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Clin Infect Dis ; 70(5): 933-936, 2020 02 14.
Article in English | MEDLINE | ID: mdl-31233122

ABSTRACT

The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.


Subject(s)
Bacteremia , Bacteriophages , Mycobacterium tuberculosis , Tuberculosis, Pulmonary , Tuberculosis , Animals , Bacteremia/diagnosis , Humans , Tuberculosis, Pulmonary/diagnosis
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