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1.
J Virol ; 79(16): 10821-5, 2005 Aug.
Article in English | MEDLINE | ID: mdl-16051873

ABSTRACT

To determine whether avian H5N1 influenza viruses associated with human infections in Vietnam had transmitted to pigs, we investigated serologic evidence of exposure to H5N1 influenza virus in Vietnamese pigs in 2004. Of the 3,175 pig sera tested, 8 (0.25%) were positive for avian H5N1 influenza viruses isolated in 2004 by virus neutralization assay and Western blot analysis. Experimental studies of replication and transmissibility of the 2004 Asian H5N1 viruses in pigs revealed that all viruses tested replicated in the swine respiratory tract but none were transmitted to contact pigs. Virus titers from nasal swabs peaked on day 2, and low titers were detected in the liver of two of the four pigs tested. Our findings indicate that pigs can be infected with highly lethal Asian H5N1 viruses but that these viruses are not readily transmitted between pigs under experimental conditions.


Subject(s)
Influenza A Virus, H5N1 Subtype , Influenza A virus/isolation & purification , Orthomyxoviridae Infections/veterinary , Swine Diseases/virology , Animals , Orthomyxoviridae Infections/pathology , Orthomyxoviridae Infections/transmission , Swine , Swine Diseases/pathology
2.
Nature ; 430(6996): 209-13, 2004 Jul 08.
Article in English | MEDLINE | ID: mdl-15241415

ABSTRACT

A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2-4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003-04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required.


Subject(s)
Evolution, Molecular , Influenza, Human/epidemiology , Influenza, Human/virology , Orthomyxoviridae/genetics , Orthomyxoviridae/pathogenicity , Animals , Birds/virology , Asia, Eastern/epidemiology , Genes, Viral/genetics , Genotype , Humans , Influenza, Human/transmission , Molecular Sequence Data , Mutation/genetics , Orthomyxoviridae/isolation & purification , Phylogeny , Reassortant Viruses/genetics , Reassortant Viruses/isolation & purification , Reassortant Viruses/pathogenicity , Time Factors
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