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1.
Ann Thorac Surg ; 66(1): 193-8, 1998 Jul.
Article in English | MEDLINE | ID: mdl-9692463

ABSTRACT

BACKGROUND: The evolution of therapy in 105 patients with superior sulcus (Pancoast) tumor over the past 42 years was reviewed. METHODS: There were 82 men and 23 women aged 30 to 75 years. Tumor cell types were: squamous, 41 (39%); adenocarcinoma, 23 (21.9%); anaplastic, 14 (13.3%); undetermined, 12 (11.4%); mixed, 9 (8.7%); and large cell 6 (5.7%). Therapy was based on extent of disease and lymph node involvement. There were 5 treatment groups: I, preoperative radiation and operation (n = 28); II, operation and postoperative radiation (n = 16); III, radiation (n = 37); IV, preoperative chemotherapy, radiation, and operation (n = 11); and V, operation (n = 12). RESULTS: The median survival for group I was 21.6 months; group II, 6.9 months; group III, 6 months; and group V, 36.7 months. Median survival for group IV has not yet been reached (estimated at 72% at 5 years). On univariate analysis, mediastinal lymph node involvement, Horner syndrome, TNM classification, and method of therapy affected survival. On multivariate regression analysis, only N2 and N3 disease and method of therapy were significant (p < 0.05). CONCLUSIONS: The optimal treatment for superior sulcus tumor was preoperative radiation and operation. However, triple modality therapy, although promising, requires longer follow-up.


Subject(s)
Pancoast Syndrome/therapy , Adenocarcinoma/pathology , Adult , Aged , Analysis of Variance , Anaplasia , Carcinoma, Large Cell/pathology , Carcinoma, Squamous Cell/pathology , Chemotherapy, Adjuvant , Female , Follow-Up Studies , Horner Syndrome/etiology , Humans , Lymphatic Metastasis/pathology , Male , Mediastinum , Middle Aged , Multivariate Analysis , Neoplasm Staging , Pancoast Syndrome/pathology , Pancoast Syndrome/radiotherapy , Pancoast Syndrome/surgery , Pneumonectomy , Radiotherapy, Adjuvant , Regression Analysis , Retrospective Studies , Survival Rate
2.
Ann Thorac Surg ; 59(6): 1410-5; discussion 1415-6, 1995 Jun.
Article in English | MEDLINE | ID: mdl-7771819

ABSTRACT

Paraplegia complicating thoracotomy is rare but catastrophic. This report comprises 40 cases: 5 of our cases and 35 reported cases. Our cases comprised a stab wound of the left chest (1), decortication (1), lobectomy for bronchogenic carcinoma (2), and segmental resection for tuberculosis (1). The reported cases included 25 cases following thoracotomy for thoracic pathology (bronchogenic carcinoma, 12; pulmonary tuberculosis, 7; thoracic trauma, 2; bronchiectasis, 1; peptic esophagitis, 1; neurogenic tumors, 2; and benign lung lesion, 1 and 10 cases following operation for malignant hypertension. The surgical procedures performed on the 25 patients with thoracic pathology were lobectomy (8), bilobectomy (1), pneumonectomy (7), decortication (1), thoracoplasty (1), excision of neurogenic tumors (2), drainage of tuberculous cavity (1), and Nissen procedure (1). The intraoperative factors contributing to the neurologic deficit were bleeding at the costovertebral angle (9), migration of oxidized cellulose into spinal canal (9), thrombosis of anterior spinal artery (4), epidural hematoma (2), epidural narcotic (2), metastatic carcinoma (1), and hypotension (1). This serious complication can be prevented by meticulous operation and careful hemostasis. The immediate use of tomographic scanning or magnetic resonance imaging followed by surgical decompression might avert this serious complication.


Subject(s)
Paraplegia/etiology , Thoracotomy/adverse effects , Adult , Female , Humans , Male , Middle Aged , Monitoring, Intraoperative , Paraplegia/prevention & control , Thoracotomy/methods , Treatment Outcome
3.
Ann Thorac Surg ; 51(5): 711-5; discussion 715-6, 1991 May.
Article in English | MEDLINE | ID: mdl-2025073

ABSTRACT

One hundred nine penetrating cardiac injuries were reviewed: 49 gunshot wounds and 60 stab wounds. They were classified into four groups: group 1 (lifeless), 38; group 2 (agonal), 16; group 3 (shock), 33; and group 4 (stable), 22. Thirty-six patients in group 1 (94%) and 8 of 16 patients in group 2 (50%) underwent emergency room thoracotomy; 24 of 33 in group 3 (73%) and 20 of 22 (90%) underwent thoracotomy in the operating room. Twenty-one (38%) of 55 patients undergoing emergency room thoracotomy survived, whereas 47 (87%) of 54 patients undergoing operating room thoracotomy survived. Survival was 12 of 38 (31%) in group 1, 11 of 16 (69%) in group 2, 26 of 33 (79%) in group 3, and 18 of 22 (82%) in group 4 with an overall survival of 67 of 109 (61%). Gunshot wounds of the heart portend a worse prognosis than stab wounds. Survival of gunshot wounds was 20 of 49 (40%) compared with 47 survivors of 60 stab wounds (78%). Aggressive treatment, including emergency room thoracotomy, is justified for lifeless and deteriorating cardiac injury victims.


Subject(s)
Heart Injuries/mortality , Wounds, Penetrating/mortality , Adolescent , Adult , Aged , Aged, 80 and over , Child , Emergencies , Female , Heart Injuries/surgery , Humans , Injury Severity Score , Male , Middle Aged , Multiple Trauma/mortality , Prognosis , Survival Rate , Thoracotomy/mortality , Wounds, Penetrating/surgery
4.
J Thorac Cardiovasc Surg ; 100(5): 652-60; discussion 660-1, 1990 Nov.
Article in English | MEDLINE | ID: mdl-2232829

ABSTRACT

During the 15 years from 1971 through 1985, 114 patients with rupture of the thoracic aorta caused by blunt trauma were admitted to the Shock Trauma Center of the Maryland Institute for Emergency Medical Services Systems. Mean age was 31.3 years (range, 15 to 80). Ninety were male and 24 were female, a 3.75:1 ratio. Of the 114, 89 (78.1%) survived initial resuscitation in the admitting area. Twenty five of the 89 initial survivors (28.1%) died during or after surgical repair. Paraplegia occurred in 11 of the 78 operating room survivors (14.1%). Further analysis was done of the 83 patients admitted in the 10-year period from 1976 through 1985. Mean Injury Severity Score, excluding aortic injury, was 18.2. Twenty-five of the 83 (30.1%) died during resuscitation in the admitting area or operating room. Seven others died during surgical repair and 12 died postoperatively, leaving 39 survivors (39/83 [47%] of total admissions and 39/58 [67.2%] of survivors of resuscitation). Paraplegia/paresis developed postoperatively in six of 34 (17.6%) cases involving shunt and four of 17 (23.5%) without shunt. Other major complications occurred in 21 of the operating room survivors. Statistically significant risk of death or major complication was associated with female sex, higher Injury Severity Score, lower admission blood pressure, larger hemothorax on admission, less qualified surgeon, major operation before aortic repair, use of shunt, and transfer directly from scene of injury. There was no advantage in this series to using or not using a shunt in preventing paraplegia. Mortality rates are realistic for a highly developed trauma system. Better techniques are needed to manage exsanguination and prevent paraplegia.


Subject(s)
Aorta, Thoracic/surgery , Wounds, Nonpenetrating/surgery , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Postoperative Complications , Retrospective Studies , Risk Factors , Rupture
5.
Ann Thorac Surg ; 50(1): 45-9; discussion 50-1, 1990 Jul.
Article in English | MEDLINE | ID: mdl-2369229

ABSTRACT

The records of 64 patients with esophageal perforation treated since 1958 were reviewed. There were 19 cervical perforations, 44 thoracic perforations, and one abdominal perforation. Thirty-one perforations (48%) were due to injury from intraluminal causes. Twenty (31%) resulted from extraluminal causes: penetrating wounds, 11; blunt trauma, 3; and paraesophageal operations, 6. Eleven (17%) were spontaneous perforations, and two (3%) were caused by perforation of an esophageal malignancy. Ten (91%) of 11 patients with cervical perforations treated less than 24 hours after injury survived compared with 6 (75%) of 8 patients treated more than 24 hours after injury; hence 16 (84%) of the 19 patients in the cervical group survived. In the thoracic group, 19 patients were treated within 24 hours with 16 survivors (84%) compared with 25 patients treated beyond 24 hours with 12 survivors (48%); hence 28 (64%) of the 44 patients in the thoracic group survived. The patient with an abdominal perforation survived. Thirty patients underwent primary suture closure of the perforation, and 25 (83%) lived. Seventeen patients had drainage, and 10 (59%) lived. Total esophagectomy was performed in 9 patients, 7 (78%) of whom survived. Exclusion-diversion procedures were performed in 5 patients, and 1 (20%) survived.


Subject(s)
Esophageal Perforation/surgery , Adult , Age Factors , Esophageal Diseases/complications , Esophageal Perforation/etiology , Esophageal Perforation/pathology , Esophagus/injuries , Esophagus/surgery , Female , Humans , Male , Middle Aged , Prognosis , Risk Factors , Survival Rate , Time Factors , Wounds, Penetrating/complications
6.
Ann Thorac Surg ; 47(5): 700-5, 1989 May.
Article in English | MEDLINE | ID: mdl-2730191

ABSTRACT

The cases of 78 patients with primary esophageal carcinoma treated from 1977 to mid-1987 were retrospectively analyzed. Fifty-two of the patients underwent transthoracic esophagogastrectomy (TTE) and 26, transhiatal esophagectomy (THE). The two groups were statistically similar in preoperative characteristics except that more of the THE group had received chemotherapy; this group had relatively more tumors of the upper esophagus; and 20 (77%) of the THE group, compared with 50 (96%) of the TTE group, had tumors in stages III and IV. The incidence of major postoperative complications did not differ significantly between the two groups. There were five (19%) anastomotic leaks in the THE group, but only one led to a prolongation of hospital stay by more than 14 days, whereas all three (6%) of the leaks in the TTE group caused hospital stay to be prolonged several weeks. Overall morbidity was high: 75% (39/52) for the TTE patients and 85% (22/26) for the THE patients (p greater than 0.10). Hospital mortality was 6% (3/52) in the TTE group and 8% (2/26) in the THE patients (p greater than 0.10). There was no significant difference in actuarial survival either between the two groups as a whole or between those patients in each group who had stage III or IV tumors. We conclude that THE, among the types of patients for whom we used the procedure, provides long-term survival comparable with that provided by TTE without causing a significant increase in hospital mortality or morbidity.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Esophageal Neoplasms/surgery , Esophagus/surgery , Actuarial Analysis , Esophageal Neoplasms/mortality , Esophageal Neoplasms/pathology , Female , Gastrectomy/methods , Humans , Male , Methods , Middle Aged , Postoperative Complications , Retrospective Studies
7.
Ann Thorac Surg ; 46(3): 278-82, 1988 Sep.
Article in English | MEDLINE | ID: mdl-3046520

ABSTRACT

Survival after repair of postinfarction ventricular septal defects remains poor, often due to extensive loss of contractile muscle in the septum or left ventricle. We evaluated whether a contractile flap of right ventricular muscle could be used to repair a similar ventricular septal defect to augment left ventricular performance in 7 fully instrumented mongrel dogs (weight, 23 to 28 kg). By using hypothermic bypass and cold fibrillatory arrest, a trapezoidal right ventricle flap was fashioned from the free wall of the mid to lower right ventricle, basing its widest portion anteriorly on the septum and left ventricle. A large, 2-cm-diameter core of septum was excised beneath this flap to simulate a postinfarct ventricular septal defect. The right ventricular flap was then invaginated through the defect and sewn to the left ventricular side of the septum with pledgeted sutures taken full thickness through the flap and septum in a "vest-over-pants" fashion. Contraction of the right ventricular flap was confirmed visually and by postbypass multiple gated acquisition scans. The right ventricular defect was closed with fascia lata. All dogs were weaned from bypass without inotropes. Precardiac and postcardiac outputs of 2.5 +/- 0.5 versus 2.3 +/- 0.4 L/min and left ventricular end-diastolic pressures of 4 +/- 2 versus 4 +/- 3 mm Hg were identical. No shunts were detected by oxygen saturation. Autopsies confirmed the integrity of the repair. We conclude that septal defects can be repaired by using contractile right ventricular muscle, thus preserving left ventricular function. This technique offers promise for repair of postinfarction ventricular septal defects by using autologous, already conditioned to contract, cardiac muscle, but its application in humans must await long-term testing.


Subject(s)
Heart Septal Defects, Ventricular/surgery , Surgical Flaps , Animals , Cardiopulmonary Bypass , Disease Models, Animal , Dogs , Evaluation Studies as Topic , Heart Septal Defects, Ventricular/physiopathology , Heart Ventricles/surgery , Humans , Myocardial Contraction , Suture Techniques
8.
Ann Thorac Surg ; 46(1): 24-8, 1988 Jul.
Article in English | MEDLINE | ID: mdl-3289517

ABSTRACT

Between 1964 and 1986, 19 patients underwent resection of both a primary lung cancer and the associated brain metastasis. One patient underwent resection of 2 separate primary lung cancers and the associated metastases. The 12 men and 7 women ranged in age from 42 to 67 years (mean, 54.6 years). The cell type was adenocarcinoma in 12 tumors, squamous or adenosquamous cell in 5, large cell undifferentiated or anaplastic in 2, and malignant carcinoid in 1 tumor. The types of resection were as follows: lobectomy for 12 neoplasms, pneumonectomy for 5, bilobectomy for 2, and wedge resection for 1 neoplasm. Radiotherapy to the brain was given in connection with sixteen of the twenty craniotomies. The patient with 2 separate primary neoplasms survived 19 years before dying 5 months after the second craniotomy. The mean survival is 8.0 +/- 2.1 years (+/- the standard error), and the median survival is 1.67 years. Survival at 1 year was 65 +/- 10.7% and at 5 years, 45 +/- 11.1%. On univariate analysis, the following factors were found to correlate significantly with longer survival: a lung tumor in Stage I or II; negative mediastinal nodes; curative rather than palliative resection of the lung tumor; and age younger than 55 years. However, on multivariate analysis, only curative resection was a significant factor (p less than 0.01). We believe these results justify continued application of this combined surgical approach to patients having limited-stage lung cancer with a solitary brain metastasis.


Subject(s)
Adenocarcinoma/surgery , Brain Neoplasms/surgery , Carcinoid Tumor/surgery , Carcinoma, Squamous Cell/surgery , Carcinoma/surgery , Lung Neoplasms/surgery , Adenocarcinoma/pathology , Adenocarcinoma/radiotherapy , Adenocarcinoma/secondary , Adult , Aged , Brain Neoplasms/pathology , Brain Neoplasms/radiotherapy , Brain Neoplasms/secondary , Carcinoid Tumor/pathology , Carcinoid Tumor/radiotherapy , Carcinoid Tumor/secondary , Carcinoma/pathology , Carcinoma/radiotherapy , Carcinoma/secondary , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/radiotherapy , Carcinoma, Squamous Cell/secondary , Combined Modality Therapy , Female , Humans , Lung Neoplasms/pathology , Lung Neoplasms/radiotherapy , Lymph Node Excision , Male , Mediastinum , Middle Aged , Neoplasm Staging , Prognosis , Time Factors
9.
Ann Thorac Surg ; 44(2): 123-7, 1987 Aug.
Article in English | MEDLINE | ID: mdl-3619536

ABSTRACT

Transhiatal esophagectomy was performed in 26 patients with esophageal carcinoma. The patients were selected for this procedure by means of transhiatal palpation of the tumor at laparotomy. Twenty had squamous cell carcinoma and 6, adenocarcinoma. The tumor locations were the upper third in 8, middle third in 12, and lower third in 6. On postoperative staging, 15 patients had Stage III and 6, Stage IV neoplasms. Among 25 elective resections there was 1 hospital death, which was due to severe coronary artery disease. One patient who had an urgent resection for a perforated carcinoma died of multisystem failure 32 days postoperatively. Complications included splenic injury requiring splenectomy in 5 patients; tracheal laceration in 2 patients (only 1 requiring a thoracotomy); azygos vein laceration requiring sternotomy for repair in 1 patient; chylothorax in 1; recurrent laryngeal nerve paralysis in 3 (temporary in 2); and transient anastomotic leaks in 3. Five patients had pneumonia with transient respiratory failure. Twelve of the operative survivors died of cancer 3.2 to 32 months postoperatively, and 12 are alive 3 to 28 months after operation. The actuarial survival is 53 +/- 11% (+/- standard error) at one year and 46 +/- 12% at two years. Transhiatal esophagectomy is a reasonable, safe operation that should be considered for tumors at all levels of the esophagus.


Subject(s)
Adenocarcinoma/surgery , Carcinoma, Squamous Cell/surgery , Esophageal Neoplasms/surgery , Esophagus/surgery , Postoperative Complications/epidemiology , Actuarial Analysis , Adenocarcinoma/mortality , Adult , Aged , Carcinoma, Squamous Cell/mortality , Esophageal Neoplasms/mortality , Female , Follow-Up Studies , Humans , Male , Methods , Middle Aged , Time Factors
10.
Am J Gastroenterol ; 80(7): 526-8, 1985 Jul.
Article in English | MEDLINE | ID: mdl-4014101

ABSTRACT

A case of achalasia associated with squamous cell carcinoma of the esophagus is presented. Microscopic examination of the resected esophagus demonstrated abundant nerve fibers but absent ganglion cells throughout the tumor-involved segment. This finding is believed to be the cause of achalasia in this patient.


Subject(s)
Carcinoma, Squamous Cell/complications , Esophageal Achalasia/etiology , Esophageal Neoplasms/complications , Esophageal Achalasia/pathology , Esophagus/pathology , Humans , Male , Middle Aged , Myenteric Plexus/pathology , Nerve Degeneration
11.
Ann Surg ; 201(5): 618-25, 1985 May.
Article in English | MEDLINE | ID: mdl-3994435

ABSTRACT

Forty-eight consecutive patients with myasthenia gravis (MG) attended by generalized weakness were treated by complete thymectomy, performed transsternally in 46 patients and through a left thoracotomy in two with thymomas. There were no operative deaths. A 12-year-old child with fulminating MG died of acute pneumonia shortly after hospital discharge. Of the remaining 47 evaluable patients, thymectomy resulted in complete remission in six, marked improvement with a reduced need for medication in 20, and mild improvement on the same dosage of medication in 18. Neither the age of the patient, nor the histopathology of the excised thymus, nor the postoperative change in acetylcholine receptor antibody titer were found to have a significant influence on the response to thymectomy. If the ten patients who were 20 years of age or younger were excluded, the patients with a shorter duration of MG achieved a better response to operation. The authors conclude that thymectomy is effective treatment for MG, regardless of the age of the patient or the type of thymic pathology.


Subject(s)
Myasthenia Gravis/surgery , Thymectomy/methods , Adolescent , Adult , Aged , Atrophy/pathology , Female , Follow-Up Studies , Humans , Hyperplasia/pathology , Male , Middle Aged , Myasthenia Gravis/diagnostic imaging , Phrenic Nerve/injuries , Prognosis , Surgical Wound Infection/etiology , Thymectomy/adverse effects , Thymoma/surgery , Thymus Gland/pathology , Thymus Neoplasms/surgery , Tomography, X-Ray Computed
12.
Ann Thorac Surg ; 38(3): 183-7, 1984 Sep.
Article in English | MEDLINE | ID: mdl-6476939

ABSTRACT

Sixty-four consecutive patients with penetrating cardiac injuries were treated between January, 1977, and January, 1983, at the University of Maryland Hospital. Twenty-eight patients had major associated injuries of other organs. The patients were divided into groups according to their clinical status on arrival. An aggressive approach was utilized including early emergency room (ER) thoracotomy for "lifeless" or deteriorating patients. Three patients required immediate cardiopulmonary bypass for repair of their injuries. Twenty-one (57%) of the 37 patients undergoing ER thoracotomy survived; most of the deaths occurred in patients arriving "lifeless" from gunshot wounds. Twenty-four (89%) of the 27 patients who were in stable enough condition to undergo initial repair in the operating room (OR) survived. Overall survival was 45 patients (70%). Though superficial wound infections developed in 18 patients, there were no deep or systemic infections. None of the survivors sustained severe neurological sequelae. Five patients underwent late reoperations for closure of a ventricular septal defect (2), mitral valve replacement (1), and pericardiectomy (2) with no deaths. Though repair of penetrating cardiac injuries should preferably be carried out in the OR, immediate thoracotomy for "lifeless" or deteriorating patients can be performed in the ER with a low incidence of direct surgical complications and with high patient survival.


Subject(s)
Emergency Service, Hospital , Heart Injuries/surgery , Thoracic Surgery , Wounds, Gunshot/surgery , Wounds, Stab/surgery , Adolescent , Adult , Child , Female , Heart Injuries/mortality , Humans , Male , Middle Aged , Postoperative Complications , Wound Infection/etiology , Wounds, Gunshot/mortality , Wounds, Stab/mortality
13.
Ann Thorac Surg ; 37(3): 192-6, 1984 Mar.
Article in English | MEDLINE | ID: mdl-6703802

ABSTRACT

Twenty-four colon interpositions were performed in a group of 23 patients comprising both adults and children between 1965 and early 1982. The indications for operation were caustic injury in 13 patients, peptic stricture in 6, congenital atresia or stenosis in 2, and gunshot or foreign body injury in 2. Long colon segments, consisting of isoperistaltic left colon in seven instances, antiperistaltic left colon in four, and right colon in five, were utilized for 16 procedures in 15 patients. Short segments of left colon were used in 8 patients, isoperistaltic in 6 and antiperistaltic in 2. There were no operative deaths. Ischemic complications necessitated removal of the transplant and replacement with another segment in 1 patient and revision or drainage procedures in 2 others. Strictures of the esophagocolic anastomosis occurred in 6 patients. Five of these strictures occurred among the 13 patients with caustic injury and appeared to be due to unrecognized caustic damage in the esophageal segment used for the anastomosis. Three patients died of unrelated causes eight months to 4 1/2 years after operation, and 3 others were lost to follow-up. Seventeen patients were available for current follow-up 1 to 16 years after operation, including 7 who were followed more than 7 years. When the swallowing ability of these 17 patients was assessed using rigorous criteria, 9 were found to have an excellent to good result; 5, a good to fair result; and 3, a poor result. No patient showed late deterioration of function. We conclude that interposed colon is the ideal esophageal substitute for the patient with benign disease.


Subject(s)
Colon/transplantation , Esophageal Diseases/surgery , Adolescent , Adult , Aged , Child , Colon/pathology , Esophageal Stenosis/etiology , Esophagus/injuries , Esophagus/surgery , Female , Follow-Up Studies , Humans , Male , Methods , Middle Aged , Necrosis/etiology , Postoperative Complications
14.
Ann Thorac Surg ; 36(3): 258-64, 1983 Sep.
Article in English | MEDLINE | ID: mdl-6615063

ABSTRACT

Thirty-one rhesus monkeys were divided into six groups: a control group of 4 monkeys in which resection of 33% of the thoracic esophagus with end-to-end anastomosis was performed without myotomy, and test groups of 4 to 6 monkeys each in which circular myotomy in the proximal segment, distal segment, or both was combined with a 25% or 33% resection. In the control group, 2 of 4 monkeys survived. In the test groups, myotomy reduced longitudinal tension by 20 to 58%. Among the survivors were 4 of 6 animals that had 25% resection with proximal myotomy, 3 of 5 having 25% resection with distal myotomy, and 3 of 4 having 25% resection with combined proximal and distal myotomy. However, 4 of 5 monkeys that had 33% resection plus proximal myotomy and all 5 having 33% resection plus distal myotomy died of anastomotic leaks or strictures. Cineesophagography in surviving monkeys showed no motility disturbance at the myotomy sites. Manometry in 5 monkeys showed no change in resting lower esophageal sphincter pressure from that measured preoperatively. Postmortem examination in long-term survivors showed no stricture or dilatation at the myotomy sites. It is concluded that circular myotomy in the rhesus monkey reduces longitudinal tension, but compromise of the esophageal blood supply limits the usefulness of the procedure in bridging long gaps in the esophagus. Myotomy did not result in any motility disturbance or late anatomical sequelae, and therefore is still a valid procedure to facilitate the repair of short defects.


Subject(s)
Esophagus/surgery , Animals , Constriction, Pathologic/etiology , Esophagus/anatomy & histology , Esophagus/physiology , Macaca mulatta , Macaca nemestrina , Muscle, Smooth/surgery , Postoperative Complications/pathology
15.
Ann Thorac Surg ; 33(5): 464-72, 1982 May.
Article in English | MEDLINE | ID: mdl-6177293

ABSTRACT

Twelve years of experience have now been gained with a new therapeutic approach to carcinoma of the esophagus. In this approach, the primary goal of treatment is palliation, with cure an important but secondary objective. Carcinomas in the upper third of the esophagus are treated by radiation therapy unless there is severe obstruction or tracheal invasion, in which case colon interposition is performed. Limited resection with esophagogastrostomy is performed through a right thoracotomy and midline laparotomy for neoplasms in the middle third of the esophagus and through a left thoracotomy for carcinomas in the lower third. Since 1969, 161 patients have been evaluated, of whom 107 (66%) have been managed according to the new protocol. Twenty patients with carcinomas of the upper third of the esophagus were treated primarily by radiotherapy and 7 by colon interposition. Resection was performed in 78 of the 80 patients with carcinomas of the middle and lower thirds. There were 9 operative deaths (10%). Palliation, of superior quality to that obtained by previous methods, was provided to 95 of the 107 patients. Survival also is at least on a par with that obtained before.


Subject(s)
Carcinoma, Squamous Cell/surgery , Esophageal Neoplasms/surgery , Carcinoma, Squamous Cell/radiotherapy , Esophageal Neoplasms/radiotherapy , Gastrectomy , Gastrostomy , Humans , Methods , Palliative Care , Stomach/surgery
16.
Ann Thorac Surg ; 30(5): 465-71, 1980 Nov.
Article in English | MEDLINE | ID: mdl-7436617

ABSTRACT

Seventeen patients with malignant pericardial effusion were treated by the creation of a pericardial window. This was done through a subxiphoid approach in 13 patients and through limited anterior thoracotomy or sternotomy incisions in 4. There were no deaths and no major complications attributable to the operation. In all patients, relief of the cardiac compression caused by the effusion was immediate and complete. No patient showed a clinically significant recurrence of the effusion, although 1 patient who had received irradiation required pericardiectomy for constriction 5 months later. Survival was determined principally by the extent of the primary malignancy. Six patients died of the primary tumors within 30 days, but 6 survived 3 to 12 months and 2 are alive at 8 and 21 months. It is concluded that creation of a pericardial window, preferably by the subxiphoid approach, is the treatment of choice for malignant pericardial effusion. The procedure provides an accurate diagnosis, carries virtually no mortality or morbidity, and affords immediate and long-lasting relief of cardiac compression.


Subject(s)
Cardiac Surgical Procedures/methods , Pericardial Effusion/surgery , Pericardium/surgery , Suction/methods , Adult , Aged , Female , Follow-Up Studies , Heart Neoplasms/complications , Heart Neoplasms/secondary , Humans , Male , Middle Aged , Pericardial Effusion/etiology , Xiphoid Bone/surgery
18.
Ann Thorac Surg ; 28(3): 224-9, 1979 Sep.
Article in English | MEDLINE | ID: mdl-90489

ABSTRACT

Between 1968 and 1978, 26 patients with carcinomas of the thoracic esophagus and 4 with adenocarcinomas involving the esophagogastric junction were treated by the insertion of indwelling intraluminal (endoesophageal) tubes. Four different types of tube were inserted by the pull-through technique. Thirteen of the 30 patients died in the hospital within 30 days. However, among the 20 patients who did not have neoplasms of the upper third of the thoracic esophagus or who had not had a prior resection, only 5 died. The principal cause of death was aspiration pneumonia. Survival averaged 2.5 months. Four patients survived 5 to 7 months. Deglutition was adequate in most patients but was not as satisfactory as after esophagogastrectomy. Our best results were obtained in patients with carcinoma of the middle or lower third of the esophagus, with or without an esophagorespiratory fistula, who had not had a previous resection.


Subject(s)
Esophageal Neoplasms/surgery , Esophagus , Intubation , Palliative Care , Adenocarcinoma/surgery , Aged , Carcinoma, Squamous Cell/surgery , Female , Humans , Male , Maryland , Methods , Middle Aged , Postoperative Complications/mortality , Prostheses and Implants , Time Factors
19.
Ann Thorac Surg ; 28(2): 126-32, 1979 Aug.
Article in English | MEDLINE | ID: mdl-112930

ABSTRACT

Segments ranging from 40 to 70% of the thoracic esophagus were resected in 80 mongrel dogs. End-to-end anastomosis was effected after circular myotomy either proximal or distal, or both proximal and distal, to the anastomosis. Among dogs undergoing resection of 60% of the esophagus, distal myotomy enabled 6 of 8 animals to survive, and combined proximal and distal myotomy permitted 8 of 10 to survive. Cineesophagography was performed in a majority of the 50 surviving animals and showed no appreciable delay of peristalsis at the myotomy sites. When these sites were examined at postmortem examination up to 13 months after operation, 1 dog showed a small diverticulum but none showed dilatation or stricture. It is concluded that circular myotomy holds real promise as a means of extending the clinical application of esophageal resection with end-to-end anastomosis.


Subject(s)
Esophagus/surgery , Animals , Cineradiography , Diverticulum/etiology , Dogs , Esophagus/diagnostic imaging , Esophagus/physiology , Follow-Up Studies , Methods , Muscle Contraction , Pneumonia/etiology , Postoperative Complications
20.
Am Surg ; 45(3): 168-75, 1979 Mar.
Article in English | MEDLINE | ID: mdl-373533

ABSTRACT

One hundred and thirty-two consecutive patients with lung contusion were admitted during the three-year period of 1972 through 1974. All were treated with early intubation and mechanical ventilation with positive and-expiratory pressure with the postulate that such management would minimize the progression of interstitial edema, and intra-alveolar hemorrhage. If progressive increase in the alveolar/arterial oxygen tension gradient was not observed over the ensuing 24 hours, and in the absence of other non-thoracic indications of continuance of mechanical ventilation, patients were extubated and removed from the ventilator. All other patients were further ventilated and followed by daily chest roentgenograms and blood gas studies. Mean ventilation time was 6.2 days. Progressive hypoxemia and deterioration of pulmonary function were not seen. The incidence of pneumonia and tension pneumothorax was low. Overall mortality was 10.6 per cent. The most common cause of death was brain death. No deaths were the result of hypoxemia.


Subject(s)
Contusions/therapy , Lung Diseases/therapy , Adult , Brain Death , Carbon Dioxide/blood , Contusions/blood , Contusions/diagnostic imaging , Humans , Lung Diseases/blood , Lung Diseases/diagnostic imaging , Oxygen Consumption , Pneumonia/etiology , Pneumothorax/etiology , Positive-Pressure Respiration , Radiography , Respiration, Artificial/adverse effects
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