ABSTRACT
The purpose of this study was to describe the pattern of bacterial infections in children with acute lymphoblastic leukemia. Forty-six children with ALL were treated for 119 febrile episodes. Antibiotic therapy was initiated with ampicillin and gentamicin, +/- dicloxacillin and lasted for 5-8 days. Bacterial cultures were positive in 36 of 119 febrile events. At the beginning of the febrile disease there was no difference in CRP and neutrophil count between children with positive and negative blood cultures. The maximum CRP was, however, significantly higher in children with positive blood cultures. In 75% there was no need to change the initial antibiotic treatment with ampicillin and gentamicin +/- dicloxacillin. If the temperature has been normal for 2-3 days and the neutrophil count is increasing it appears safe to discontinue the antibiotic therapy after five days when blood cultures are negative and after 7-8 days when cultures are positive.
Subject(s)
Bacterial Infections/drug therapy , Opportunistic Infections/microbiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/microbiology , Anti-Bacterial Agents/administration & dosage , Bacterial Infections/etiology , Bacterial Infections/immunology , C-Reactive Protein/analysis , Child , Child, Preschool , Female , Humans , Infant , Leukocyte Count , Male , Neutrophils/immunology , Opportunistic Infections/drug therapy , Opportunistic Infections/immunology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunologyABSTRACT
We describe a boy with a terminal deletion of the long arm of chromosome 18 and chronic arthritis involving both knees, one ankle and the temporomandibular joints. In contrast to the majority of patients with 18q- syndrome he has only slight mental disability. His serum IgA is normal.
Subject(s)
Arthritis/genetics , Chromosome Deletion , Chromosomes, Human, Pair 18 , Abnormalities, Multiple/genetics , Adolescent , Arthritis/complications , Arthritis/diagnosis , Chronic Disease , Humans , Intellectual Disability/complications , Intellectual Disability/diagnosis , Intellectual Disability/genetics , MaleABSTRACT
The aim of the study was to estimate the incidence of Kawasaki's disease and to describe the clinical manifestations and the prognosis of the disease in children in Denmark during the period 1981-1990. In a register of all hospital admissions in Denmark, 99 patients were registered as having Kawasaki's disease. Of those, 89 patients fulfilled the clinical diagnostic criteria. The mean incidence of the ten year period was 1.0 per 100,000 children per year. The incidence of the disease decreased in the age group from zero to seven years after which it was rarely observed. Typical laboratory findings were hypersedimentation, leucocytosis and thrombocytosis. Eight children had cardiomegaly and three had electrocardiographic changes. Echocardiography was performed in 66 patients showing coronary artery aneurysms in nine patients (14%) (six boys and three girls). No further cardiac complications were found.
Subject(s)
Mucocutaneous Lymph Node Syndrome/epidemiology , Adolescent , Child , Child, Preschool , Denmark/epidemiology , Female , Humans , Incidence , Infant , Male , Mucocutaneous Lymph Node Syndrome/diagnosis , Prognosis , Retrospective StudiesABSTRACT
Silver-Russell's syndrome is a condition characterized by pre- and postnatal growth retardation, a triangular face, clinodactyly of the 5th finger, café au lait patches and hemihypertrophy. The majority of patients have normal psychomotor development. A case of Silver-Russell's syndrome complicated by perinatal asphyxia is presented.
Subject(s)
Abnormalities, Multiple , Face/abnormalities , Growth Disorders/congenital , Asphyxia Neonatorum/complications , Child , Female , Fingers/abnormalities , Humans , Infant, Newborn , Ovary/abnormalities , Psychomotor Disorders/etiology , Psychomotor Disorders/physiopathology , SyndromeABSTRACT
In order to evaluate the demand of blood glucose measurements (BG) in the neonatal period, a retrospective study of BG in 177 newborn babies was undertaken. Babies with birth weight less than 2,500 grams, gestational age (GA) less than 37 weeks, and/or a low birth weight in relation til gestational age were included in the study. Accordingly, the babies were grouped as appropriate for GA (AGA), small for gestational age (SGA), or large for GA (LGA). Neonatal hypoglycemia (NH), BG less than or equal to 1.4 mmol/l, was found in 33 babies. In 31 babies, NH occurred before 12 hours of age while six babies had recurrent NH. Correlation was seen between total number of clinical symptoms and NH, which was, as anticipated, commonest among preterm SGA-babies. The risk of subsequent NH in early fed low birth weight newborn seems to be very low, if NH has not appeared within the first 12 hours of life. After this time, serial blood glucose measurements only seem justified, if concomitant perinatal disease is present.
