1.
Methods Mol Biol
; 1872: 61-65, 2019.
Article
in English
| MEDLINE
| ID: mdl-30350279
ABSTRACT
Tapentadol is an orally active analgesic with a similar structure to tramadol. Its primary mechanism of action is agonist action on the mu-opioid receptor. The method described here quantitates tapentadol in the whole blood using a matching deuterated internal standard, extraction via a protein "crash" with acetonitrile, followed by analysis using liquid chromatography-tandem mass spectrometry.