ABSTRACT
INTRODUCTION: Many clinical manifestations can be related to Tropheryma whipplei infection. CASE REPORT: We report a Tropheryma whipplei limbic encephalitis developed as a relapse of classical Whipple's disease. DISCUSSION: This case is to the best of our knowledge the first proof of the effective brain-blood barrier crossing of both doxycycline and hydroxychloroquine as demonstrated by direct concentration monitoring on brain biopsy.
Subject(s)
Limbic Encephalitis/diagnosis , Tropheryma/isolation & purification , Whipple Disease/diagnosis , Biopsy , Cerebrum/pathology , Humans , Immunohistochemistry , Limbic Encephalitis/microbiology , Limbic Encephalitis/pathology , Male , Middle Aged , Polymerase Chain Reaction , Recurrence , Whipple Disease/complications , Whipple Disease/pathologyABSTRACT
The incidence of HIV associated neurocognitive disorders (HAND) were reduced with the use of antiretroviral therapy. In case of neuropsychiatric symptoms, after elimination of all infections, auto-immune encephalitis could be evocated as a differential diagnosis. We describe a case of anti-N-Methyl-d-Aspartate receptor encephalitis in an HIV-1 infected woman.
Subject(s)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/immunology , Autoantibodies/cerebrospinal fluid , HIV Infections/immunology , HIV-1/physiology , Receptors, N-Methyl-D-Aspartate/immunology , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/drug therapy , Anxiety , Diagnosis, Differential , Electrocardiography , Female , HIV Infections/diagnosis , HIV Infections/drug therapy , Humans , Immunoglobulins, Intravenous/therapeutic use , Memory Disorders , Middle Aged , Recovery of Function , Sleep Initiation and Maintenance DisordersSubject(s)
Listeria monocytogenes/physiology , Listeriosis/complications , Liver Cirrhosis/complications , Liver Cirrhosis/diagnosis , Peritonitis/microbiology , Abdominal Pain/diagnosis , Abdominal Pain/etiology , Abdominal Pain/microbiology , Aged, 80 and over , Diagnosis, Differential , Humans , Listeria monocytogenes/isolation & purification , Listeriosis/diagnosis , Liver Cirrhosis/microbiology , Male , Peritonitis/complicationsABSTRACT
A 29-year-old kidney transplant recipient returning from Mali was diagnosed with Rift Valley fever (RVF) in France in autumn 2015. The patient was immunosuppressed due to his renal transplant. IgM and IgG specific to RVF virus (RVFV) were detected in cerebrospinal fluid and blood up to two months after symptom onset, whereas in urine, RVFV genomic RNA was detected by RT-PCR up to three months, and in semen up to four months post symptom onset.
