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3.
Dermatol Surg ; 47(7): 891-907, 2021 07 01.
Article in English | MEDLINE | ID: mdl-34228675

ABSTRACT

SUMMARY: A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide evidence-based recommendations to improve patient care. Given the heterogeneity of reconstructive techniques and clinical scenarios, investigation centered around common elements in the process. In some cases, a distinction was made between treatment options in the office-based setting as opposed to those in the facility setting. A systematic literature review was performed, and an established appraisal process was used to rate the quality of relevant scientific research (Grading of Recommendations Assessment, Development, and Evaluation methodology). Final recommendations are related to concepts concerning the timing of reconstruction, management of anticoagulation, use of antibiotics, methods of pain control, and follow-up assessment. At times, there was insufficient evidence to make high-level recommendations. The literature analysis highlights the need for additional methodologically robust studies in this area, to help guide clinical practice.


Subject(s)
Dermatologic Surgical Procedures/standards , Evidence-Based Medicine , Skin Neoplasms/surgery , Humans , Practice Guidelines as Topic
4.
J Am Acad Dermatol ; 85(2): 423-441, 2021 08.
Article in English | MEDLINE | ID: mdl-33931288

ABSTRACT

A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide evidence-based recommendations to improve patient care. Given the heterogeneity of reconstructive techniques and clinical scenarios, investigation centered around common elements in the process. In some cases, a distinction was made between treatment options in the office-based setting as opposed to those in the facility setting. A systematic literature review was performed, and an established appraisal process was used to rate the quality of relevant scientific research (Grading of Recommendations Assessment, Development, and Evaluation methodology). Final recommendations are related to concepts concerning the timing of reconstruction, management of anticoagulation, use of antibiotics, methods of pain control, and follow-up assessment. At times, there was insufficient evidence to make high-level recommendations. The literature analysis highlights the need for additional methodologically robust studies in this area, to help guide clinical practice.


Subject(s)
Dermatologic Surgical Procedures/standards , Skin Neoplasms/surgery , Evidence-Based Medicine , Humans , Practice Guidelines as Topic
5.
Plast Reconstr Surg ; 147(5): 812e-829e, 2021 May 01.
Article in English | MEDLINE | ID: mdl-33890904

ABSTRACT

SUMMARY: A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide evidence-based recommendations to improve patient care. Given the heterogeneity of reconstructive techniques and clinical scenarios, investigation centered around common elements in the process. In some cases, a distinction was made between treatment options in the office-based setting as opposed to those in the facility setting. A systematic literature review was performed, and an established appraisal process was used to rate the quality of relevant scientific research (Grading of Recommendations Assessment, Development, and Evaluation methodology). Final recommendations are related to concepts concerning the timing of reconstruction, management of anticoagulation, use of antibiotics, methods of pain control, and follow-up assessment. At times, there was insufficient evidence to make high-level recommendations. The literature analysis highlights the need for additional methodologically robust studies in this area, to help guide clinical practice.


Subject(s)
Dermatologic Surgical Procedures , Evidence-Based Medicine , Skin Neoplasms/surgery , Humans , Practice Guidelines as Topic
6.
J. Am. Acad. Dermatol ; 85(2): 423-441, Apr. 27, 2021.
Article in English | BIGG - GRADE guidelines | ID: biblio-1281325

ABSTRACT

A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide evidence-based recommendations to improve patient care. Given the heterogeneity of reconstructive techniques and clinical scenarios, investigation centered around common elements in the process. In some cases, a distinction was made between treatment options in the office-based setting as opposed to those in the facility setting. A systematic literature review was performed, and an established appraisal process was used to rate the quality of relevant scientific research (Grading of Recommendations Assessment, Development, and Evaluation methodology). Final recommendations are related to concepts concerning the timing of reconstruction, management of anticoagulation, use of antibiotics, methods of pain control, and follow-up assessment. At times, there was insufficient evidence to make high-level recommendations. The literature analysis highlights the need for additional methodologically robust studies in this area, to help guide clinical practice.


Subject(s)
Humans , Skin/injuries , Skin Neoplasms/rehabilitation
8.
Am J Sports Med ; 45(10): 2364-2371, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28520458

ABSTRACT

BACKGROUND: The original approach for the repair of torn rotator cuffs involved an open technique with sutures passing through the greater tuberosity and tendon. The development of suture anchors allowed for an all-arthroscopic approach with anchor configurations attempting to re-create a transosseous fixation pattern. Presently, an arthroscopic approach can be combined with a transosseous suture configuration without using anchors. PURPOSE: To evaluate cyclic loading, ultimate load to failure, and the failure mechanisms of transosseous-equivalent (TOE) repair with anchors and anchorless transosseous (AT) repair of rotator cuff tears. STUDY DESIGN: Controlled laboratory study. METHODS: Supraspinatus tears (25 mm) were created in 20 fresh-frozen, human cadaveric shoulders, which were randomized to TOE or AT repair (10 in each group, paired experimental design). Biomechanical testing was performed with an initial preload, cyclic loading, and load to failure. Optical markers were used to monitor gap formation in 3 planes, and the failure mode was recorded. Paired t tests were used to make comparisons of biomechanical parameters between the groups. Multinomial logistic regression was used to compare failure modes between the groups. Significance was set to .05. RESULTS: The TOE group had a significantly higher mean (±SD) ultimate failure load (578.5 ± 123.8 N) than the AT group (468.7 ± 150.9 N) ( P = .034). The TOE group also had a significantly less mean first-cycle excursion (2.97 ± 1.97 mm) than the AT group (4.70 ± 2.04 mm) ( P = .046). There were no significant differences between the groups in cyclic elongation or linear stiffness during cyclic loading. Primary modes of failure were a type 2 tendon tear with medial tendon disruption in the TOE group (7/10) and a type 1 tendon tear with lateral tendon disruption in the AT group (6/10). CONCLUSION: TOE repair resulted in a significantly higher mean failure load compared with AT repair in a cadaveric model. The most common modes of failure were a type 2 tendon tear in the TOE group and a type 1 tendon tear in the AT group. CLINICAL RELEVANCE: A higher mean failure load in TOE versus AT constructs may come at the cost of a less favorable failure mode adjacent to medial anchors at the musculotendinous junction, potentially making revision difficult.


Subject(s)
Arthroplasty/methods , Rotator Cuff Injuries/surgery , Aged , Aged, 80 and over , Arthroplasty/instrumentation , Biomechanical Phenomena , Cadaver , Female , Humans , Male , Rotator Cuff/chemistry , Rotator Cuff/surgery , Suture Anchors , Suture Techniques , Sutures , Tendons/surgery
10.
Plast Reconstr Surg ; 129(3): 572-581, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22373964

ABSTRACT

BACKGROUND: To address those patients who do not meet anatomical criteria for nipple-sparing mastectomy, the authors use a staged approach: (1) mastopexy or breast reduction, (2) nipple-sparing mastectomy through the mastopexy incisions after a minimum of 3 to 4 weeks, and (3) the final reconstruction. METHODS: Fifteen patients underwent nipple-sparing mastectomy at Georgetown University Hospital between 2007 and 2010 after planned or unrelated mastopexy or reduction. An institutional review board-approved retrospective chart review recorded demographic information and outcomes such as skin necrosis and device failure. RESULTS: Fifteen patients (24 breasts) underwent nipple-sparing mastectomy after mastopexy or reduction with an average follow-up of 13 months. The staged procedure was planned in 10 patients [19 breasts (79 percent)] and unplanned, or coincidental, in five [five breasts (21 percent)]. The mastectomy was prophylactic in 17 breasts (71 percent) and therapeutic in seven (29 percent). Four of the 24 operated breasts (17 percent) experienced a complication. Two patients [two breasts (8 percent)] developed skin flap necrosis. Two patients [three breasts (13 percent)] developed minimal partial nipple-areola complex necrosis. One patient [one breast (4 percent)] had an expander explanted for infection related to skin flap necrosis. Fourteen patients [23 breasts (96 percent)] successfully recovered following nipple-sparing mastectomy and prior mastopexy or reduction without residual effects of nipple-areola complex or skin flap necrosis. CONCLUSIONS: The authors are comfortable offering the staged approach to nipple-sparing mastectomy to patients with moderately large or ptotic breasts. It may not be suitable for the very large or ptotic breast. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.


Subject(s)
Breast Neoplasms/surgery , Mammaplasty/methods , Mastectomy/methods , Nipples/surgery , Adult , Aged , Female , Humans , Middle Aged , Retrospective Studies
11.
Plast Reconstr Surg ; 128(5): 1005-1014, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21738086

ABSTRACT

BACKGROUND: Nipple-sparing mastectomy remains controversial and its adoption has been slow because of oncologic and surgical concerns. METHODS: A retrospective study evaluated all nipple-sparing mastectomies performed at a single institution for therapeutic or prophylactic indications for which records were available. RESULTS: Between 1989 and 2010, 162 nipple-sparing mastectomies were performed in 101 women. Forty-nine (30 percent) were performed for therapeutic purposes on 48 patients. A subareolar biopsy specimen was taken in 39 of 49 breasts (80 percent); four (10 percent) revealed ductal carcinoma in situ, and the nipple or nipple-areola complex was later removed. Four of 49 breasts (8 percent) in the therapeutic group had ischemic complications involving the nipple-areola complex, one of which (2 percent) was excised. With a mean follow-up of 2 years 6 months (range, 5 months to 9 years 5 months), no patients developed cancer in the nipple-areola complex. The remaining 113 mastectomies (70 percent) were performed prophylactically on 80 patients. The subareolar tissue was biopsied in 80 breasts (71 percent). One biopsy revealed lobular carcinoma in situ; none had ductal carcinoma in situ or invasive cancer. Two nipple-areola complexes (1.8 percent) were ischemic and excised. With a mean follow-up of 3 years 7 months (range, 5 months to 20 years 6 months), no patients developed new primary cancers in the nipple-areola complex. CONCLUSIONS: Nipple-sparing mastectomy can be safe in properly selected patients. A subareolar biopsy can effectively identify nipple-areola complexes that may harbor cancerous cells. Ischemic complications resulting in nipple loss can be minimized, and long-term follow-up suggests that this technique deserves further investigation in properly selected patients. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.


Subject(s)
Breast Neoplasms/pathology , Breast Neoplasms/surgery , Mastectomy, Subcutaneous/methods , Nipples , Organ Sparing Treatments/methods , Adult , Age Factors , Aged , Biopsy, Needle , Breast Neoplasms/prevention & control , Cohort Studies , Female , Follow-Up Studies , Humans , Immunohistochemistry , Middle Aged , Neoplasm Invasiveness/pathology , Neoplasm Staging , Patient Selection , Retrospective Studies , Risk Assessment , Safety Management , Treatment Outcome
12.
Plast Reconstr Surg ; 127(6): 2167-2175, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21617450

ABSTRACT

BACKGROUND: Oncoplastic reduction mammaplasty offers patients breast conservation with the added benefit of functional improvement in symptoms related to macromastia. The reduction can be performed in the immediate setting with the lumpectomy, in a staged-immediate fashion after final pathology has been confirmed or in a delayed fashion after completion of both lumpectomy and radiation. This study compared quality of life and aesthetic outcomes for these different cohorts. METHODS: A retrospective review was carried out on 16 consecutive patients who had oncoplastic reduction mammaplasty by the senior author (M.Y.N.) between 2003 and 2009. Demographics, oncologic treatment and timing, and reduction techniques were recorded. Patients were asked to complete a questionnaire to assess quality of life and satisfaction. Preoperative and postoperative photographs were evaluated by 15 reviewers. RESULTS: Over a 7-year period, five patients had immediate, six had staged-immediate, and five had delayed reduction mammaplasty. Mean patient age was 52.5 years, and mean body mass index was 31.5. The average timing of reduction was 0, 49, and 734 days for the three groups. Positive margins occurred in two patients, leading to completion mastectomy. In addition, one patient in the staged-immediate group had a recurrence that led to completion mastectomy. Complications occurred in seven (44 percent) of 16 patients. Questionnaire response was 75 percent (12 of 16), showing positive scores in all groups but no statistical significance. Objective aesthetic evaluation also revealed significant improvements within groups comparing various preoperative to postoperative parameters. Importantly, aesthetic scores for the delayed group were consistently lower across all aspects but did not reach significance. CONCLUSION: Oncoplastic reduction mammaplasty can be safe and effective in carefully selected patients in the immediate, staged-immediate, and delayed settings.


Subject(s)
Breast Neoplasms/surgery , Mammaplasty , Mastectomy, Segmental , Quality of Life , Breast Neoplasms/radiotherapy , Esthetics , Female , Humans , Mammaplasty/psychology , Middle Aged , Patient Satisfaction , Surveys and Questionnaires
13.
Plast Reconstr Surg ; 123(6): 1665-1673, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19483564

ABSTRACT

BACKGROUND: The debate over nipple-sparing mastectomy continues to evolve. Over the past several years, it has become more widely accepted, especially in the setting of prophylactic mastectomy, but its role in the treatment of breast cancer has only recently been reexamined. METHODS: Two indications for the procedure are discussed: prophylactic, for the high-risk patient; and the more controversial topic, therapeutic nipple-sparing mastectomy, for the patient with breast cancer. A review of the literature suggests that certain breast cancers may be amenable to retaining the nipple if they meet specific oncologic criteria: tumor size 3 cm or less, at least 2 cm from the nipple, not multicentric, and with clinically negative nodes. Moreover, newer technologies such as magnetic resonance imaging and preoperative mammotome biopsy may make the procedure even safer in this setting. Practical and technical aspects of the procedure are discussed, including patient selection. RESULTS: The accumulating data from multiple series of nipple-sparing mastectomy show that properly screened patients have a low risk of local cancer recurrence, that recurrences occur rarely in the nipple, and that recurrences in the nipple can be managed by removing the nipple. CONCLUSIONS: Despite continued controversy and the need for more long-term outcome data, nipple-sparing mastectomy is a procedure that is gaining increasing visibility and acceptance. Provided that certain oncologic and practical criteria are applied, it has the potential for allowing less invasive surgery and improved cosmetic outcomes without increased oncologic risk in appropriately selected patients.


Subject(s)
Breast Neoplasms/surgery , Carcinoma, Intraductal, Noninfiltrating/surgery , Mastectomy , Nipples , Salvage Therapy , Adult , Female , Humans , Middle Aged , Neoplasm Recurrence, Local/prevention & control
14.
Semin Plast Surg ; 23(2): 132-40, 2009 May.
Article in English | MEDLINE | ID: mdl-20567735

ABSTRACT

Although osteomyelitis is a difficult problem, certain conditions make it even more difficult to address. Diabetes, peripheral vascular disease, and radiation are all comorbidities that interfere with wound healing and therefore make the treatment of osteomyelitis challenging. In this article, we discuss these conditions, their pathophysiology, and highlight the special considerations in treating osteomyelitis in patients with these comorbidities.

15.
Plast Reconstr Surg ; 120(7): 1843-1858, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18090746

ABSTRACT

BACKGROUND: The accepted standard for treatment of human immunodeficiency virus disease, highly active antiviral therapy, may cause significant side effects, such as facial lipoatrophy and lipodystrophy. Facial wasting or a buffalo hump deformity may be pathognomonic for treated human immunodeficiency virus disease. In addition to facial wasting, cystic parotid degeneration may further distort the face. The authors outline the defects as a series of triangles defined by anatomical boundaries. METHODS: In a group of 27 patients, 17 were treated for buffalo hump (three isolated and 14 with associated facial wasting). Another 10 patients were treated for isolated facial wasting. RESULTS: The 14 patients who underwent liposuction of the buffalo hump with subsequent injection of the aspirate into the face had approximately 40 to 50 percent of the grafts survive. Recurrent or severely fibrous humps were treated with ultrasound-assisted liposuction. In six patients, autografts to the lypoatrophic face were utilized. Two patients undergoing gynecomastia reduction had successful grafting with the resected breast. Three patients with cystic degeneration of the parotid underwent superficial parotidectomy with rotation or grafting of the parotid into the defect, for a total of six individual procedures. CONCLUSION: The authors present an algorithm for treatment of buffalo hump and facial wasting deformities associated with human immunodeficiency virus lipodystrophy syndrome, with an emphasis on long-term results with autogenous tissue.


Subject(s)
Face/surgery , HIV-Associated Lipodystrophy Syndrome/surgery , Surgery, Plastic/methods , Adipose Tissue/transplantation , Adult , Algorithms , Back/surgery , Cellulose/therapeutic use , Disease Progression , Gynecomastia/surgery , HIV-Associated Lipodystrophy Syndrome/pathology , Humans , Lactic Acid/therapeutic use , Lipectomy/methods , Male , Mannitol/therapeutic use , Necrosis , Parotid Gland/transplantation , Patient Satisfaction , Polymers/therapeutic use , Retrospective Studies , Surgical Flaps/pathology , Transplantation, Autologous , Transplantation, Heterotopic
16.
Plast Reconstr Surg ; 116(7): 1873-80, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16327598

ABSTRACT

BACKGROUND: The detrimental effects of smoking on pedicled and free flap reconstruction are well documented. The purpose of this study was to examine the effect of smoking on flap, donor-site, and other individual and multiple complications in pedicled transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction. METHODS: A retrospective review was carried out of 224 pedicled TRAM flaps in 200 patients over a 10-year period. Three subgroups of patients were identified: active smokers, former smokers (defined as patients who stopped smoking at least 4 weeks before reconstruction), and nonsmokers (patients with no history of smoking). Active smokers made up 15.5 percent of the study population, while former smokers and nonsmokers made up 17.5 percent and 67 percent, respectively. There were no statistically significant differences in age, weight, radiation/chemotherapy history, distribution of flap pedicle types, timing of reconstruction, or percentage of delay procedures performed among the smoking subgroups. Logistic regression analysis was used to identify significant risk factors and determine their odds ratios. RESULTS: Compared with nonsmokers, both active and former smokers had a higher incidence of multiple flap complications (p = 0.0023 and 0.0018, respectively; odds ratios, 5.1 and 4.9). Active smokers also had a statistically significant higher rate of TRAM infection compared with nonsmokers (p = 0.0243; odds ratio, 4.7). Finally, former smokers were found to have a higher rate of TRAM delayed wound healing compared with nonsmokers (p = 0.0165; odds ratio, 4.7). CONCLUSIONS: Logistic regression identified active smoking as a statistically significant risk factor for developing multiple flap complications and TRAM infection, while former smoking was a risk factor for multiple flap complications and TRAM delayed wound healing. Thus, active and former smoking should similarly be considered contraindications for pedicled TRAM flap breast reconstruction, unless the patient has stopped smoking for more than 4 weeks before surgery.


Subject(s)
Mammaplasty , Postoperative Complications/epidemiology , Smoking/adverse effects , Surgical Flaps , Body Mass Index , Contraindications , Humans , Logistic Models , Odds Ratio , Retrospective Studies , Risk Factors , Seroma/epidemiology , Surgical Flaps/blood supply , Surgical Wound Infection/epidemiology , Tissue and Organ Harvesting
17.
Ann Plast Surg ; 55(6): 559-64, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16327450

ABSTRACT

BACKGROUND: The purpose of this study is to examine the effect of various risk factors on complications in patients undergoing pedicled transverse rectus abdominis musculocutaneous (TRAM) flap breast reconstruction. METHODS: A retrospective review of 224 pedicled TRAMs in 200 patients over a 10-year period was carried out. Patients were divided into subgroups based on smoking history, weight, radiation status, and pedicle type. Complication rates were calculated and logistic regression analysis was used to identify risk factors. RESULTS: Logistic regression identified active smoking as a statistically significant risk factor for developing multiple (2 or more) flap complications (P = 0.0061) and TRAM infection (P = 0.0255), while former smoking was a risk factor for multiple flap complications (P = 0.01) and TRAM-delayed wound healing (P = 0.0433). Obesity (body mass index > or =30) was found to be a statistically significant risk factor for overall (1 or more) donor-site complications (P = 0.0281), overall flap complications (P = 0.0375), multiple flap complications (P = 0.0002), TRAM-delayed wound healing (P = 0.0334), and minor flap necrosis (P = 0.0075). CONCLUSIONS: This study identified that active or former smoking and obesity contribute to a significant complication rate, while overweight body habitus, use of double-pedicled flaps, and pre-TRAM radiation do not. This second decade "look-back" on pedicled TRAM flap breast reconstruction emphasizes the need for appropriate patient selection to achieve successful results with pedicled TRAM breast reconstruction.


Subject(s)
Mammaplasty , Surgical Flaps , Female , Humans , Logistic Models , Middle Aged , Multivariate Analysis , Retrospective Studies , Risk Factors , Smoking/adverse effects , Smoking/epidemiology , Treatment Outcome
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