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Chem Pharm Bull (Tokyo) ; 54(2): 278-9, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16462085

ABSTRACT

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.


Subject(s)
Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Antitubercular Agents/chemistry , Antitubercular Agents/pharmacology , Fabaceae/chemistry , Insecticides/chemistry , Insecticides/pharmacology , Animals , Biological Assay , Culex , Drug Evaluation, Preclinical , Larva/drug effects , Magnetic Resonance Spectroscopy , Mass Spectrometry , Microbial Sensitivity Tests , Mycobacterium tuberculosis/drug effects , Peru , Trichophyton/drug effects
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