FACTORS ASSOCIATED WITH ANEMIA IN WOMEN OF REPRODUCTIVE AGE IN IRAQI FEMALES SAMPLE.

OBJECTIVE: The aim of this study: to determine the different causes of anemia among anemic women of reproductive age and to define associations between severity of anemia with different patient characteristics. PATIENTS AND METHODS: Materials and methods: This is a community based cross-sectional study that was conducted between October and December 2020 among a sample of anemic women at reproductive age between (14-49 years), who attended the private clinic in Baghdad city. The sample consisted of 120 participants (100 non-pregnant women and 20 pregnant women). Socio-demographic characteristic data were collected including occupation, socioeconomic status, marital status, family history of anemia, history of Pica, and number of pregnancies. Questions related to the causes of anemia: Dietary habits, menstrual cycle duration and profusion, current pregnancy, Gastrointestinal blood loss (any form), any chronic illness (like connective tissue disease , inflammatory bowel diseases, hypothyroidism ,chronic infection) and auto-immune hemolytic disease. Baseline hematological parameter were included, hemoglobin level, Mean corpuscular hemoglobin (MCV), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), Serum ferritin and ESR. RESULTS: Results: A total of 120 women, the mean hemoglobin level was 9.43 g/dL. Iron deficiency anemia was the commonest type of anemia in 67.20% followed by inherited hemolytic anemia in 20%; auto-immune hemolytic anemia found in 5.6%, while megaloblastic anemia and anemia of chronic diseases forming 5.6% and 4% respectively. There is a significant association between severity of iron deficiency anemia and different age groups in addition to the amount of weekly consumption of red meat. CONCLUSION: Conclusions: Iron deficiency anemia is the most common form of anemia found in this sample followed by inherited cause of anemia. Many individual and socioeconomic factors were associated with the development of anemia in women of reproductive age. Giving special attention and important diagnosis of anemia for those groups of women especially during reproductive age who had a higher prevalence of anemia.

OUTCOME OF ALLOGENEIC BONE MARROW TRANSPLANT FOR IRAQI PATIENTS WITH ACUTE MYELOID LEUKEMIA.

OBJECTIVE: The aim: To assess the outcome of allogeneic transplant regarding the overall Survival (OS) and main predictors can effect the survival of such patients. PATIENTS AND METHODS: Materials and methods: The records of seventy-nine Iraqi patients diagnosed with non-promyelocytic AML, who underwent allogeneic bone marrow transplantation outside of Iraq between 2012 and 2019, had been reviewed. The information had been collected from the data available in Bone Marrow Transplant Centre in Baghdad Medical City. Overall survival had been calculated by Kaplan-Meier Method. Patients included in the study are those who were diagnosed with acute myeloid leukemia according to French American British classes with the exclusion of acute promyelocytic leukemia (M3), who were allotransplanted for being diagnosed with high risk cytogenetic, refractory to chemotherapeutic regimen, relapsed after achieving complete remission, secondary to transformation from other myeloid malignancies or remaining with positive measurable residual disease after treatment. RESULTS: Results: The overall survival for 1 year, 2 years and 3 years were 63.20%, 55.09% and 46.58% respectively. The pre-transplanted factors found, no significant difference in overall survival regarding age, gender, extra medullary involvement. The transplant related criteria like stem cell source, presence of infection and type of conditioning regimen and incidence of any post-transplant complications do not predict overall survival apart from chronic graft versus host disease. Chronic GVHD were found to be significantly affecting overall survival. CONCLUSION: Conclusions: The most common cause of death was disease relapse. Iraqi AML patients who were treated with allogeneic bone marrow transplant had shown to have encouraging overall survival.