ABSTRACT
Objective: To map and explore existing evidence on the use of digital technology to deliver healthcare services with explicit consideration of health inequalities in UK settings. Methods: We searched six bibliographic databases, and the National Health Service (NHS) websites of each UK nation (England, Scotland, Wales, Northern Ireland). Restrictions were applied on publication date (2013-2021) and publication language (English). Records were independently screened against eligibility criteria by pairs of reviewers from the team. Articles reporting relevant qualitative and/or quantitative research were included. Data were synthesised narratively. Results: Eleven articles, reporting data from nine interventions, were included. Articles reported findings from quantitative (n = 5), qualitative (n = 5), and mixed-methods (n = 1) studies. Study settings were mainly community based, with only one hospital based. Two interventions targeted service users, and seven interventions targeted healthcare providers. Two studies were explicitly and directly aimed at (and designed for) addressing health inequalities, with the remaining studies addressing them indirectly (e.g. study population can be classed as disadvantaged). Seven articles reported data on implementation outcomes (acceptability, appropriateness, and feasibility) and four articles reported data on effectiveness outcomes, with only one intervention demonstrating cost-effectiveness. Conclusions: It is not yet clear if digital health interventions/services in the UK work for those most at risk of health inequalities. The current evidence base is significantly underdeveloped, and research/intervention efforts have been largely driven by healthcare provider/system needs, rather than those of service users. Digital health interventions can help address health inequalities, but a range of barriers persist, alongside a potential for exacerbation of health inequalities.
ABSTRACT
The greatest physiological threat to terrestrial life is dehydration; however, examining the factors that influence water balance in a teaching setting can be problematic. The proposed exercise examines cutaneous water loss using gelatin frogs. The use of models provides a unique approach to learning about water loss without the need of Institutional Animal Care and Use Committee approval or specialized equipment to measure dehydration from relatively small invertebrates. The first described hands-on experiment examines gelatin frogs of different sizes to understand how surface area-to-volume ratio impacts water loss. The second experiment exposes gelatin models to various conditions, such as convective air currents (wind) or extreme temperature, to understand how abiotic factors influence the vapor pressure deficit between the animal and environment and thus water loss. These easily adaptable activities use everyday household items and can be scaled accordingly to classes of different sizes and academic levels. Thus these flexible exercises can be approached through facilitated, guided, or open inquiry, as students formulate hypotheses, design the experiments, create graphs, and interpret the data through answering questions or a write up.
Subject(s)
Body Temperature Regulation , Water , Animals , Humans , Water-Electrolyte BalanceABSTRACT
CONTEXT: The toxicokinetics of sustained-release bupropion are not well described. CASE: A 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed T(max) was found to be 8.25 h, the calculated alpha half-life 10.9 h (+/-SE of 4.47%), and the calculated beta half-life 19.8 h (+/-SE 12.62%). The alpha half-life and T(max) differ significantly from those seen in therapeutic doses. DISCUSSION: Bezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.
