ABSTRACT
Objective: To study the effect of microcrystalline cellulose (MCC) on compressibility and moldability of Galla chinensis extract (GCE). Methods: Four types of MCC were chosen and mixed with GCE respectively in different proportions. The powder was tabletted by Korsch XP-1 Intelligent Induction Tablet Machine, and the compressibility and moldability were evaluated using plasticity constant, elastic recovery, compression ratio, yield pressure, tensile strength, and their change rules as indexes. Results: The compressibility and moldability of GCE were poor. CeolusKG802 was the best at improving elastic recovery and compression ratio among the four kinds of MCC. AvicelDG improved the plasticity constant and tensile strength most when the adding amount was low, and CeolusKG802 improved them most when the adding amount was high. To yield pressure, CeolusKG802 exhibited greater reduction than the other MCC when added in a low amount. As for a high amount, the result was opposite. Conclusion: MCC has good compressibility and moldability in the compression process; Different types of MCC have different advantages. The change law of compression parameters is obtained by investigating the compression of mixed powders of MCC with different proportions on GCE.
ABSTRACT
In this paper, microcrystalline cellulose WJ101 was used as a model material to investigate the effect of various process parameters on granule yield and friability after dry granulation with a single factor and the effect of comprehensive inspection process parameters on the effect of granule yield and friability, then the correlation between process parameters and granule quality was established. The regress equation was established between process parameters and granule yield and friability by multiple regression analysis, the affecting the order of the size of the order of the process parameters on granule yield and friability was: rollers speed > rollers pressure > speed of horizontal feed. Granule yield was positively correlated with pressure and speed of horizontal feed and negatively correlated rollers speed, while friability was on the contrary. By comparison, fitted value and real value, fitted and real value are basically the same of no significant differences (P > 0.05) and with high precision and reliability.
