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1.
Ann Vasc Surg ; 86: 320-327, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35483617

ABSTRACT

BACKGROUND: The objective of this population-based study was to analyze short- and long-term major adverse cardiovascular events (MACE) after endovascular repair of ruptured or nonruptured thoracic (TAA) and abdominal aortic aneurysms (AAA). METHODS: Nationwide retrospective registry study including all patients who underwent endovascular repair (thoracic endovascular aortic repair, TEVAR; abdominal endovascular aneurysm repair, EVAR) for nonruptured/intact (iAAA/iTAA) or ruptured (rAAA/rTAA) abdominal or thoracic aneurysms between 2000 and 2018. The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction (MACE). RESULTS: There were 8,641 patients with TAA and AAA; 634 TEVAR procedures [iTAA 488; rTAA 146], and 8007 EVAR procedures [iAAA 7071; rAAA 936] were performed. MACE incidence at 90-day after TEVAR for iTAA was 10.2% and for rTAA 26.7% [HR 3.02, 95% CI 1.99-4.6]; MACE at 90-day after EVAR for iAAA was 3.7% and for rAAA 26.9% [HR 8.5, 95% CI: 7.16-10.11]. There was a higher cumulative incidence of MACE at 90-day after TEVAR for iTAA compared to EVAR for iAAA [HR 2.82, 95% CI 2.09-3.82] but no difference between the procedures after ruptured aneurysm repair. The median follow-up time was 3.28 years [IQR 1.31-5.94]. There was no long-term difference in MACE between EVAR and TEVAR after ruptured [90 days-5 years: HR 1.14, 95% CI 0.76-1.71; 5-10 years: HR 0.78, 95% CI 0.31-1.96] or intact [90 days-5 years: HR 1.19, 95% CI 0.97-1.46; 5-10 years: HR 0.82, 95% CI 0.56-1.21] aneurysm repair. Female gender had higher long-term incidence of MACE after intact [HR 1.14, 95% CI 1.03-1.27] and ruptured [HR 1.36, 95% CI 1.12-1.65] endovascular aortic aneurysm treatment. After intact aneurysms repair; age [HR 1.05, 95% CI 1.04-1.05], history of angina pectoris [HR 1.19, 95% CI 1.08-1.32], heart failure [HR 1.90, 95% CI 1.69-2.13], and stroke [HR 1.33, 95% CI 1.15-1.53] were associated with MACE. CONCLUSIONS: This nationwide cohort study still demonstrated a high risk of early and late cardiovascular events after endovascular aortic repair. Comprehensive strategies for postoperative cardiovascular disease prevention may be needed here.


Subject(s)
Aortic Aneurysm, Abdominal , Aortic Rupture , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Stroke , Humans , Female , Aortic Aneurysm, Abdominal/diagnostic imaging , Aortic Aneurysm, Abdominal/surgery , Aortic Aneurysm, Abdominal/complications , Aortic Rupture/diagnostic imaging , Aortic Rupture/surgery , Aortic Rupture/complications , Blood Vessel Prosthesis Implantation/adverse effects , Endovascular Procedures/adverse effects , Retrospective Studies , Cohort Studies , Risk Factors , Treatment Outcome , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Postoperative Complications/surgery , Stroke/etiology , Stroke/complications
2.
Ann Vasc Surg ; 86: 313-319, 2022 10.
Article in English | MEDLINE | ID: mdl-35248744

ABSTRACT

BACKGROUND: Ruptured abdominal aortic aneurysm (rAAA) repair is still associated with high mortality. The aim of this population-based study was to analyze the time distribution of mortality and short-term mortality trends after rAAA repair. METHODS: This was a nationwide retrospective registry study including all patients (n = 3,927) who underwent endovascular (EVAR) (n = 935) or open surgical repair (OSR) (n = 2,992) for rAAA between 2000 and 2018. The National Patient Register was used as a source to extract patient and medical data. The register was cross-linked with the national all-cause mortality registry. The postoperative time of death was divided into <48 hours, 2 to 5 days, 6 to 10 days, 11 to 20 days, 21 to 30 days, and 31 to 90 days during the year intervals 2000-2004, 2005-2009, 2010-2014, and 2015-2018, respectively. The proportion of patients who died within each postoperative time interval was calculated. RESULTS: The overall median age was 75.0 years (interquartile range [IQR] 69.0-80.0) and females were 19.6% (n = 769). The EVAR cohort was older (77 vs. 65 years; P < 0.001) and had significantly more cardiovascular risk factors and a history of malignancy. The overall postoperative 90-day mortality was 33.2%, EVAR 25.7%, and OSR 35.5%. There was an overall improvement in 90-day mortality over time (odds ratio [OR] 0.70; 95% confidence interval [CI] 0.57-0.87; P = 0.001) but not separately for EVAR or OSR. Analyzing all postoperative mortalities within 90 days, 43.4% of deaths occurred within 48 hours followed by 16.3% in 2-5 days. The distribution of mortality proportions in each time interval after OSR was 15.4% in < 48 hours, 7.3% in 2-5 days, 4.4% in 6-10 days, 8.6% in 11-30 days, and 6.0% in 31-90 days and after EVAR 11.1% < 48 hours, 3.6% 2-5 days, 3.1% 6-10 days, 4.6% 11-30 days, and 6% 31-90 days. The overall mortality proportions for patients who died <48 hours after aortic repair had decreased over time (P = 0.024). A logistic regression analysis found the following risk factors associated with mortality <48 hours after rAAA, open repair (OR 1.48; 95% CI 1.17-1.89; P = 0.001), female gender (OR 1.41; 95% CI 1.14-1.75; P = 0.002), and history of heart failure (OR 1.63; 95% CI 1.19-2.22; P = 0.002) or angina pectoris (OR 1.37; 95% CI 1.03-1.81; P = 0.03). The recent operative year interval, 2015-2018, was associated with a lower risk for mortality <48 hours (OR 0.72; 95% 0.53-0.98; P = 0.04) and <90-days (OR 0.63; 95% CI 0.49-0.80; P < 0.001). CONCLUSIONS: Overall mortality after rAAA repair had decreased but early deaths remained a significant challenge. The mortality was highest within two days of surgery but the proportion of patients who died <48 hours after aortic repair had decreased in recent years. Open repair, female gender, and cardiovascular comorbidities were associated with mortality within 48 hours after surgery. More focused research in the early postoperative phase after rAAA is warranted.


Subject(s)
Aortic Aneurysm, Abdominal , Aortic Rupture , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Humans , Female , Aged , Aortic Aneurysm, Abdominal/diagnostic imaging , Aortic Aneurysm, Abdominal/surgery , Aortic Aneurysm, Abdominal/complications , Blood Vessel Prosthesis Implantation/adverse effects , Endovascular Procedures/adverse effects , Retrospective Studies , Treatment Outcome , Postoperative Complications/etiology , Aortic Rupture/diagnostic imaging , Aortic Rupture/surgery , Aortic Rupture/etiology , Risk Factors
3.
J Vasc Surg ; 74(2): 547-555, 2021 08.
Article in English | MEDLINE | ID: mdl-33600932

ABSTRACT

OBJECTIVE: To evaluate short term outcomes related to the use of the Zenith TX2 Dissection Endovascular Graft (ZDEG) and the Zenith Dissection Bare stent (ZDES) for the treatment of Stanford type B aortic dissections. METHODS: This retrospective multicenter case cohort study collated data from 10 European institutions for patients with both complicated and uncomplicated type B aortic dissection treated with ZDEG and ZDES between 2011 and 2018. The primary end point was mortality at 30 and 90 days. Secondary end points included complications related to TEVAR, such as, type Ia endoleak, stroke, paraparesis, paraplegia, and retrograde type A dissection (RTAD). Statistical analysis was carried out using the t test, or one-way analysis of variance and the χ2 or Fisher exact tests. RESULTS: We treated 120 patients (87 male; mean age, 62.7 ± 12.2years) either in the acute 76 (63.3%), subacute 16 (13.3%), or chronic 28 (23.3%) phase. Seven patients (5.8%) died within 30 days after the index procedure and two (1.7%) between 30 and 90 days. There was one instance of postoperative RTAD in a patient treated for rupture. Stroke and paraplegia occurred in three (2.5%) and five (4.2%), patients, respectively. Eight patients (6.7%) had a type Ia endoleak in the perioperative period. There were no instances of paraplegia, no permanent dialysis, and no requirement for adjunctive superior mesenteric or celiac artery stenting in the 33 patients (27.5%) who were treated by concurrent placement of ZDES distal to the ZDEG. The length and distal oversizing of ZDEG components used was less in this group. CONCLUSIONS: The present series demonstrates a low (<1%) RTAD rate and favorable morbidity and mortality. The lower rate of paraplegia, dialysis, and visceral artery stenting in the cohort that had adjunctive use of ZDES is compelling and merits further assessment.


Subject(s)
Aortic Aneurysm, Thoracic/surgery , Aortic Dissection/surgery , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis , Endovascular Procedures/instrumentation , Stents , Aged , Aortic Dissection/diagnostic imaging , Aortic Dissection/mortality , Aortic Aneurysm, Thoracic/diagnostic imaging , Aortic Aneurysm, Thoracic/mortality , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/mortality , Endovascular Procedures/adverse effects , Endovascular Procedures/mortality , Europe , Female , Humans , Male , Middle Aged , Postoperative Complications/mortality , Prosthesis Design , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome
4.
Eur J Vasc Endovasc Surg ; 57(6): 788-794, 2019 06.
Article in English | MEDLINE | ID: mdl-30910493

ABSTRACT

OBJECTIVE: The purpose of this multicentre study was to analyse the outcome of thoracic endovascular aortic repair (TEVAR) in patients with ruptured descending thoracic aortic aneurysm (rDTAA). METHODS: This is a nationwide retrospective study including all patients who underwent TEVAR for rDTAA at six major vascular university centres in Sweden between January 2000 and December 2015. Outcome measures were analysed using Kaplan-Meier estimator and multivariable Cox regression. RESULTS: There were 140 patients (age [mean ± SD] 74.1 ± 8.8 years; 56% men; aneurysm size 64.8 ± 19 mm), with rDTAA. In 53 patients (37.9%), the left subclavian artery was covered, and in 25 patients (17.9%) arch vessel revascularisation was performed. In total, 61/136 patients (45%) had a major complication within 30 days post TEVAR. Stroke (n = 20; 14.7%) was the most common complication, followed by paraplegia (n = 13; 9.6%) and major bleeding (n = 13; 9.6%). TEVAR related complications during follow up included endoleaks 22.1% (30/136; 14 type 1a, six type 1b, 10 not defined). In total, re-interventions (n = 31) were required in 27/137 (19.7%) patients. The median follow up time was 17.0 months (range 0-132 months). The Kaplan-Meier estimated survival was 80.0% at one month, 71.7% at three months, 65.3% at one year, 45.9% at three years, and 31.9% at five years. Age (HR 1.03; 95% CI 1.00-1.07; p = .046), history of stroke (HR 2.35; 95% CI 1.19-4.63; p = .014), previous aortic surgery (HR 2.11; 95% CI 1.15-3.87; p = .016) as well as post-operative major bleeding (HR 4.40; 95% CI 2.20-8.81; p = .001), stroke (HR 2.63; 95% CI 1.37-5.03; p = .004), and renal failure (HR 8.25; 95% CI 2.69-25.35; p = .001) were all associated with mortality. CONCLUSIONS: This nationwide multicentre study of patients with rDTAA undergoing TEVAR showed acceptable short- but poor long-term survival. Adequate proximal and distal aortic sealing zones are important for technical success. High risk patients and post-operative complications need to be further addressed in an effort to improve outcome.


Subject(s)
Aortic Aneurysm, Thoracic/surgery , Aortic Rupture/surgery , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Adult , Aged , Aged, 80 and over , Aortic Aneurysm, Thoracic/diagnostic imaging , Aortic Aneurysm, Thoracic/mortality , Aortic Rupture/diagnostic imaging , Aortic Rupture/mortality , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/mortality , Endovascular Procedures/adverse effects , Endovascular Procedures/mortality , Female , Humans , Male , Middle Aged , Postoperative Complications/etiology , Retrospective Studies , Risk Assessment , Risk Factors , Sweden , Time Factors , Treatment Outcome
5.
Innovations (Phila) ; 8(3): 245-7, 2013.
Article in English | MEDLINE | ID: mdl-23989822

ABSTRACT

We describe a technique to gain an additional endovascular access in acute situations in which a large-bore introducer is already inserted or in situations in which multiple accesses are impaired because of other reasons. Using an existing percutaneous femoral artery access, a second guide wire is inserted into the introducer, which is later withdrawn and applied onto one of the two guide wires. A double-wire access is then achieved. This access can be used, for example, for angiography or embolization catheters. This method might be useful in situations in which a quick and unplanned extra access is needed. It is, for example, applicable in hemodynamically unstable patients in whom percutaneous access can be difficult to obtain or in aortic endovascular procedures when an unplanned access is needed to insert an additional catheter for angiography and embolization.


Subject(s)
Endovascular Procedures/methods , Blood Vessels , Endovascular Procedures/instrumentation , Humans , Punctures/instrumentation , Punctures/methods , Vascular Access Devices
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