ABSTRACT
Thirty-five patients with painful bone metastases arising from a variety of tumor types underwent a clinical trial in which 153Sm-EDTMP was injected as a single intravenous dose. The injection ranged in amount from 330 MBq to 1110 MBq of 153Sm-EDTMP. Pain relief usually occurred within one week after administration. The duration of pain relief lasted from 2 to 17 weeks. A detectable degree of pain palliation was experienced by 80% of the treated patients; 54% reported substantial or complete pain relief. Due to the small number of patients, no clear-cut dose-related response was detectable. Moderate myelosuppression was observed in one patient (WHO grade III). The metastatic lesion-to-normal bone ratios remained constant (varying from 1.5 to 4.8) for at least 5 days post-injection. 153Sm cleared very rapidly from the blood. Less than 1% of the injected dose remained in circulation at 4 hours post-injection. No local accumulation of the tracer could be detected outside the skeleton. Urinary excretion was quite complete at 6 hours post-injection. The biodistributions of 153Sm-EDTMP and 99mTc-DPD are very similar in metastatic and normal bone; thus, bone scanning can be used for patient selection and followup. According to our results, it seems that higher doses of 153Sm-EDTMP can be given safely and without any irreversible myelosuppression.
Subject(s)
Bone Neoplasms/radiotherapy , Bone Neoplasms/secondary , Organometallic Compounds/therapeutic use , Organophosphorus Compounds/therapeutic use , Palliative Care/methods , Radioisotopes/therapeutic use , Samarium/therapeutic use , Bone Neoplasms/diagnostic imaging , Breast Neoplasms/pathology , Diphosphonates , Female , Humans , Male , Middle Aged , Organotechnetium Compounds , Prostatic Neoplasms/pathology , Radionuclide ImagingABSTRACT
The effect of deliberate hypotension induced by labetalol on renal function, was studied in 25 patients undergoing middle-ear surgery. The patients were randomized into three groups, one enflurane (E) group and two isoflurane (I and F) groups. Group F received frusemide 0.5 mg kg-1 at the onset of hypotension. The mean arterial pressure was 50 mmHg (6.7 kPa) in Groups E and I, and 49 mmHg (6.5 kPa) in Group F during hypotension. During hypotension, urine flow rate, effective renal blood flow, endogenous creatinine clearance, and osmolar clearance decreased. Free-water clearance and fractional electrolyte excretions also indicated deterioration of renal function during hypotension, but it returned to normal after anaesthesia. The effects of frusemide appeared mainly after anaesthesia. Frusemide reduced the amount of labetalol and isoflurane needed to maintain hypotension. Serum fluoride concentration did not increase to a potentially nephrotoxic level.
Subject(s)
Anesthesia, Inhalation , Enflurane/pharmacology , Furosemide/pharmacology , Hypotension, Controlled , Isoflurane/pharmacology , Kidney/drug effects , Labetalol/therapeutic use , Acid-Base Equilibrium , Adult , Blood Pressure/drug effects , Body Water/drug effects , Body Water/metabolism , Creatinine/urine , Female , Fluorides/blood , Humans , Kidney/physiology , Labetalol/pharmacology , Male , Middle Aged , Oxygen/blood , Renal Circulation/drug effects , Sodium/urine , Urine/physiologyABSTRACT
A single dose of 2 g tinidazole was given preoperatively to 70 patients undergoing elective hysterectomy; 76 patients served as controls. One patient in the drug therapy group and 10 in the control group had a temperature of 38 degrees C at some time after the first postoperative day. One patient in the tinidazole group and seven among the controls had abscess formation. The differences between the tinidazole and the control groups were highly significant. This simple prophylactic procedure reduced treatment costs and minimised infection following hysterectomy.
Subject(s)
Bacterial Infections/prevention & control , Hysterectomy , Nitroimidazoles/therapeutic use , Postoperative Complications/prevention & control , Tinidazole/therapeutic use , Adult , Drug Administration Schedule , Female , Humans , Middle Aged , Tinidazole/administration & dosageABSTRACT
The cervical blood flow changes during labour in pregnant women (15 cases) have been studied by local injection of 133Xe into the cervix. The blood flow changes were compared with the external uterine pressure which was measured with a tocograph. During contractions the radioactivity decreased temporarily, but increased again between contractions. The overall decrease was greater in the control group (4 cases) than during spontaneous contractions. The conclusion is, that relative cervical blood circulation is rapidly changed during labour.
