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1.
J Perinatol ; 41(8): 1963-1971, 2021 08.
Article in English | MEDLINE | ID: mdl-33795789

ABSTRACT

OBJECTIVE: To determine if multidisciplinary team-based care of severe BPD/CLD infants improve survival to discharge. DESIGN/METHODS: Retrospective review of severe BPD/CLD infants cared for by dedicated multidisciplinary CLD team using consensus-driven protocols and guidelines. RESULTS: Total of 267 patients. Median gestational age was 26 weeks (IQR 24, 32); median birth-weight was 0.85 (IQR 0.64, 1.5). Twenty-four percent were preterm with severe BPD, 46% had other primary respiratory diseases (none BPD diseases). Total number of patients, proportion of patients with tracheostomy, prematurity, and genetic diagnoses increased over time. 88.8% survived to discharge. Unadjusted logistic regression showed that tracheostomy was not associated with odds of death; secondary pulmonary hypertension was associated with odds of tracheostomy (OR = 1.795 p value = 0.0264), or death (OR = 8.587 p value = <0.0001), or tracheostomy + death (OR = 13.58 p value = 0.0007). CONCLUSIONS: Over time, mortality improved for infants with tracheostomy cared for by a multidisciplinary severe BPD/CLD team. Secondary pulmonary hypertension was associated with tracheostomy, or death, or tracheostomy + death.


Subject(s)
Bronchopulmonary Dysplasia , Lung Diseases , Bronchopulmonary Dysplasia/epidemiology , Bronchopulmonary Dysplasia/therapy , Chronic Disease , Humans , Infant , Infant, Newborn , Intensive Care Units, Neonatal , Lung Diseases/therapy , Patient Discharge , Retrospective Studies , Tracheostomy
2.
J Perinatol ; 41(4): 891-897, 2021 04.
Article in English | MEDLINE | ID: mdl-33093625

ABSTRACT

OBJECTIVE: Achieve over 90% adherence to consensus guidelines on use of postnatal steroids (PNS) in preterm infants for bronchopulmonary dysplasia (BPD) within 6 months. METHODS: A multidisciplinary team formulated and implemented consensus guidelines using the Plan-Do-Study-Act method of quality improvement. Outcome measure was rate of compliance to guidelines, process measure was age of starting PNS treatment, and balancing measure was rate of repeat steroid courses. RESULTS: Retrospective application of guidelines to preceding 10 months showed mean baseline compliance rate of 71% (n = 42). After implementation, compliance escalated to a mean rate of 96% within 6 months. Rate of PNS treatment ≤ 30 days of life increased from 50 to 80%, while rate of repeat PNS was unchanged. CONCLUSIONS: Compliance with new guidelines for PNS treatment of BPD was quickly attained using simple quality improvement interventions. Further study is needed to evaluate effects of these guidelines on clinical outcomes.


Subject(s)
Bronchopulmonary Dysplasia , Administration, Inhalation , Bronchopulmonary Dysplasia/drug therapy , Glucocorticoids/therapeutic use , Humans , Infant , Infant, Newborn , Infant, Premature , Quality Improvement , Retrospective Studies , Steroids/therapeutic use
3.
J Perinatol ; 38(5): 537-542, 2018 05.
Article in English | MEDLINE | ID: mdl-29453434

ABSTRACT

OBJECTIVE: The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP). STUDY DESIGN: Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups. Secondary outcomes included discharge with home oxygen and severe ROP. RESULT: A total of 100 infants that underwent PDA ligation during the study period were included in the study; 31 (31%) neonates developed PLCS. In adjusted analysis, PLCS was associated with increased risk for severe BPD (RR 1.67, 95% CI: 1.15-2.42) and home oxygen therapy (RR: 1.47, 95% CI: 1.09-1.99) only. No association with severe ROP was seen (RR: 1.48; 95% CI: 0.87-2.52). CONCLUSION: PLCS is associated with severe neonatal pulmonary morbidity, but not with severe ROP. Further investigation is warranted to validate these results.


Subject(s)
Cardiac Surgical Procedures/adverse effects , Ductus Arteriosus, Patent/surgery , Perioperative Care/methods , Postoperative Complications/diagnosis , Female , Humans , Infant, Newborn , Infant, Premature , Ligation/adverse effects , Logistic Models , Male , Morbidity , Postoperative Complications/therapy , Retrospective Studies , Syndrome
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