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1.
Nurse Educ Pract ; 77: 103996, 2024 May.
Article in English | MEDLINE | ID: mdl-38763114

ABSTRACT

AIM: To explore the learning experiences and career development expectations of nursing master's degree students. BACKGROUND: With increasing demands for improved quality of life, there is a growing need for nursing graduate programs in clinical care. However, the existing training programs for nursing master's students in China require improvement. It is essential to analyze students' learning experiences, perceptions of the current status of nursing and expectations of the nursing profession to enhance and develop university training programs. DESIGN: A descriptive qualitative study employing semi-structured interviews. METHOD: Semi-structured interviews were conducted with 14 nursing master's degree students. The data obtained were analyzed using Colaizzi's seven-step phenomenological analysis method. The study adhered to the consolidated criteria for reporting qualitative research (COREQ). RESULTS: Three main themes emerged from the analysis-Theme 1: Career expectations, encompassing motivations for pursuing the nursing master's program and career aspirations; Theme 2: Study experiences, including nursing professional ability, nursing management ability, self-awareness ability and moral literacy; Theme 3: Occupational dilemmas, encompassing the current challenges and coping strategies. CONCLUSION: The learning experiences of nursing master's students in universities are closely linked to their training programs. A disparity exists between students' career expectations and the actual employment landscape for nursing master's degree students.


Subject(s)
Education, Nursing, Graduate , Qualitative Research , Students, Nursing , Humans , Students, Nursing/psychology , China , Female , Male , Adult , Interviews as Topic , Career Choice , Motivation , Learning , East Asian People
2.
Spectrochim Acta A Mol Biomol Spectrosc ; 317: 124423, 2024 Sep 05.
Article in English | MEDLINE | ID: mdl-38759395

ABSTRACT

A simple and sensitive device for the detection of nitrite and nitrate in environmental waters was developed based on visible light gas-phase molecular absorption spectrometry. By integrating a detection cell (DC), semiconductor refrigeration temperature-controlling system (SRTCY), and nitrite reactor into a sequential injection analysis system, trace levels of nitrite and nitrate in complex matrices were successfully measured. A low energy-consuming light-emitting diode (violet, 400-405 nm) was coupled with a visible light-to-voltage converter (TSL257) to measure the gas-phase molecular absorption. To reduce the interference of water vapor, an SRTCY was used to condense the water vapor on-line before the gas-phase analyte entered the DC. The DC was radiatively heated by the SRTCY to avoid water vapor condensation in the light path. As a result, the obtained baseline noise reduced 3.75 times than that of without SRTCY. Under the optimized conditions, the device achieved limits of detection (3σ/k) of 0.055 and 0.36 mmol/L (0.77 and 5.04 mg N/L) for nitrite and nitrate, respectively, and the linear calibration ranges were 0.1-15 mmol/L (R2 = 0.9946) and 1-10 mmol/L (R2 = 0.9995), respectively. Precisions of 5.2 % and 9.0 % were achieved for ten successive determinations of 0.3 mmol/L nitrite and 1.0 mmol/L nitrate, and the analytical times for nitrite and nitrate determination were 5 and 13 min, respectively. This method was validated against standard methods and recovery tests, and it was applied to the measurement of nitrite and nitrate in environmental waters. Moreover, a device was designed to enable the field measurement of nitrite and nitrate in complex matrices.

3.
ACS Pharmacol Transl Sci ; 7(4): 933-950, 2024 Apr 12.
Article in English | MEDLINE | ID: mdl-38633590

ABSTRACT

Cystic fibrosis (CF) is a genetic disorder arising from variations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leading to multiple organ system defects. CFTR tool compounds are molecules that can modify the activity of the CFTR channel. Especially, patients that are currently not able to benefit from approved CFTR modulators, such as patients with rare CFTR variants, benefit from further research in discovering novel tools to modulate CFTR. This Review explores the development and classification of CFTR tool compounds, including CFTR blockers (CFTRinh-172, GlyH-101), potentiators (VRT-532, Genistein), correctors (VRT-325, Corr-4a), and other approved and unapproved modulators, with detailed descriptions and discussions for each compound. The challenges and future directions in targeting rare variants and optimizing drug delivery, and the potential synergistic effects in combination therapies are outlined. CFTR modulation holds promise not only for CF treatment but also for generating CF models that contribute to CF research and potentially treating other diseases such as secretory diarrhea. Therefore, continued research on CFTR tool compounds is critical.

4.
Environ Sci Technol ; 58(8): 3966-3973, 2024 Feb 27.
Article in English | MEDLINE | ID: mdl-38353415

ABSTRACT

The occurrence of chlorinated derivatives of bisphenol S (Clx-BPS) and BPS was investigated in nine types of paper products (n = 125), including thermal paper, corrugated boxes, mail envelopes, newspapers, flyers, magazines, food contact paper, household paper, and business cards. BPS was found in all paper product samples, while Clx-BPS were mainly found in thermal paper (from below the limit of detection (

Subject(s)
Benzhydryl Compounds , Paper , Humans , Food , Commerce
5.
Clin Res Hepatol Gastroenterol ; 48(2): 102287, 2024 02.
Article in English | MEDLINE | ID: mdl-38253255

ABSTRACT

BACKGROUND: Early onset gastric cancer (EOGC) has been on the rise in recent years and differs slightly in pathology from traditional gastric cancer (TGC). Somatic mutations have an essential role in the development of gastric cancer. We aimed to investigate these two types of gastric cancers at the level of somatic mutations and to further understanding of gastric cancer development. METHODS: Somatic mutation, copy number variation (CNV), and clinical information were obtained from TCGA and UCSC Xena. Samples were divided into EOGC (< 50 years old, N = 28) and TGC (≥ 50 years old, N = 395) groups based on age. R packages "maftools" and "sigminer" were used to identify mutation signatures, while CNV information was processed using GISTIC2.0. RESULTS: CDH1(21 %, P = 0.030) and ARID1A (28 %, P = 0.014) were more common in EOGC and TGC, respectively. The mutation frequency of ARID1A increased with age, while the opposite was true for CDH1. Sex, Lauren classifications, tumor mutation burden levels, mutation status of TP53, MUC6, NIPBL, KRAS, and copy number variation of the WOOX can affect the activity of the mutant signature. CONCLUSIONS: Early-onset gastric cancer and traditional gastric cancer have distinct somatic mutation signatures, each with its own relatively specific high-frequency mutated genes, and the gene's mutation frequency correlates with age. Several clinical factors and genetic status affect the activity of some mutational features in gastric cancer in both groups.


Subject(s)
Stomach Neoplasms , Humans , Middle Aged , Stomach Neoplasms/genetics , Stomach Neoplasms/pathology , DNA Copy Number Variations , Genetic Predisposition to Disease , Mutation , Cell Cycle Proteins/genetics
6.
Public Health ; 226: 182-189, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38071951

ABSTRACT

OBJECTIVES: This study aimed to assess the global temporal trends of stomach cancer attributable to smoking from 1990 to 2019 and to predict the global burden by 2044. STUDY DESIGN: This was a comprehensive analysis based on data provided by the Global Burden of Disease Study 2019. METHODS: Based on the Global Burden of Disease Study 2019, mortality, disability-adjusted life years (DALYs), and corresponding age-standardised rates of stomach cancer attributable to smoking by sociodemographic index (SDI), region, country, sex, and age were used to assess temporal trends from 1990 to 2019 by calculating the average annual percentage change (AAPC). In addition, the global burden of stomach cancer attributable to smoking up to 2044 was predicted using age-period-cohort models. RESULTS: Globally, in 2019, 17.96% of stomach cancer deaths (1.72 million) and 17.15% of stomach cancer DALYs (38.13 million) were attributable to smoking, representing an increase compared to 1990; however, smoking-attributable age-standardised rates of mortality (ASMRs) and DALYs (ASDRs) significantly declined to 2.12/100,000 and 45.82/100,000 in 2019, respectively. While stomach cancer ASMR and ASDR attributable to smoking decreased in all regions and in most countries, they increased by >10% in some countries. A positive correlation was found between SDI and age-standardised rates (rASMR = 0.28, P < 0.01; rASDR = 0.29, P < 0.01). By 2044, although global age-standardised rates for smoking-attributable stomach cancer are predicted to decline, deaths and DALYs are estimated to increase to 2.22 million and 42.14 million, respectively. CONCLUSIONS: Stomach cancer deaths and DALYs attributable to smoking have increased over the past 30 years and will continue to increase. Consequently, targeted prevention efforts and tobacco-control strategies need to be further developed and improved.


Subject(s)
Stomach Neoplasms , Humans , Stomach Neoplasms/epidemiology , Quality-Adjusted Life Years , Global Burden of Disease , Smoking/adverse effects , Smoking/epidemiology , Global Health
7.
Pharmaceutics ; 15(5)2023 May 13.
Article in English | MEDLINE | ID: mdl-37242730

ABSTRACT

Pulmonary drug delivery has long been used for local and systemic administration of different medications used in acute and chronic respiratory diseases. Certain lung diseases, such as cystic fibrosis, rely heavily on chronic treatments, including targeted lung delivery. Pulmonary drug delivery possesses various physiological advantages compared to other delivery methods and is also convenient for the patient to use. However, the formulation of dry powder for pulmonary delivery proves challenging due to aerodynamic restrictions and the lower tolerance of the lung. The aim of this review is to provide an overview of the respiratory tract structure in patients with cystic fibrosis, including during acute and chronic lung infections and exacerbations. Furthermore, this review discusses the advantages of targeted lung delivery, including the physicochemical properties of dry powder and factors affecting clinical efficacy. Current inhalable drug treatments and drugs currently under development will also be discussed.

8.
NPJ Parkinsons Dis ; 9(1): 57, 2023 Apr 10.
Article in English | MEDLINE | ID: mdl-37037843

ABSTRACT

Changes of brain network dynamics reveal variations in macroscopic neural activity patterns in behavioral and cognitive aspects. Quantification and application of changed dynamics in brain functional connectivity networks may contribute to a better understanding of brain diseases, and ultimately provide better prognostic indicators or auxiliary diagnostic tools. At present, most studies are focused on the properties of brain functional connectivity network constructed by sliding window method. However, few studies have explored evidence-based brain network construction algorithms that reflect disease specificity. In this work, we first proposed a novel approach to characterize the spatiotemporal variability of dynamic functional connectivity networks based on electroencephalography (EEG) microstate, and then developed a classification framework for integrating spatiotemporal variability of brain networks to improve early Parkinson's disease (PD) diagnostic performance. The experimental results indicated that compared with the brain network construction method based on conventional sliding window, the proposed method significantly improved the performance of early PD recognition, demonstrating that the dynamic spatiotemporal variability of microstate-based brain networks can reflect the pathological changes in the early PD brain. Furthermore, we observed that the spatiotemporal variability of early PD brain network has a specific distribution pattern in brain regions, which can be quantified as the degree of motor and cognitive impairment, respectively. Our work offers innovative methodological support for future research on brain network, and provides deeper insights into the spatiotemporal interaction patterns of brain activity and their variabilities in early PD.

9.
Article in English | MEDLINE | ID: mdl-37022414

ABSTRACT

The early Parkinson's disease (PD) with mild cognitive impairment (ePD-MCI) is a typical non-motor symptom reflected by the brain dysfunction of PD, which can be well depicted by the dynamic characteristics of brain functional connectivity networks. The aim of this study is to determine the unclear dynamic changes in functional connectivity networks induced by MCI in early PD patients. In this paper, the electroencephalogram (EEG) of each subject was reconstructed into the dynamic functional connectivity networks with five frequency bands based on adaptive sliding window method. By evaluating the fluctuations of dynamic functional connectivity and the transition stability of functional network state in ePD-MCI patients compared with early PD without mild cognitive impairment patients, it was found that in the alpha band, the functional network stability of central region, right frontal, parietal, occipital, and left temporal lobes was abnormally increased, and the dynamic connectivity fluctuations in these regions were significantly decreased in ePD-MCI group. In the gamma band, ePD-MCI patients showed decreased functional network stability in the central, left frontal, and right temporal lobes, and active dynamic connectivity fluctuations in the left frontal, temporal, and parietal lobes. The aberrant duration of network state in ePD-MCI patients was significantly negatively correlated with cognitive function in the alpha band, which might pave the way to identify and predict cognitive impairment in early PD patients.

10.
J Sep Sci ; 46(11): e2300006, 2023 Jun.
Article in English | MEDLINE | ID: mdl-37002792

ABSTRACT

A high-performance liquid chromatography-ultraviolet method was developed for rapidly and simultaneously analyzing novel and typical bisphenols in building materials, including bisphenol S, diphenolic acid, bisphenol F, bisphenol E, bisphenol A, bisphenol B, bisphenol AF, bisphenol AP, bisphenol C, bisphenol FL, bisphenol Z, bisphenol BP, bisphenol M, and bisphenol P. By using a Kromasil 100-5 C18 column, these bisphenols were completely separated in 40 min via gradually increasing the concentration of methanol in the mobile phase from 45 to 80% during the elution process. In particular, this method achieved the synchronous analysis of bisphenol S, diphenolic acid, bisphenol FL, bisphenol BP, and bisphenol M through HPLC, which were difficult to separate and had to be identified and detected through mass spectrometry. The limits of detection of the method ranged from 0.002 to 0.040 mg/L for these 14 bisphenols, with a precision of less than 4.9% (n = 7, c = 0.05 mg/L). The analytical results for five types of building materials (phenolic, epoxy, polycarbonate, polyester, and polysulfone resins) indicated that the proposed method is appropriated for the rapid measurement of bisphenols in real samples.

11.
ACS Pharmacol Transl Sci ; 6(3): 355-360, 2023 Mar 10.
Article in English | MEDLINE | ID: mdl-36926454

ABSTRACT

In cystic fibrosis (CF) the ability of the CF transmembrane conductance regulator (CFTR) protein to mediate chloride and water transport is disrupted. While much progress has been made in CF research leading to effective treatments to improve CFTR function, including small molecule modulators, patients present with varying disease manifestations and responses to therapy. For many CF-affected organs, disease onset is known to occur during in utero development before treatments can be administered and progresses over time leading to irreversible damage to these organs. Thus, the role of functional CFTR protein, in particular, during early development needs to be further elucidated. Studies have detected CFTR proteins at very early gestational stages and revealed temporally and spatially variable CFTR expression patterns in fetuses, suggesting a potential role of CFTR in fetal development. However, the actual mechanisms of how defective CFTR in CF results in fetal morphogenetic abnormalities are yet to be established. This review aims to summarize fetal CFTR expression patterns specifically in the lung, pancreas, and gastrointestinal tract (GIT), as compared to adult patterns. Case studies of structural abnormalities in CF fetuses and newborns and the role of CFTR in fetal development will also be discussed.

12.
Front Aging Neurosci ; 14: 911221, 2022.
Article in English | MEDLINE | ID: mdl-35903537

ABSTRACT

Objective: The aim of this study was to investigate the correlations of plasma neurodegenerative proteins and electroencephalography (EEG) dynamic functional network (DFN) parameters with disease progression in early Parkinson's disease (PD) with different motor subtypes, including tremor-dominant (TD) and postural instability and gait disorder (PIGD). Methods: In our study, 33 patients with PD (21 TD and 12 PIGD) and 33 healthy controls (HCs) were enrolled. Plasma neurofilament light chain (NfL), α-synuclein (α-syn), total-tau (t-tau), ß-amyloid 42 (Aß42), and ß-amyloid 40 (Aß40) levels were measured using an ultrasensitive single-molecule array (Simoa) immunoassay. All the patients with PD underwent EEG quantified by DFN analysis. The motor and non-motor performances were evaluated by a series of clinical assessments. Subsequently, a correlation analysis of plasma biomarkers and EEG measures with clinical scales was conducted. Results: In the TD group, plasma NfL exhibited a significant association with MDS-UPDRS III and Montreal Cognitive Assessment (MoCA). A higher Aß42/40 level was significantly related to a decrease in Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) in the PIGD group. In terms of the correlation between EEG characteristic parameters and clinical outcomes, trapping time (TT) delta was positively correlated with MDS-UPDRS III and MoCA scores in the TD group, especially in the prefrontal and frontal regions. For other non-motor symptoms, there were significant direct associations of k PLI theta with HAMD and HAMA, especially in the prefrontal region, and k PLI gamma was particularly correlated with Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ) scores in the prefrontal, frontal, and parietal regions in the TD group. Furthermore, there was a significant positive correlation between plasma t-tau and k PLI , and pairwise correlations were found among plasma NfL, theta TT, and MoCA scores in the TD group. Conclusion: These results provide evidence that plasma neurodegenerative proteins and EEG measures have great potential in predicting the disease progression of PD subtypes, especially for the TD subtype. A combination of these two kinds of markers may have a superposition effect on monitoring and estimating the prognosis of PD subtypes and deserves further research in larger, follow-up PD cohorts.

13.
J Chromatogr A ; 1674: 463137, 2022 Jul 05.
Article in English | MEDLINE | ID: mdl-35588592

ABSTRACT

A simplified sample pretreatment procedure was developed for quantitative measurement of nitrilotriacetic acid (NTA) in environmental water. On the basis of coordination capacity between NTA and metal ions, aluminum-based metal organic framework (MOF, MIL-53(Al)) was adopted for the adsorption of NTA, followed by stripping with copper sulfate as the eluent. The adsorbed NTA was converted into Cu-NTA during the desorption process, which facilitated the ensuing measurement by high performance liquid chromatography (HPLC). A linear range within 0.10 - 10 mg L-1 was achieved, along with a limit of detection (LOD, S/N=3, n=7) of 0.03 mg L-1 and an enrichment factor of 10.4. The developed method was validated by the analysis of sea water, influent of wastewater treatment plant and industrial wastewater, with satisfactory recoveries (90.2 - 91.1%) obtained.


Subject(s)
Metal-Organic Frameworks , Water Pollutants, Chemical , Adsorption , Chromatography, High Pressure Liquid/methods , Nitrilotriacetic Acid , Water Pollutants, Chemical/analysis
14.
Front Neurosci ; 16: 805953, 2022.
Article in English | MEDLINE | ID: mdl-35250451

ABSTRACT

OBJECTIVE: The aim of our study is to explore the most reliable panel of plasma biomarkers for differential diagnosis of parkinsonian syndromes (PDSs). We selected five kinds of neurodegenerative proteins in plasma: neurofilament light chain (NfL), α-synuclein (α-syn), total tau, ß-amyloid 42 (Aß42) and ß-amyloid 40 (Aß40), and investigated the diagnostic value of these biomarkers. METHODS: A total of 99 plasma samples from patients with Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy, and age-matched healthy controls (HCs) were enrolled in our study. Plasma NfL, α-syn, total tau, Aß42, and Aß40 levels were quantified by ultrasensitive single molecule array immunoassay. We used logistic regression analyses to examine diagnostic accuracy of these plasma biomarkers. Disease severity was assessed by the modified Hoehn and Yahr staging scale, Unified Parkinson's Disease Rating Scale part III (UPDRS III), and the Mini-Mental State Examination (MMSE), and subsequently, correlation analysis was performed. RESULTS: A combination of α-syn, Aß42, Aß40, Aß42/40, and NfL could achieve a best diagnostic value in differentiating PDSs from HC and PD from HC, with an AUC of 0.983 and 0.977, respectively. By adding NfL to measurements of α-syn or Aß42 or Aß40 or Aß42/40, the best discriminating panel was formed in differentiating atypical parkinsonian disorder (APD) and HC, and the discriminatory potential could reach a sensitivity of 100% and specificity of 100% (AUC = 1.000). For further distinguishing PD from APD, we found a combination of NfL, Aß42, and total tau was the most reliable panel with equally high diagnostic accuracy. With respect to differentiating the subtypes of APD from one another, our results revealed that measurement of NfL, total tau, Aß42, Aß40, and Aß42/40 was the best discriminating panel. Correlation analysis suggests that plasma Aß42 levels were positively correlated to UPDRS part III scores in MSA. In terms of cognitive function, there was a relationship between plasma Aß42/40 level and MMSE scores in patients with APD. CONCLUSION: In our study, various combinations of plasma biomarkers have great potentialities in identifying PDSs, with important clinical utility in improving diagnostic accuracy. Plasma NfL may have added value to a blood-based biomarker panel for differentiating PDSs.

15.
J Neural Eng ; 18(6)2021 12 24.
Article in English | MEDLINE | ID: mdl-34875634

ABSTRACT

Objective.Parkinson's disease (PD) is one of the most common neurodegenerative diseases, and early diagnosis is crucial to delay disease progression. The diagnosis of early PD has always been a difficult clinical problem due to the lack of reliable biomarkers. Electroencephalogram (EEG) is the most common clinical detection method, and studies have attempted to discover the EEG spectrum characteristics of early PD, but the reported conclusions are not uniform due to the heterogeneity of early PD patients. There is an urgent need for a more advanced algorithm to extract spectrum characteristics from EEG to satisfy the personalized requirements.Approach.The structured power spectral density with spatial distribution was used as the input of convolutional neural network (CNN). A visualization technique called gradient-weighted class activation mapping was used to extract the optimal frequency bands for identifying early PD. Based on the model visualization, we proposed a novel quantitative index of spectral characteristics, spatial-mapping relative power (SRP), to detect personalized abnormalities in the spatial spectral characteristics of EEG in early PD.Main results.We demonstrated the feasibility of applying CNN to identify the patients with early PD with an accuracy of 99.87% ± 0.03%. The models indicated the characteristic frequency bands (high-delta (3.5-4.5 Hz) and low-alpha (7.5-11 Hz) frequency bands) that are used to identify the early PD. The SRP of these two characteristic bands in early PD patients was significantly higher than that in the control group, and the abnormalities were consistent at the group and individual levels.Significance.This study provides a novel personalized detection algorithm based on deep learning to reveal the optimal frequency bands for identifying early PD and obtain the spatial frequency characteristics of early PD. The findings of this study will provide an effective reference for the auxiliary diagnosis of early PD in clinical practice.


Subject(s)
Deep Learning , Parkinson Disease , Electroencephalography/methods , Humans , Neural Networks, Computer , Parkinson Disease/diagnosis
16.
Sci Total Environ ; 801: 149791, 2021 Dec 20.
Article in English | MEDLINE | ID: mdl-34467899

ABSTRACT

CO2 absorption and microalgae conversion (CAMC) hybrid system is a promising alternative for simultaneous carbon capture and utilization. It can not only overcome the challenge of high energy consumption solvent thermal regeneration in chemical CO2 absorption, but also enhance the carbon conversion efficiency in biological conversion process. However, the discordance between CO2 absorption and bio-conversion rate has become the key to limiting the development of CAMC system. Therefore, in this study, low temperature plasma (LTP) mutation breeding technology was used to training Chlorella strains by combining undirected mutagenesis and directional screening. Then, the mutagenic microalgae were cultivated and evaluated in CAMC system. It was found that compared with original Chlorella L166, the OD680 of mutant strain L166-M3 in CAMC system increased 7.8%, and the maximum specific growth rate improved 27.5%. The carbon sequestration rate of wild Chlorella L166 increased from 82.9% to 93.7% after mutation treatment, the activity of RubisCO, and the content of NADPH produced by photoreaction increased 37.2% and 17.2%. In addition, lipid production of L166-M3 increased to 6.89 mg/L, which was 15.4% higher than original Chlorella L166. It could be observed that LTP mutation breeding could be used as a potential method for training algae species and improve the overall performance of CAMC system.


Subject(s)
Chlorella , Microalgae , Biomass , Carbon Dioxide , Plant Breeding , Temperature
17.
Talanta ; 232: 122499, 2021 Sep 01.
Article in English | MEDLINE | ID: mdl-34074451

ABSTRACT

In this work, ZnO nanorods (ZnO NRs) with different sizes were hydrothermally grown on the surface of Whatman filter paper for the fabrication of a microfluidic paper-based device (µPAD) for the simultaneous detection of glucose and uric acid. As dual enzymatic reaction was employed for the colorimetric detection in this µPAD, the presence of ZnO NRs promoted the enzyme immobilization thus significantly enhancing the colorimetric signal. The coffee ring effect was effectively conquered by the uniform distribution of ZnO NR as well as a specialized double-layered µPAD design. Meanwhile, two color indicators with distinct colors were used to provide complementary results to better quantify the concentration of the analytes by naked eye. As a result, two linear calibration curves were obtained for the detection of glucose (0.01-10 mmol L-1) and uric acid (0.01-5 mmol L-1), along with a LOD of 3 µmol L-1 for glucose and 4 µmol L-1 for uric acid, respectively. The practical usefulness of the proposed µPAD was further validated by the simultaneous analysis of glucose and uric acid in serum samples and urine samples.


Subject(s)
Microfluidic Analytical Techniques , Nanotubes , Zinc Oxide , Microfluidics , Paper
18.
Chem Asian J ; 16(12): 1603-1607, 2021 Jun 14.
Article in English | MEDLINE | ID: mdl-33913257

ABSTRACT

Enzyme-mimicking artificial nanomaterials often termed nanozymes have broad applications in many fields, including biosensing, pollutant degradation and cancer diagnosis. Herein, we introduce a plasmonic gold nanoparticle-modified Mn3 O4 nanozyme (Mn3 O4 -Au). Visible or near infrared light excitation into the plasmonic absorption band of the surface-bound gold nanoparticles enhances the catalytic oxidation of tetramethylbenzidine (TMB). The mechanism of light-enhanced peroxidase activity is proposed based on the Mn3 O4 conduction band mediated hot electron transfer from photoexcited gold nanoparticles to H2 O2 which undergoes further oxygen-oxygen bond cleavage to yield hydroxyl radical. The surface decoration of plasmonic gold nanoparticles endows Mn3 O4 -Au to be a light-regulated nanozyme.

19.
J Chem Phys ; 152(8): 084302, 2020 Feb 28.
Article in English | MEDLINE | ID: mdl-32113370

ABSTRACT

We present an experimental observation of 37D5/2 + 6S1/2Cs2 Rydberg-ground molecules by employing a two-photon photoassociation method. Two distinct Rydberg-ground molecular signals, deep and shallow bound molecules, are observed at the red detuning of atomic line. In theory, the model of scattering interaction between the Rydberg electron and ground-state atom is used to simulate the experiments. Two potential energy curves with energy minimum, deep pure triplet 3Σ and shallow hyperfine-mixed singlet-triplet 1,3Σ potentials, refer to the attained Rydberg-ground molecular signals, respectively. Calculations of the binding energy of triplet 3Σ and mixed 1,3Σv = 0 states are compared with the measurements. The agreement between the calculated and measured values of the binding energy yields zero-energy scattering lengths as T(0) = -19.2a0 and as S(0) = -1.3a0, respectively.

20.
Chemosphere ; 248: 126094, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32041073

ABSTRACT

Microalgae have been considered as promising alternative for CO2 fixation and wastewater purification. In our previous work, a hybrid microalgae CO2 fixation concept has been put forward, which initially used carbonate solution absorb CO2, and then provided obtained bicarbonate as nutrition for microalgae growth to avoid the challenge of low CO2 solubility and carbon fixation efficiency in the conventional process. In this work, the proposed hybrid system was further intensified via integrating soybean wastewater nutrition removal with bicarbonate-carbon (NH4HCO3 and KHCO3) conversion. The investigation results indicated that the maximum biomass productivity (0.74 g L-1) and carbon bioconversion efficiency (46.9%) were achieved in low-NH4HCO3 concentration system with pH adjusted to 7. pH adjustment of different bicarbonate systems also enhanced total nitrogen (TN), total phosphorus (TP) and chemical oxygen demand (COD) removal efficiency up to 87.5%, 99.5% and 77.6%, respectively. In addition, maximum neutral lipid (14.4 mg L-1·d-1) and polysaccharide (14.5 mg L-1·d-1) productivities could be obtained in the KHCO3 systems, while higher crude protein productivity (48.1 mg L-1·d-1) was yielded in the NH4HCO3 systems.


Subject(s)
Bicarbonates/chemistry , Carbon Cycle , Glycine max/metabolism , Microalgae/metabolism , Potassium Compounds/chemistry , Wastewater/chemistry , Water Purification/methods , Biological Oxygen Demand Analysis , Biomass , Carbon/metabolism , Carbon Dioxide/metabolism , Hydrogen-Ion Concentration , Microalgae/growth & development , Nitrogen/metabolism , Phosphorus/metabolism , Recycling
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