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1.
Carbohydr Polym ; 268: 118257, 2021 Sep 15.
Article in English | MEDLINE | ID: mdl-34127228

ABSTRACT

Multifunctional theranostic nanoplatforms integrated of imaging function, multi-modality therapy, stimuli-responsiveness, and targeted delivery are of highly desirable attributes in achieving precise medicine. However, preparation of multifunctional nanoplatforms often involves laborious, multiple steps and inevitably utilizes low-biocompatible or non-functional components. Herein we report a facile, one-step self-assembly strategy to fabricate hyaluronic acid (HA)-based multifunctional tumor theranostic nanoplatform by employing magnetic resonance imaging (MRI) agent Mn2+ as a reversible crosslink agent for histidine-grafted HA, along with simultaneously loading chemotherapeutic agent doxorubicin hydrochloride (DOX) and photodynamic therapy agent chlorin e6, to realize MRI-guided targeted chemo-photodynamic cancer therapy. The targeted delivery and stimuli-responsive payload release were demonstrated in vitro and in vivo. Furthermore, the combined chemo-photodynamic therapy of the nanoassembly dramatically improved the cancer therapeutic outcome, in comparison with that of free DOX and nanoplatform solely loaded DOX in a melanoma bearing mice. Our one step assemble strategy is of great potential in clinic transformation.


Subject(s)
Antineoplastic Agents/therapeutic use , Drug Carriers/chemistry , Nanogels/chemistry , Neoplasms/diagnostic imaging , Neoplasms/drug therapy , Photosensitizing Agents/therapeutic use , Animals , Cell Line, Tumor , Chlorophyllides , Doxorubicin/therapeutic use , Drug Carriers/toxicity , Histidine/chemistry , Histidine/toxicity , Hyaluronic Acid/analogs & derivatives , Hyaluronic Acid/toxicity , Light , Manganese/chemistry , Manganese/toxicity , Mice, Inbred C57BL , Nanogels/toxicity , Photochemotherapy , Photosensitizing Agents/radiation effects , Porphyrins/radiation effects , Porphyrins/therapeutic use , Precision Medicine/methods , Singlet Oxygen/metabolism
2.
World J Gastroenterol ; 26(14): 1674-1682, 2020 Apr 14.
Article in English | MEDLINE | ID: mdl-32327915

ABSTRACT

BACKGROUND: Gastrointestinal hemangiomas are rare benign tumors. According to the size of the affected vessels, hemangiomas are histologically classified into cavernous, capillary, or mixed-type tumors, with the cavernous type being the most common and racemose hemangiomas being very rare in the clinic. Melena of uncertain origin and anemia are the main clinical manifestations, and other presentations are rare. Due to the rarity of gastrointestinal hemangiomas and lack of specific manifestations and diagnostic methods, preoperative diagnoses are often delayed or incorrect. CASE SUMMARY: We report a 5-year-old girl who presented with abdominal pain, nausea, and vomiting for a duration of 10 h. The laboratory studies showed prominent anemia. Computed tomography and contrast-enhanced computed tomography of the abdomen revealed a small bowel obstruction caused by a giant abdominal mass. Segmental resection of the ileal lesions was performed through surgery, and the final pathology results revealed a diagnosis of racemose hemangioma complicated by a small bowel obstruction and simultaneous chronic anemia. CONCLUSION: The current report will increase the understanding of the diagnosis and treatment of gastrointestinal hemangiomas and provide a review of the related literature.


Subject(s)
Anemia/etiology , Hemangioma/diagnosis , Ileal Neoplasms/diagnosis , Intestinal Obstruction/etiology , Melena/etiology , Child, Preschool , Chronic Disease , Diagnosis, Differential , Female , Hemangioma/complications , Hemangioma/pathology , Hemangioma/surgery , Humans , Ileal Neoplasms/complications , Ileal Neoplasms/pathology , Ileal Neoplasms/surgery , Ileum/diagnostic imaging , Ileum/pathology , Ileum/surgery , Intestinal Obstruction/surgery , Laparoscopy , Melena/surgery , Teratoma/diagnosis , Tomography, X-Ray Computed , Treatment Outcome
3.
J Nanosci Nanotechnol ; 15(12): 9539-47, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26682376

ABSTRACT

Nanostructured lipid carriers (NLC) are a promising pharmaceutical delivery system with mean diameter less than 200 nm which are dispersed in an aqueous phase containing emulsifier(s), to increase the water solubility, stability and bioavailability of oil compounds. Herein we prepared a promising NLC with glyceryl monostearate (GMS) as the solid lipid template and deep sea fish oil as the liquid lipid template using melted-ultrasonic method. Fish oil-NLC had a mean size of 84.7 ± 2.6 nm and a zeta potential that ranged from -17.87 mV to -32.91 mV. The nanoparticles exhibited good stability for four weeks with a high encapsulation efficiency of 87.5 ± 5.2%. Afterwards, confocal laser scanning microscopy (CLSM) and flow cytometry (FCM) were used to investigate the contribution of Fish oil-NLC in enhancing fluorescein isothiocyanate (FITC) cellular uptake in comparison with free FITC. The results of this study indicated the possibility of this carrier to overcome the shortcomings of deep sea fish oil and to provide a novel bifunctional carrier with nutritional potential and drug delivery ability.


Subject(s)
Drug Carriers/chemistry , Fish Oils/chemistry , Lipids/chemistry , Nanostructures/chemistry , Cell Line , Fish Oils/pharmacokinetics , Humans , Particle Size
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