 and 20 days from drug administration in comparison to normal controls, which might be attributed to the toxic effect of the drug on the intestinal cells.
Subject(s)
Alkaline Phosphatase/metabolism , Intestines/drug effects , Pyrazines/therapeutic use , Schistosomiasis mansoni/drug therapy , Schistosomicides/therapeutic use , Animals , Intestines/enzymology , Male , Mice , Pyrazines/adverse effects , Schistosomiasis mansoni/enzymology , Schistosomicides/adverse effects , Thiones , ThiophenesSubject(s)
Cattle Diseases/enzymology , Mite Infestations/veterinary , Sheep Diseases/enzymology , Tick Infestations/veterinary , Alanine Transaminase/blood , Alkaline Phosphatase/blood , Animals , Aspartate Aminotransferases/blood , Blood Proteins/metabolism , Cattle , Female , Male , Mite Infestations/enzymology , Sheep , Tick Infestations/enzymologyABSTRACT
Seventy boys, aged 6-13 years were subjected to periodic oral vitamin A program. Non-parasitized boys (n = 63) responded to the oral treatment with significant increase in plasma retinol level, even five weeks after the end of oral treatment. On the other hand, boys infested with parasites, none of whom had originally acceptable plasma-retinol level, did not respond significantly to the oral treatment. Vitamin A was found also to have an effect on growth, and there was highly significant correlation between retinol level and percentile weight for age.