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A novel dual near-infrared fluorescent probe for bioimaging and visualization of viscosity in acute alcoholic liver injury.
Wang, Ruonan; Zhou, Xucong; Li, Bingxue; Ding, Ru; Han, Jingqian; Wang, Ying; Meng, Aixia; Zhou, Jin.
Chem Commun (Camb) ; 60(45): 5804-5807, 2024 May 30.
Article in English | MEDLINE | ID: mdl-38712712

ABSTRACT

A dual NIR fluorescent probe Cy-ND is developed for viscosity sensing with λex/em = 766/806 nm, making it apt for biological analysis, whose response is validated through DFT and TDDFT computations. Cy-ND successfully detected viscosity changes amidst acute alcohol-induced liver injury and liver ischemia-reperfusion injury.


Subject(s)
Fluorescent Dyes , Fluorescent Dyes/chemistry , Fluorescent Dyes/chemical synthesis , Viscosity , Animals , Optical Imaging , Humans , Mice , Density Functional Theory , Liver/diagnostic imaging , Liver Diseases, Alcoholic/diagnostic imaging , Reperfusion Injury/diagnostic imaging , Carbocyanines/chemistry
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