ABSTRACT
The FKBP protein family has prolyl isomerase activity and is related in function to cyclophilins. FKBPs are known to be involved in many biological processes including hormone signaling, plant growth, and stress responses through a chaperone or an isomerization of proline residues during protein folding. The availability of complete peach genome sequences allowed the identification of 21 FKBP genes by HMMER and BLAST analyses. Scaffold locations of these FKBP genes in the peach genome were determined and the protein domain and motif organization of peach FKBPs were analyzed. The phylogenetic relationships between peach FKBPs were also assessed. The expression profiles of peach FKBP gene results revealed that most peach FKBPs were expressed in all tissues, while a few peach FKBPs were specifically expressed in some of the tissues. This data could contribute to better understanding of the complex regulation of the peach FKBP gene family, and also provide valuable information for further research in peach functional genomics.
Subject(s)
Genome, Plant/genetics , Plant Proteins/genetics , Prunus/genetics , Tacrolimus Binding Proteins/genetics , Amino Acid Sequence , Genome-Wide Association Study/methods , Molecular Sequence Data , Phylogeny , Plant Proteins/metabolism , Protein Structure, Tertiary/genetics , Prunus/metabolism , Sequence Alignment , Tacrolimus/metabolism , Transcriptome/geneticsABSTRACT
Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. Recently, single nucleotide polymorphisms (SNPs) in the region of B lymphoid tyrosine kinase (BLK) have been shown to be associated with SLE in Caucasian population. In this paper, we genotyped SNP rs2248932 in 1,396 SLE patients of Chinese Han and 4,362 ethnically matched control subjects by using the Sequenom MassArray system. We confirmed that SNP rs2248932 in BLK gene was significantly associated with SLE (P = 1.41 x 10(-8) for the allele frequency, Odds ratio [OR] = 0.74, 95% confidence interval (CI): 0.66-0.82).The association of BLK in Chinese SLE patients was consistent with a dominant model (P = 8.88 x 10(-9), OR = 0.69, 95% CI: 0.61-0.79). In contrast to the Caucasian, this risk allele was the major allele in the Chinese Han; the risk allele frequency was higher in Chinese Han than in Caucasian. We did not find the association between this SNP and any subphenotype of SLE. The SNP rs2248932 was correlated to the expression of BLK mRNA. We conclude that the association of the BLK region with SLE was replicated in Chinese Han population living in mainland.
Subject(s)
Asian People/genetics , Genetic Predisposition to Disease , Lupus Erythematosus, Systemic/genetics , Polymorphism, Single Nucleotide , src-Family Kinases/genetics , Adult , B-Lymphocytes/enzymology , China , Female , Gene Frequency , Genome-Wide Association Study , Genotype , Humans , Male , Polymerase Chain Reaction , Risk FactorsABSTRACT
In this paper, we present an effective technique to enhance stopband bandwidth for a bandpass filter by using an asymmetric, cross-shape defected ground structure (CSDGS). A single CSDGS can provide a higher attenuation rate near passband and broader stopband bandwidth. Moreover, with the asymmetric CSDGS, two different resonant frequencies can be excited and controlled independently, resulting in synthesizing a passband. The synthesized bandpass filter can be modeled by parallel LC resonant circuits in connection with T-networks. The bandwidth and insertion loss of this bandpass filter at 4.2 GHz is 28.6% and -1.44 dB, respectively, and 20 dB rejection in the stopband is up to four times the central frequency. All the synthesized bandpass filters have been measured and are in good agreement with simulated results.
ABSTRACT
A novel microstrip bandpass filter with three types of rectangular, photonic bandgap (PBG) loops on a middle layer was designed and demonstrated using a full-wave electromagnetic (EM) simulator, with the predicted results verified by experiment. This investigation presents the configurations of conventional parallel-coupled 2 GHz filters with and without a PBG. The middle-layer of PBG loops adds an extra stopband-rejection mode to filter stopband; and it provides attenuation in excess of 25 dB at the second, third, and fourth harmonics, thus demonstrating that superior stopband characteristics at high frequency can be obtained using the proposed PBG loops in microwave filters.
